Objective To observe the effects of modified Yigong Powder (MYP) combined with chemotherapy on transplanted hepatocarcinoma of mice and to study its mechanisms. Methods Hepatocarcinoma 22 mouse model was established and then was used to observe the attenuating and synergic effects of MYP when applied together with 5-fluorouracil (5-FU). After 8 days of treatment,the tumor-inhibiting rate,activity of natural killer (NK)cells and interleukin-2 (IL-2) and small intestinal malondialdehyde (MDA) content were examined. Results MYP combined with 5-FU could increased the tumor-inhibiting rate to some extent and improve the immune function by increasing immune organ weight and increasing the activity of NK cells and IL-2. MYP combined with 5-FU could also reduce the 5-FU-induced intestinal injuries by relieving the damage of free radicals and inhibiting the lipid peroxidation and a good prognosis was expected in tumor-bearing animals treated with chemotherapy. Conclusion MYP exerts an attenuating and synergic effect when used together with 5-FU in treating tumor-bearing mice and its mechamism may be related to the improvement of immune function and reduction of intestinal injuries.

OBJECTIVETo investigate the effect of three different impression methods on the marginal fit of all-ceramic crowns. The three methods include scanning silicone rubber impression, cast models, and direct optical impression.

METHODSThe polymethyl methacrylate (PMMA) material of a mandibular first molar in standard model was prepared with 16 models duplicated. The all-ceramic crowns were prepared using three different impression methods. Accurate impressions were made using silicone rubber, and the cast models were obtained. The PMMA models, silicone rubber impressions, and cast models were scanned, and digital models of three groups were obtained to produce 48 zirconia all-ceramic crowns with computer aided design/computer aided manufacture. The marginal fit of these groups was measured by silicone rubber gap impression. Statistical analysis was performed with SPSS 17.0 software.

RESULTSThe marginal fit of direct optical impression groups, silicone rubber impression groups, cast model groups was (69.18±9.47), (81.04±10.88), (84.42±9.96) µm. A significant difference was observed in the marginal fit of the direct optical impression groups and the other groups (P<0.05). No statistically significant difference was observed in the marginal fit of the silicone rubber impression groups and the cast model groups (P>0.05).

CONCLUSIONAll marginal measurement sites are clinically acceptable by the three different impression scanning methods. The silicone rubber impression scanning method can be used for all-ceramic restorations.

Computer-Aided Design ; Crowns ; Dental Marginal Adaptation ; Dental Porcelain ; Dental Prosthesis Design ; Zirconium

Objective??To?investigate?the?effect?of?three?different?impression?methods?on?the?marginal?fit?of?all-ceramic?crowns.?The?three?methods?include?scanning?silicone?rubber?impression,?cast?models,?and?direct?optical?impression. Methods?The?polymethyl?methacrylate?(PMMA)?material?of?a?mandibular?first?molar?in?standard?model?was?prepared?with?16?models?duplicated.?The?all-ceramic?crowns?were?prepared?using?three?different?impression?methods.?Accurate?impressions?were?made?using?silicone?rubber,?and?the?cast?models?were?obtained.?The?PMMA?models,?silicone?rubber?impressions,?and?cast?models?were?scanned,?and?digital?models?of?three?groups?were?obtained?to?produce?48?zirconia?all-ceramic?crowns?with?computer?aided?design/computer?aided?manufacture.?The?marginal?fit?of?these?groups?was?measured?by?silicone?rubber?gap?impression.?Statistical?analysis?was?performed?with?SPSS?17.0?software.?Results??The?marginal?fit?of?direct?optical?impression?groups,?silicone rubber impression groups, cast model groups was (69.18±9.47), (81.04±10.88), (84.42±9.96)μm. A significant diffe-rence?was?observed?in?the?marginal?fit?of?the?direct?optical?impression?groups?and?the?other?groups?(P<0.05).?No?statistically?significant?difference?was?observed?in?the?marginal?fit?of?the?silicone?rubber?impression?groups?and?the?cast?model?groups?(P>0.05).?Conclusion??All?marginal?measurement?sites?are?clinically?acceptable?by?the?three?different?impression?scanning?methods.?The?silicone?rubber?impression?scanning?method?can?be?used?for?all-ceramic?restorations.

Objective:To explore the clinical characteristics of early death in adult patients with hemophagocytic syndrome (HPS).Methods:The clinical data of 53 adult HPS patients in Xianning Central Hospital, Huangshi Central Hospital and Tongji Hospital Affiliated to Tongji Medical College of Huazhong University of Science and Technology from September 2016 to November 2021 were retrospectively analyzed, and the patients were grouped according to whether they died within 28 d after diagnosis. The clinical characteristics of the two groups were compared. A multivariate analysis of patients' death within 28 d was performed using logistic regression.Results:In 53 adult HPS patients, the mortality rate within 28 d was 28.3% (15/53). The survival time of patients was related to white blood cell count ( r = 0.324, P = 0.018), total bilirubin level ( r = -0.280, P = 0.042) and albumin level ( r = 0.281, P = 0.042), but there was no linear causality (all P > 0.05). When compared between the death within 28 d group and the non-death within 28 d group, the differences in patients' age, platelet count, albumin level, creatine kinase isoenzyme level, triacylglycerol level, ferritin level, and central nervous system involvement were statistically significant (all P < 0.05). Multivariate logistic regression analysis showed that platelet count <30×10 9/L, albumin <30 g/L, central nervous system involvement, and ferritin ≥10 000 ng/ml were independent risk factors for patients' death within 28 d (all P < 0.05). Conclusions:In adult HPS patients, assessing the risk of early death based on ferritin level, platelet count, albumin level, and neurological symptoms, actively correcting internal environmental disturbances, and enhancing organ support therapy can contribute to survival benefit.