The acupuncture direction is closely related with the efficacy of acupuncture analgesia. In this article, the relationship between efficacy of acupuncture analgesia and factors, such as whether the needle towards disease location, whether the needle towards meridian direction, whether the needle following spinal cord direction and whether the needle following muscle direction, were analyzed. The previous clinical and literature research indicated that the needle towards disease location was superior to reverse direction, however, the efficacy of analgesia between needle following and reversing meridian, needle towards and at disease location, needles following and reversing spinal cord direction, needles following and reversing muscle direction was controversial. Therefore, the solutions to these problems will benefit the optimized acupuncture treatment plan for pain disorders.

Moxibustion at Guanyuan (CV 4) can produce biological effects, mainly including local effects, targeting organ effects, systemic effects. The biological effects of moxibustion at Guanyuan (CV 4) are related to stimulation parameters and health or pathological nature of the objects, and the effects show acupoint specificity. Its research of local effects should be attached importance to and the acupoint specificity needs to be ascertained, as well as the relationships between the biological effects and stimulation parameters, and between the effects and health or pathological nature of the objects.