1.Clinical studies on asthma and wheezing disorders in Chinese children.
Chinese Journal of Pediatrics 2005;43(6):402-405
Anti-Asthmatic Agents
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therapeutic use
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Asthma
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physiopathology
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prevention & control
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therapy
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virology
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Child
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China
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Chronic Disease
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Cough
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physiopathology
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virology
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Drug Therapy, Combination
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Humans
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Respiratory Sounds
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drug effects
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physiopathology
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Respiratory Syncytial Virus Infections
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complications
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physiopathology
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prevention & control
2.Outcomes of Palivizumab Prophylaxis for Respiratory Syncytial Virus Infection in Preterm Children with Bronchopulmonary Dysplasia at a Single Hospital in Korea from 2005 to 2009.
Seung Gu CHANG ; Moon Sung PARK ; Jae Eun YU
Journal of Korean Medical Science 2010;25(2):251-256
This study was performed to evaluate the utilization and outcomes of palivizumab in high risk children born prematurely with chronic lung disease (CLD). A retrospective review of 128 patients was conducted from September 2004 to March 2009 at the Ajou University Hospital. All patients were diagnosed with CLD, were born at < or =35 weeks of gestation, were <2 yr old at the onset of respiratory syncytial virus (RSV) season, and had received medical therapy within six months prior to the RSV season. Fifty-three patients did not receive palivizumab prophylaxis and 75 patients received at least one dose of palivizumab. There were no statistically significant differences between the patients with and without palivizumab prophylaxis with regard to demographic characteristics and risk factors for RSV infection. There were no systemic adverse responses. Compliance with the course of prophylaxis was 92.2%. Hospitalization associated with RSV occurred in 12 cases (22.6%) in the group without prophylaxis and in three cases (4.0%) with prophylaxis. Palivizumab prophylaxis significantly reduced the frequency of RSV-related hospitalization in preterm children with CLD. This is the first retrospective review of palivizumab prophylaxis in Korea. Palivizumab is effective and well tolerated in high risk prematurely born children.
Antibodies, Monoclonal/*therapeutic use
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Antibodies, Monoclonal, Humanized
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Antiviral Agents/*therapeutic use
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Bronchopulmonary Dysplasia/*complications/diagnosis
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Demography
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Hospitalization
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Humans
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Infant
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Infant, Newborn
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Premature Birth
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Republic of Korea
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Respiratory Syncytial Virus Infections/complications/*prevention & control
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Retrospective Studies
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Risk Factors
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Treatment Outcome
3.Effect of Prophylactic Palivizumab on Admission Due to Respiratory Syncytial Virus Infection in Former Very Low Birth Weight Infants with Bronchopulmonary Dysplasia.
Young Mi HAN ; Hyun Joo SEO ; Seo Heui CHOI ; Yu Jin JUNG ; So Yoon AHN ; Hye Soo YOO ; Se In SUNG ; Jae Won SHIM ; Yeon Kyung LEE ; Sun Young KO ; Son Moon SHIN ; Jong Hee HWANG ; Jang Hoon LEE ; Byung Min CHOI ; Eun Sun KIM ; Ji Hyun JEON ; Sung Shin KIM ; Yun Sil CHANG ; Won Soon PARK
Journal of Korean Medical Science 2015;30(7):924-931
The aim of this study was to observe the effects of prophylactic palivizumab on hospitalization secondary to respiratory syncytial virus (RSV) infection (RSVhospitalization) in former very low birth weight infants (VLBWI) with bronchopulmonary dysplasia (BPD). This study also sought to identify the risk factors of RSVhospitalizationin this particular infant population. A prospective observational study was conducted between September 2007 and April 2008 in seven Korean hospitals. Children with a history of very low birth weight, a diagnosis of BPD and who were <2 yr old at the onset of the RSV season were included in this study. Palivizumab injections were administered monthly for a maximum of five months during the RSV season. RSVhospitalization rates were reviewed, and RSVhospitalization rates between subgroups were categorized by gestational age, birth weight, and duration of ventilator care. A total of 90 subjects completed the follow-up interviews. The mean gestational age at birth was 26.1+/-1.7 weeks, and the mean birth weight was 889.4+/-222.2 g. The incidence of RSVhospitalization in the study population was 8.9% (8/90), and the mean hospital stay was 11.0+/-5.5 days, including one death. There were no statistically significant differences in the patients' demographic characteristics or risk factors for RSV hospitalization. When subgroup analyses were conducted, there were still no statistically significant differences. The administration of palivizumab prophylaxis during the entire RSV season is important in VLBWI with BPD, regardless of their gestational age and birth weight, or previous ventilator dependency.
Antibiotic Prophylaxis/*methods
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Antiviral Agents/*therapeutic use
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Birth Weight
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Bronchopulmonary Dysplasia/*complications
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Female
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Gestational Age
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Hospitalization/statistics & numerical data
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Humans
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Infant
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Infant, Newborn
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Infant, Premature
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*Infant, Very Low Birth Weight
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Length of Stay
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Male
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Palivizumab/*therapeutic use
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Prospective Studies
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Respiratory Syncytial Virus Infections/drug therapy/*epidemiology/prevention & control
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Respiratory Syncytial Viruses/drug effects
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Risk
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Risk Factors