Objective:To develop training course about care of the dying for cancer patients based on the CARES framework and explore its clinical application effect.Methods:Based on the CARES framework, the first draft of training course about care of the dying for cancer patients was constructed. From November 2021 to January 2022, the Delphi method was used to conduct two rounds of expert correspondence with 23 experts nationwide, forming the final version of training course about care of the dying for cancer patients. From January to March 2022, 235 oncology nurses from Beijing Cancer Hospital were selected as research objects by the convenient sampling method, and were given training course about the care of the dying for cancer patients. The Evaluation Questionnaire on Training Course about Care of the Dying for Cancer Patients was used to evaluate the satisfaction of nurses to the course setting and implementation.Results:The final training course about care of the dying for cancer patients included 7 first-level indicators, 16 second-level indicators and 44 third-level indicators. The overall satisfaction rate of training course about care of the dying for cancer patients in oncology nurses was 100.00% (235/235) .Conclusions:The development process of training course about care of the dying for cancer patients based on CARES framework is standardized, and the students have high satisfaction with the course setting and implementation process, which can be used as an educational resource for clinical nurses to improve professional nursing ability in the dying period.