1.Laser photodynamic therapy with hematoporphyrin derivative in tumor diagnosis
Hao LIU ; Meilan CHEN ; Renyu GUO
Journal of Xi'an Jiaotong University(Medical Sciences) 1982;0(04):-
Objective To investigate the efficacy of photodynamic therapy(PDT) for tumor diagnosis.Methods A total of 1 400 patients with the cervix of uterus disease,56 patients with gullet disease,133 patients with stomach diseases,37 patients with urinary bladder tumor and 14 patients with brain tumor underwent diagnosis with PDT,combination of He-cd laser,Ar+ laser,and KTP laser.Results All of the patients could be explicitly diagnosed by this method,which indicated that PDT helped greatly in early tumor diagnosis. Conclusion PDT can be an effective diagnostic method for tumors of early stage,and should be widely applied clinically.
2.ROLE OF GLUCAGON IN THE PATHOGENESIS OF NIDDM
Renyu LIU ; Yonghe MIAO ; Jimin WANG
Chinese Journal of Endocrinology and Metabolism 1985;0(01):-
In order to probe into the role of plasma glucagon in the pathogenesis of NIDDM, the concentrations of fasting blood glucose, serum insulin and plasma glucagon were assayed in 327 subjects with normal glucose tolerance (group Ⅰ), 25 patients with NIDDM (group Ⅱ) and 20 NIDDM patients treated with drugs (group Ⅲ). The levels of blood glucose, plasma glucagon and serum insulin in group Ⅱ were 9. 28?2.30 mmol/L,159. 55?34. 13ng/L and 15. 16?10. 79mIU/L respectively, and were significantly higher than those of group Ⅰ(4. 71?0. 64mmol/L,83.12?12.39ng/L and 10. 43?6. 86mIU/L respectively). The levels of blood glucose and plasma glucagon in group Ⅲ were 7. 15?2. 44 mmol/L and 124. 99?37. 23 ng/L respectively and were lower than those of group Ⅱ, no significant difference in serum insulin levels was noted. Correlation analysis showed that blood glucose had a positive linear correlation with plasma glucagon in the three groups (r=0. 8720,0. 9400,0. 8731,respectively, P
3.Investigation of KGF and KGFR expression in external auditory canal skin adjacent to tympanic membrane perforation
Lian FANG ; Renyu LIN ; Jili LIU ; Juan HONG
Chinese Archives of Otolaryngology-Head and Neck Surgery 2006;0(04):-
OBJECTIVE To investigate the continuous expression of keratinocyte growth factor(KGF)and keratinocyte growth factor receptor(KGFR)in external auditory canal skin adjacent to tympanic membrane perforation and analyze the role of KGF and KGFR in the different turnover of chronic otitis media.METHODS The external auditory canal skin adjacent to tympanic membrane perforation from 20 cases with cholesteatoma otitis media and the corresponding cholesteatoma tissue and normal external ear skin were examined by immunohistochemical S-P method and quantitative analysis.The positive rate was compared with 20 cases of non-cholesteatom otitis media's external auditory canal skin adjacent to tympanic membrane perforation.RESULTS The staining for KGF and KGFR in cholesteatoma otitis media's external auditory canal skin adjacent to tympanic membrane perforation was consistently stronger than that in non-cholesteatoma otitis media.The positive rates of the two tissue was(33.135?6.364)% and(19.965?10.570)%,(19.380?2.827)% and(13.145?7.935)% respectively,revealing a significant difference.CONCLUSION The activity of hyperproliferation of the external auditory canal skin adjacent to tympanic membrane perforation in cholesteatoma otitis media is stronger than that of non-cholesteatoma otitis media.KGF and KGFR may play a more important role for hyperproliferation of cholesteatoma.
4.Comparision of risk factors and pathogens in patients with early-and late-onset ventilator-associated pneumonia in intensive care unit
Yingjian LIANG ; Zhiliang LI ; Liang WANG ; Baoyan LIU ; Renyu DING ; Xiaochun MA
Chinese Journal of Internal Medicine 2017;56(10):743-746
Objective To compare risk factors and bacterial etiology in patients with early-onset versus late-onset ventilator-associated pneumonia (VAP) in intensive care unit (ICU).Methods This prospective cohort study enrolled mechanically ventilated patients hospitalized for more than 48 hours in the first affiliated hospital,China Medical University from Jan 2012 to Jun 2016.Subjects were classified by ventilator status:early-onset VAP (< 5 d ventilation,E-VAP) or late-onset VAP (≥ 5 d ventilation,L-VAP).Potential risk factors and pathogen were evaluated.Results A total of 4 179 patients in adult ICU were screened,3 989 (95.5%) of whom were mechanically ventilated,962 patients with mechanical ventilation time ≥ 48 h.VAP developed in 142 patients.E-VAP and L-VAP had different potential risk factors based on statistical analysis.Independent risk factors for E-VAP included male (OR =1.825,95% CI 1.006-3.310),chronic obstructive pulmonary disease (COPD;OR =3.746,95% CI 1.795-7.818),emergency intubation (OR =1.932,95% CI 1.139-3.276),aspiration (OR =3.324,95% CI 1.359-8.130).Whereas independent risk factors for L-VAP were coma (OR =2.335,95% CI 1.300-4.194),renal dysfunction (OR =0.524,95% CI O.290-O.947),emergency intubation (OR =2.184,95% CI 1.334-3.574).Mortality in E-VAP and L-VAP group were both higher than the non-VAP group[30.2%(19/63)vs 19.8% (162/820),P=0.044;29.1% (23/79) vs 19.8%(162/820),P=0.046].The pathogens isolated from early-onset versus late-onset VAP were not significantly different between groups,which the most common ones were acinetobacter baumannii,pseudomonas aeruginosa and klebsiella pneumoniae.Conclusion E-VAP and L-VAP have different risk factors,however related pathogens are similar.Different specific preventive strategies are suggested based on different onset of VAP.
5.Efficacy and safety of Wanfeile in the treatment of erectile dysfunction: Report of 100 cases and review of the literature.
Wen-Jun CHEN ; Jing CAO ; Xuan-Wen ZHU ; Zhen SUN ; Qiang FU ; Xiao-Lin LIU
National Journal of Andrology 2017;23(5):448-451
Objective:
To investigate the clinical effect and safety of Wanfeile in the treatment of erectile dysfunction (ED).
METHODS:
Totally 100 ED patients received oral Wanfeile at 100 mg, once every 3 days, for a course of 3 months. We compared the IIEF-5 scores of the patients before and after medication and among the patients with different degrees of ED. We evaluated the total clinical effectiveness of Wanfeile and analyzed adverse reactions.
RESULTS:
The total effectiveness rate of Wanfeile was 95.6%. All the patients showed significant improvement in the IIEF-5 scores after treatment as compared with the baseline (P <0.05). Adverse reactions were observed in 5 cases (5.50%), all mild and transient.
CONCLUSIONS
Wanfeile is safe and efficacious for the treatment of ED.
Double-Blind Method
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Drug Administration Schedule
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Erectile Dysfunction
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drug therapy
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Humans
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Male
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Phosphodiesterase 5 Inhibitors
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administration & dosage
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adverse effects
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Sildenafil Citrate
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administration & dosage
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adverse effects
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Surveys and Questionnaires
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Treatment Outcome
6.Current status and prospect of biomarker research for schizophrenia
Mengyuan ZHU ; Qing CHEN ; Dan LI ; Mengxia WANG ; Renyu WANG ; Yuxin ZHU ; Weifeng JIN ; Shuzi CHEN ; Ping LI ; Zhenhua LI ; Peijun MA ; Shuai LIU ; Qiong GAO ; Xiaoyan LOU ; Jie XU ; Lili ZHU ; Ling ZHAO ; Kangyi LIANG ; Jinghong CHEN ; Xunjia CHENG ; Ke DONG ; Xiaokui GUO ; Qingtian LI ; Yun SHI ; Junyu SUN ; Huabin XU ; Ping LIN
Chinese Journal of Laboratory Medicine 2022;45(11):1191-1196
Schizophrenia is a serious mental disease. The diagnosis of schizophrenia so far relies heavily on subjective evidence, including self-reported experiences by patients, manifestations described by relatives, and abnormal behaviors assessed by psychiatrists. The diagnosis, monitoring of the disease progression and therapy efficacy assessment are challenging due to the lack of established laboratory biomarkers. Based on the current literature, clinical consensus, guidelines, and expert recommendations, this review highlighted evidence-based potential laboratory biomarkers for the diagnosis of schizophrenia, including genetic biomarkers, neurotransmitters, neurodevelopmental-related proteins, and intestinal flora, and discussed the potential future directions for the application of these biomarkers in this field, aiming to provide an objective basis for the use of these biomarkers in the early and accurate diagnosis, treatment, and prognosis and rehabilitation assessment of schizophrenia.
7.Adoptive cell transfer therapy for hepatocellular carcinoma.
Renyu ZHANG ; Zhao ZHANG ; Zekun LIU ; Ding WEI ; Xiaodong WU ; Huijie BIAN ; Zhinan CHEN
Frontiers of Medicine 2019;13(1):3-11
Hepatocellular carcinoma (HCC) is one of the most common cancers worldwide. This malignancy is associated with poor prognosis and high mortality. Novel approaches for prolonging the overall survival of patients with advanced HCC are urgently needed. The antitumor activities of adoptive cell transfer therapy (ACT), such as strategies based on tumor-infiltrating lymphocytes and cytokine-induced killer cells, are more effective than those of traditional strategies. Currently, chimeric antigen receptor T-cell (CAR-T) immunotherapy has achieved numerous breakthroughs in the treatment of hematological malignancies, including relapsed or refractory lymphoblastic leukemia and refractory large B-cell lymphoma. Nevertheless, this approach only provides a modest benefit in the treatment of solid tumors. The clinical results of CAR-T immunotherapy for HCC that could be obtained at present are limited. Some published studies have demonstrated that CAR-T could inhibit tumor growth and cause severe side effects. In this review, we summarized the current application of ACT, the challenges encountered by CAR-T technology in HCC treatment, and some possible strategies for the future direction of immunotherapeutic research.
Adoptive Transfer
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methods
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Carcinoma, Hepatocellular
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immunology
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therapy
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Humans
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Immunotherapy, Adoptive
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methods
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Liver Neoplasms
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immunology
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therapy
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Lymphocytes, Tumor-Infiltrating
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cytology
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Randomized Controlled Trials as Topic
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Receptors, Chimeric Antigen
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T-Lymphocytes
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cytology
8.Expert consensus on the diagnosis and treatment of severe and critical coronavirus disease 2019.
You SHANG ; Jianfeng WU ; Jinglun LIU ; Yun LONG ; Jianfeng XIE ; Dong ZHANG ; Bo HU ; Yuan ZONG ; Xuelian LIAO ; Xiuling SHANG ; Renyu DING ; Kai KANG ; Jiao LIU ; Aijun PAN ; Yonghao XU ; Changsong WANG ; Qianghong XU ; Xijing ZHANG ; Jicheng ZHANG ; Ling LIU ; Jiancheng ZHANG ; Yi YANG ; Kaijiang YU ; Xiangdong GUAN ; Dechang CHEN
Chinese Medical Journal 2022;135(16):1913-1916
Humans
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COVID-19
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Consensus
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SARS-CoV-2
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China