1.Bilateral Serous Retinal Detachment as a Presenting Sign of Acute Lymphoblastic Leukemia.
Jinseon KIM ; Woohyok CHANG ; Min SAGONG
Korean Journal of Ophthalmology 2010;24(4):245-248
We present a case of bilateral serous retinal detachment (SRD) as a presenting sign of Philadelphia chromosome-positive acute lymphoblastic leukemia (Ph+ ALL). A 45-year-old woman presented with decreased vision and was found to have bilateral serous retinal detachment. Peripheral blood smears revealed leukocytosis of 53.9x10(3)/microliter with 64.6% lymphoblasts. A bone marrow aspirate revealed the presence of lymphoblasts. Cytogenetic and molecular genetic analysis detected a reciprocal translocation between chromosome 9 and 22, t(9;22) (q34;q11). A diagnosis of Ph+ ALL was made. Following systemic chemotherapy, the bilateral SRD resolved completely with full recovery of vision. The sudden appearance of SRD should raise suspicion for leukemia. Prompt recognition of this disease is important for early systemic treatment and restoration of visual function.
Antineoplastic Agents/therapeutic use
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Female
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Fluorescein Angiography
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Follow-Up Studies
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Fundus Oculi
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Humans
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Middle Aged
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Precursor Cell Lymphoblastic Leukemia-Lymphoma/*complications/diagnosis/drug therapy
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Recovery of Function
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Retinal Detachment/diagnosis/*etiology/physiopathology
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Tomography, Optical Coherence
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Visual Acuity/physiology
2.Treatment of Serous Retinal Detachment Associated with Choroidal Ischemia with Intravitreal Bevacizumab Following Brain Surgery.
Young Joo CHO ; Eun Young CHOI ; Hyoung Jun KOH ; Sung Chul LEE ; Min KIM
Korean Journal of Ophthalmology 2014;28(5):424-426
No abstract available.
Angiogenesis Inhibitors/*therapeutic use
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Bevacizumab/*therapeutic use
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Choroid/*blood supply
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Ciliary Arteries/pathology
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Fluorescein Angiography
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Humans
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Intravitreal Injections
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Ischemia/*drug therapy/etiology/physiopathology
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Male
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Meningeal Neoplasms/surgery
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Meningioma/surgery
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Neurosurgical Procedures/*adverse effects
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Retinal Detachment/*drug therapy/etiology/physiopathology
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Subretinal Fluid
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Vascular Endothelial Growth Factor A/antagonists & inhibitors
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Visual Acuity/physiology
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Young Adult