No abstract available.
Bronchiolitis* ; Respiratory Syncytial Viruses*

No abstract available.
Bronchiolitis ; Respiratory Syncytial Viruses

Asthma* ; Respiratory Syncytial Viruses*

No abstract available.
Respiratory Syncytial Virus Infections* ; Respiratory Syncytial Viruses*

No abstract available.
Child* ; Humans ; Respiratory Syncytial Viruses* ; Ribavirin*

No abstract available.
Polymerase Chain Reaction* ; Respiratory Syncytial Viruses

No abstract available.
Bronchiolitis ; Epidemiology ; Pneumonia ; Respiratory Syncytial Viruses

No abstract available.
Respiratory Syncytial Viruses* ; Respiratory System* ; Respiratory Tract Infections*

The dynamics of the virus-host interface in the response to respiratory virus infection is not well-understood; however, it is at this juncture that host immunity to infection evolves. Respiratory viruses have been shown to modulate the host response to gain a replication advantage through a variety of mechanisms. Viruses are parasites and must co-opt host genes for replication, and must interface with host cellular machinery to achieve an optimal balance between viral and cellular gene expression. Host cells have numerous strategies to resist infection, replication and virus spread, and only recently are we beginning to understand the network and pathways affected. The following is a short review article covering some of the studies associated with the Tripp laboratory that have addressed how respiratory syncytial virus (RSV) operates at the virus-host interface to affects immune outcome and disease pathogenesis.
Gene Expression ; Imidazoles ; Nitro Compounds ; Parasites ; Respiratory Syncytial Viruses* ; Viruses

BACKGROUND: Respiratory syncytial virus (RSV) is one of the most important causes of lower respiratory tract infection. The rapid antigen test is a simple, cheap, and quick method for RSV detection, however, it has an acknowledged low sensitivity. The aim of this study is to evaluate the diagnostic performance of the rapid antigen test by comparing it with a multiplex reverse transcription-PCR (RT-PCR). METHODS: A total of 557 nasopharyngeal aspirates or swabs that were submitted for both a rapid antigen test, Binax NOW RSV (Binax; Alere Scarborough, Inc., USA) and multiplex RT-PCR, Seeplex RV7 (Seegene Inc., Korea) were included in this study. We performed both tests according to the manufacturer's recommendations and analyzed the diagnostic performances of a rapid antigen tests based on the results of multiplex RT-PCR. RESULTS: Among the 557 specimens, the positive rates determined from the rapid antigen test and multiplex RT-PCR were 12.2% (N=68) and 25.1% (N=140), respectively. The relative sensitivity and specificity of the rapid antigen test were 46.4% and 99.3% based on the multiplex RT-PCR, respectively. Positive and negative predictive values were 95.6% and 84.7%, respectively. The diagnostic sensitivity was lower (28.6%) in children >36 months compared with children < or =36 months of age. Test sensitivity declined when RSV infection was accompanied by infection with other respiratory viruses. CONCLUSIONS: Binax NOW RSV exhibited good diagnostic performance, easy handling, and rapidity. However, it does have the possibility of false-negative results, and additional tests are needed when there is clinical suspicion of RSV infection.
Child ; Humans ; Respiratory Syncytial Viruses* ; Respiratory Tract Infections ; Sensitivity and Specificity