AIMTo observe the metabolic interaction between diphenytriazol and steroid hormone drugs, and provide some useful information for clinical medication.

METHODSThe steroid hormone drugs which may be co-administrated with diphenytriazol were selected, such as mifepriston, estradiol, medroxyprogesterone acetate, progesterone, norethisterone and so on. Diphenytriazol was incubated with each drug in rat liver microsome. The residual concentration of diphenytriazol or steroid hormone drugs in the microsomal incubates was determined by reversed-phase high-performance liquid chromatography, separately. The inhibition constants (K(i)) for each of them were calculated.

RESULTSThe inhibition constant K(is) of diphenytriazol for the metabolism of mifepristone, estradiol, medroxyprogesterone acetate, progesterone and norethisterone were (201.3 +/- 1.0), (94 +/- 4), (128.7 +/- 2.2), (64 +/- 5) and (80 +/- 4) micromol x L(-1), respectively. The inhibition constants K(i) of steroid hormone drugs for the metabolism of diphenytriazol was (66.9 +/- 2.2) micromol x L(-1) for estradiol, (60.0 +/- 2.3) micromol x L(-1) for medroxyprogesterone acetate, (163 +/- 10) micromol x L(-1) for progesterone and (88 +/- 5) micromol x L(-1) for norethisterone, respectively.

CONCLUSIONDiphenytriazol shows metabolism interaction with steroid hormone drugs such as estradiol, medroxyprogesterone acetate, progesterone and norethisterone.

Abortifacient Agents, Nonsteroidal ; metabolism ; pharmacology ; Abortifacient Agents, Steroidal ; metabolism ; Animals ; Contraceptives, Oral, Synthetic ; metabolism ; Drug Interactions ; Estradiol ; metabolism ; Female ; In Vitro Techniques ; Medroxyprogesterone ; metabolism ; Microsomes, Liver ; metabolism ; Mifepristone ; metabolism ; Rats ; Rats, Sprague-Dawley ; Triazoles ; metabolism ; pharmacology

OBJECTIVETo evaluate the clinical effect and safety of combined use of methotrexate and mifepristone for treatment of ectopic pregnancy.

METHODSBy searching in the major databases of CNKI, CBMdisk and Pubmed according to the criteria of evidence-based medicine, we collected data of randomized controlled trials pertaining to combined use of methotrexate and mifepristone in the treatment of ectopic pregnancy.

RESULTSTwenty-three randomized controlled trials involving totally 1 706 patients were collected according to the inclusion criteria, and meta-analysis of the data indicated that combined use of methotrexate and mifepristone can be of great value in the management of ectopic pregnancy in comparison with exclusive use of methotrexate [ combined odds ratio (OR) was 2.84 with 95%confidence interval [CI] (2.18, 3.69), Z=7.79, P<0.000 01].

CONCLUSIONThe clinical evidence derived from the analysis suggests that the combination of methotrexate and mifepristone for ectopic pregnancy management can be effective with good safety security and minimal side effects, but still, this conclusion needs further verification by randomized, double-blind, and controlled trials with larger sample size and more rigorous trial design.

Abortifacient Agents, Nonsteroidal ; administration & dosage ; Abortifacient Agents, Steroidal ; administration & dosage ; Adult ; Drug Therapy, Combination ; Female ; Humans ; Methotrexate ; administration & dosage ; Mifepristone ; administration & dosage ; Pregnancy ; Pregnancy, Ectopic ; drug therapy ; Randomized Controlled Trials as Topic ; Treatment Outcome

The purpose of this study was to investigate knowledge and attitude about oral contraceptive between Korean and Japanese university students in order to provide better sex education programs and direcrion.Korean subjects of this study were 337 university students in M city, during the period from April 1 to April 20, 2001 and Japanese subjects 245, during the period from June to August, 2001. Collected data were analyzed using descriptive statistics, t-test, Pearson correlation coefficients with SPSS package. The results from this study were summarized as follows :1. The mean age of Koreans and Japanese students was 21.0+/-3.2 and 19.6+/-3.2 years old. The number of Japaneses youths having the parter with sexual intercourse was larger than that of Korean university students. 2. Comparison of knowledge and attitude about oral contraceptives between Korean and Japanese university students ;1) Comparison of sexual differences : Oral contraceptives related knowledge of Korean university students marked 55.7+/-7.5 of male students and 56.7+/-6.2 of females with a range of 15 to 75. The level of female students' knowledge was higher than that of male's but there is not statistically a significant difference (p= .080). Oral contraceptives related attitude of Korean university students marked 81.1+/-12.2 of male students and 76.9+/-10.3 of female's with a range of 24 to 120. The level of male students' attitude was higher than that of female's and there is statistically a significant difference(p= .002). Oral contraceptives related knowledge of Japanese university students marked 55.3+/-6.7 of male students and 57.0+/-6.3 of female students. The level of female students' knowledge was higher than that of male's but there is not statistically a significant difference (p= .159). Oral contraceptives related attitude of Japanese university students marked 80.3+/-10.1 of male students and 80.4+/-9.9 of female students. The level of female students' attitude was higher than that of male's and there is not statistically a significant difference(p= .928).2) Comparison between the country : Oral conceptives related knowledge of Korean university students marked 56.2+/-6.8 and 56.7+/-6.4 of Japanese university students with a range of 15 to 75. The level of Japanese university students' knowledge was higher than that of Korean's but there is not statistically a significant difference(p= .361). Oral conceptives related attitude of Korean university students marked 78.9+/-11.4 and 80.4+/-9.9 of Japaneses with a range of 24 to 120. The level of Japanese university studentss' attitude was higher than that of Korean's and there is not statistically a significant difference(p= .100). 2. Wanted age of oral contraceptives taking medicine and age was correlated positively (r=.178, p=.004) and total knowledge score of oral contraceptives and total attitude score were correlated positively(r=.467 p= .000) in Korean university students. Wanted age of oral contraceptives taking medicine and age was correlated positively (r=.289, p=.004), age and total attitude score were correlated positively(r=.196 p=.002) and total knowledge score of oral contraceptives and total attitude score were correlated positively (r=.671 p=.000) in Japanese university students. 3. Korean university students lifted side effect by the greatest factors in investigation about leading person that disturb work oral contraceptive, and the following appeared by knowledge insufficiency, sexual feeling inflammation worry, social prejudice, sexual morality decline, supernumerary prescription being not right, other person reverse and economical burden. Japanese university students can know that it is appearing by side effect, supernumerary prescription being not right, knowledge insufficiency, sexual feeling inflammation worry, economical burden, social prejudice, sexual morality decline and other person reverse. Think that this is result by dissimilar health medical system and cultural difference between two countries.
Adolescent ; Asian Continental Ancestry Group* ; Coitus ; Contraceptive Agents ; Contraceptives, Oral ; Female ; Humans ; Inflammation ; Male ; Morals ; Prejudice ; Prescriptions ; Sex Education

It has become more and more urgent to develop a safe, effective, recoverable and acceptable contraceptive for males. Decades of studies have made much progress on male hormonal contraception, one of the promising contraceptive methods. The principle is based on the suppression of pituitary gonadotropin and intratesticular testosterone, then the suppression of spermatogenesis, and the supplement of androgen to maintain the male characteristics and sexual function. There are many male hormonal contraceptive methods being studied include androgen, androgen combined with progesterone, GnRH antagonists combined with androgen, as well as immunological methods. To develop a safe and convenient androgen preparation with longer action and fewer side effects is also one of the key items of present research in this field.
Androgens ; Animals ; Contraception ; methods ; Contraceptive Agents, Male ; Contraceptives, Oral, Hormonal ; Humans ; Male ; Mice ; Progestins ; Rats ; Sheep

AIM: To evaluate the antifertility activity of Artemisia vulgaris leaves on female Wistar rats. METHOD: The plant extract was tested for its effect on implant formation at two dose levels, 300 and 600 mg·kg⁻¹, respectively. The effective methanolic plant extract was further studied for estrogenic potency on ovariectomised immature female Wistar rats. RESULTS: The data presented in this study demonstrate the antifertility potential of Artemisia vulgaris methanolic leaf extract, which shows a strong and significant decrease in implant formation (100%), and a strong estrogenic effect resulting in a significant increase in uterine weight in immature ovariectomised rats. These observations suggest that the methanolic extract of Artemisia vulgaris leaves has strong anti-implantation activity and estrogenic activity. CONCLUSION The methanolic plant extract of A. vulgaris has antifertility activity.
Animals ; Artemisia ; Contraceptive Agents ; pharmacology ; Embryo Implantation ; drug effects ; Female ; Fertility ; drug effects ; Organ Size ; Ovariectomy ; Phytoestrogens ; pharmacology ; Plant Extracts ; pharmacology ; Plant Leaves ; Rats, Wistar ; Uterus ; drug effects

Family planning is a very complex matter and has many ramifications so that one may expect a variety of problems besetting operation of family planning programs. One of the problems advocated so far is the drop-out rate or delinquent appointment rate of family planning clinics which is known to be as high as to deserve special attention. It is an urgent issue to be studied so that the family planning clinics could take measures to insure the continued optimal utilization of the services offered. Hence, the Nanakuli Family Planning Clinic was chosen as a sample to study and find out any differences and similarities between the "Delinquents" and "Non-delinquents" of the clinic, hoping that any meaningful facts brought out by this study could get the clinic to have the optimal utilization of the services by it's clients. Specific conclusions resulting from this study are the optimal utilization of family planning service by clients could not be expected without providing provisions for the biological, situational, and environmental problems of the clients as well as the administrative and managerial problems besetting the clinic operation itself.
Adolescent ; Adult ; Contraceptive Agents/supply & distribution ; Contraceptive Devices/supply & distribution ; Contraceptives, Oral/supply & distribution ; Family Planning/manpower ; Family Planning/utilization* ; Female ; Hawaii ; Human ; Middle Age ; Pregnancy

PURPOSE: The purpose of this study was to explore essences and meanings of using oral contraceptives among adult women. METHODS: The interview was conducted with 20 adult women who lived in Seoul, Gyeongi Province, Jeolla Province, Chungcheong Province, and Gangwon Province. Participants with the experience of using oral contraceptives for contraception were selected by convenience sampling. Semi-structured interviews were conducted for data collection. The data were analyzed using Colaizzi's method. RESULTS: Five themes revealed: ‘Lack of information and knowledge regarding oral contraceptives’, ‘Inconvenient and difficult purchase process of oral contraceptives’, ‘Pressure and fear regarding other people's reaction’, ‘Self-centered thinking toward the use of oral contraceptives’, ‘A need for a change in public awareness and policy’. CONCLUSION: A change in society's perception about oral contraceptives is required for safe contraceptives use. Therefore, it is necessary to educate the correct usage of oral contraceptives, and to develop a program for changing the paradigm of sex education.
Adult* ; Contraception ; Contraceptive Agents ; Contraceptives, Oral* ; Data Collection ; Female ; Gangwon-do ; Humans ; Methods ; Qualitative Research ; Seoul ; Sex Education ; Thinking

This study was a part of large scale of a prospective study on attitudes of professional students in medicine, nursing and teaching toward population related issues in Korea. The study was first conducted in May 1974 and then in May 1975 for the 1974 class cohot using a questionnaire consisted of attitude scales and other items developed by Lee. The purpose of study was two hold, namely, to determine the difference in students among specializations on one hand and between the first and second years in the 1974 class cohot regarding the subject matter. A one-way analysis of variance was used for attitude scale, and absolute and relative frequency were computed for the analysis of non-attitude scale items by employing Fishers' Ratio and Duncan's multiple range test at 5% level and chi square test at 5% level as significance tests. The hypothesis "students in health profession are more likely to have positive attitudes toward population related issues progressively as class year advances than students in teaching profession" was tested and the following results were obtained: 1) Nursing students were more likely to display favorable attitudes toward family planning than medical or teaching students although the class cohot showed slightly improved attitudes in the second year. 2) Respondents in general perceived national family planning program as a means of population control and this tendency was more true among nursing students as the class year advances than two other professional groups of students. Students in teaching profession appeared to perceive it more as a means to improve individual family welfare while health students were likely to see as to improve maternal and child health. This tendency was progressively improved as the class year advanced. 3) The majority of students regardless of their respective specializations believed that family planning program should be directed toward the improvement of individual family welfare. No progressive changes in the class cohot were observed. 4) About the plan to use contraceptives in future, no significant differences were observed among different specializations nor in different class years. However, the majority was confirmed to have a plan to use contraceptives in future. An increasing proportion of the undecided category was observed, as class year advanced among health students. 5) Students in health profession were found to be more favorable about "more leisure opportunities" as motive for limiting number of children whereas education students indicated the reasons as "facilitate ambitions" and "economic base". The progressive changes toward positive direction in both groups were observed as the class years advanced. 6) Attitudes toward induced abortions of the health student were observed to be positively related to class years while an inverse relationship was found in teaching students who showed much less favor in the subject matter than health students. This phenomenon may be due to the different exposure to learning environments unique to respective specializations. 7) Health students were found to have more favorable attitudes toward population education in general than the teaching students. The teaching students appeared to have changed more to the negative direction when they became the second year while no such development was observed in health students. The teaching students seemed to hold a very conservative position with regard to sex education on schools. 8) About the equality of sexes, the nursing group was found to be most favorable while the reverse was true in the teaching group. 9) About questions related to fertility values-the 10 percent of respondents regardless of specialization indicated that they would maintain their single status in future, however no change was observed in the second year. The desired number of children was found to be two by the majority of students in nursing, medicine and teaching in order of high proportion. No changes in a different class year were observed. The childless marriage was seen by nursing students as a problem more than other students, but a slight change in positive direction was found when the nursing students became the second year. In summing, as data supported in the above, students in health profession demonstrated more favorable attitudes toward population related issues than the teaching students were more conscious about the health aspect of population and family planning program while the teaching students gave more attention the socioeconomic aspect. The sex variable seemed to have operated in the item related to the equality of sexes. In conclusion, as data presented in the above, the hypothesis of this study was accepted except in the few items. It should be noted that the limitation of this study is the short duration of the observation in measuring the possible attitude changes. It should include curriculum analysis for the respective specializations in order to identify the area of curriculum impact on students in future study.
Abortion, Induced ; Child ; Child Health ; Contraceptive Agents ; Curriculum ; Surveys and Questionnaires ; Education ; Family Planning Services ; Female ; Fertility ; Hand ; Health Occupations ; Humans ; Korea* ; Learning ; Leisure Activities ; Marriage ; Nursing ; Population Control ; Prospective Studies* ; Surveys and Questionnaires ; Sex Education ; Students, Nursing ; Weights and Measures

BACKGROUND: There is a dearth of studies that explore the perceptions of male partners of adolescent females towards the intention of pursuing contraception.

OBJECTIVE: To determine the role of male partner perceptions in the intention to use of contraception among female adolescents to prevent unplanned repeat pregnancies.

MATERIALS AND METHODS: An urban sample of 102 male partners of female adolescents with previous pregnancy experience coming from the out-patient department and selected barangay health center responded to a two-part questionnaire that explored their perceptions towards contraception. Demographic data and their positive and negative views, attitudes and actual practice of contraception as it affects future intention to engage in family planning methods were determined.

RESULTS: Male sexual partners have positive perceptions towards contraception. Despite this, utilization rate was still low (56.8%). Positively correlated with contraceptive intention include the male partner's advanced age and high level of education. Perceptions that favor strong intention include careful pregnancy planning in the future, not wanting a pregnancy too soon, knowledge of a specific method, its perceived benefits, "shared decision" making, feeling "happy" when contraceptives are offered rather than forced and when a woman lacks trust in him. Forcing contraception by the female adolescent partner was negatively correlated with contraceptive intention.

CONCLUSION: Shared decision making towards contraception in order to reduce unintended pregnancies should engage the male partner's participation by correcting prevailing misperceptions.

Human ; Male ; Female ; Young Adult ; Adolescent ; Pregnancy ; Family Planning Services ; Contraceptive Agents ; Sexual Partners ; Outpatients ; Contraception ; Pregnancy, Unplanned ; Contraceptive Devices

Contraceptive Devices ; utilization ; Drugs, Chinese Herbal ; therapeutic use ; Endometriosis ; drug therapy ; surgery ; therapy ; Female ; Humans ; Medicine, Chinese Traditional ; Reproductive Control Agents ; therapeutic use