AIM To investigate the mices central nerve system function and the effect of drugs through independent activity pattern observation. METHODS By observing the influence of drugs on the independent activity patterns of mice of different testing time and testing times, sex, sound, and brightness. RESULTS The mices independent activity is related to testing times, sound and drugs applied, but not related to testing interval, sex, and brightness. CONCLUSION Individual difference of the independent activity of mice is great. The quietness of the experimental environment influences the result.

ObjectiveTo study the effect of “Six Healing Sounds” by analizing the changes of physical condition and stamina of the patients after using it.MethodsAll volunteers were divided into two groups:the exercise group and the contrast group,studied the idexes of physical conditions before and after 6 month exercise.ResultsAfter 6 months,the data of weight and BMI of those who were in the exercise group was getting lower,together with their physical condition and ability to motion getting better.Conclusion“Six Healing Sounds” is good for keep fit and provide a better physical condition for people.

Objective To evaluate the effect of “Six Healing Sounds” on brain's mechanism by analyzing the changes of patients' cerebral electric power.Methods All volunteers were randomly recruited into two groups:exercise group and contrast group.“nerve-physiology information workstation” was setup to record the changes of cerebral electric powder of both groups before and 6 months after the treatment.The data was further analyzed by “intelligent cerebral powder analyzing system”.Results Frequency changes:in the exercise group after 6 months:α1 (0.3959±0.2332)μv2 and α2(0.1531 ±0.11609μv2)were both increased,while δ (0.0951 ±0.0604) μv2、θ (0.2515±0.1165) μv2、β1 (0.0934±0.0483) μv2 and β2 (0.0111 ±0.0068) μv2 were reduced.While in the contrast group after 6 month:all values were similar to those 6 months ago.Space changes:in the contrast group after 6 months:all values were similar to those 6 months ago; while in the exercise group after 6 months:it had tremendous changes in such areas as FP2 (2.0711 ± 1.6765 )、F3 ( 1.8586± 1.6321 )、C3 (1.7756± 1.3104); and slight changes in F4 ( 1.9610±1.4332)、P3 ( 1.5587±1.2798)、P4 (1.6108± 1.2521 )、01 ( 1.1383 ±0.9343)、02( 1.2555±1.0694)、T3 ( 1.8961 ±1.5900) and T4 (2.0190±1.6374).Conclusion “Six Healing Sounds” therapy can improve the functional status of the brain.

Objective To observe the rehabilitation of “Six Healing Sounds” on mild anxiety disorders of the old and middle-aged persons.Methods All patients were randomly divided into “Six Healing Sounds” exercise group and control group using random number table.Self-Rating Anxiety Scale (SAS),Hamilton Anxiety Scale (HAMD) were adopted for evaluating the efficacy of the subjects before and three months after the practice.“Nerve-physiology information workstation” was setup to record the changes of cerebral electric powder of both groups before and 3 months after the treatment.The data was further analyzed by “intelligent cerebral powder analyzing system”.Results ①After three months practice,clinical efficacy shwoed significant difference between the two groups (exercise group 66.67％,control group 26.19％.HAMA(12.440±4.104) and SAS (36.355±15.085) score decreased significantly after the treatment in the exercise group.HAMA score,the SAS score and HAMA reduction rate (26.3±23.8)％ had significant difference between the two group.②)Frequancy changes:the change of β1 (0.1005±0.0132) μν2 before and after the exercise in the exercise group showed significant difference than that in the control group.③Space changes:in the exercise group after 3 months:F3(3.7449±3.0739),F4(3.9948±3.5865),P4(2.6442±1.7867),O1 (2.5845 ± 1.7883),T4(2.7916 ± 2.0327)were increased than before; Fpl (5.4771 ± 3.9768),Fp2 (5.8682 ± 3.8109),O2 (4168 ± 2.9227 ) were increased than before; comparison between the exercise group and control group:Fp1、Fp2、F3、F4、P4)、O1、T4Fp1 (3.8686±3.2034),Fp2(3.9419±3.4709),F3(2.5632±2.0258),F4(2.6763±2.2542),P4(1.7535± 1.7334),O1(1.6426± 1.5885),T4(1.8626± 1.7103) in the exercise group were obviously increased; O2 (1.8942± 1.8346)was significantly increased in the exercise group.Conclusion “Six Healing Sounds” had rehabilitation effects on anxiety disorders of the middle-aged persons.

Objective To observe the effect ofSix Healing Sounds on mild anxiety disorders of the old and middle-aged persons.Methods Randomly divided the volunteers into a exercise group and a contrast Group.WHOQOL-BRIE was adopted for evaluating the efficacy of the subjects before and six months after the practice.Results After 6 months practice,quality of life subjective feeling score (3.59±0.69),subjective feeling of health status score(3.22± 0.96),physical domain score( 89.19 ± 1 3.68 ) and psychological field score (79.74± 11.26) in the exercise group were significantly increased than the contrast group (P＜0.01).The scores of quality of life subjective feeling,subjective feeling of health status,physical domain,and psychological field were increased in the exercise group after 6 months treatment than before (P＜0.01).Conclusion The Six Healing Sounds can improve the quality of life of the old and middle-aged persons.

Objective To observe the rehabilitation of Six Healing Sounds on MCI of the oldaged persons.Methods All patients were randomly divided into Six Healing Sounds exercise group and control group using random number table.MOCA,and MMSE were adopted for evaluating the efficacy of the subjects before and six months after the practice.Nerve-physiology information workstation was setup to record the changes of cerebral electric powder of both groups before and 6 months after the treatment.The data was further analyzed by intelligent cerebral powder analyzing system.Results ①After six months practice,total score of MOCA (25.18 ± 5.07) and MMSE (26.03 ± 2.63) increased significantly after the treatment in the exercise group,which showed significant difference than the control group [MOCA (22.83 ± 4.95) and MMSE (24.86± 2.98)].MOCA increased significantly in attention (5.04 ± 0.90),delay memory (3.02 ± 0.89),verbal(2.30±0.57) sub-item scores after the treatment in the exercise group,showed significant differences than the control group [attention (4.28 ± 1.08),delay memory (2.33 ± 0.95),verbal (2.13 ± 0.51)] ; MMSE also demonstrated a significant increase a in split-second memory(2.35 ±0.43),delay memory(2.42±0.48),verbal (8.49± 0.54) sub-item scores after the treatment in the exercise group,showed significant differences than the control group [split-second memory (2.15 ± 0.34),delay memory (2.14± 0.83),verba (8.13 ± 0.70)].②Frequency changes:the change of δ (0.0848± 0.0373) μ v 2 was decreased than before in the exercise group after 6 months; the change of α1 (0.3753± 0.1470) μ v2was increased than before in the exercise group after 6 months; the change ofδ and θ (0.2266±0.0953)μ v2 had significant difference after the treatment between the two group [control group:δ (0.1095 ± 0.0520) μ v2 θ (0.2589 ± 0.0862) μ v 2and α1 (0.3160 ±0.1540)μ v 2].③Space changes:in the ratio of (δ + θ) / (α1+α2+β1+β2):F4(0.5115±0.4262)、O 1 (0.3365 ± 0.2436)、O2 (0.3536± 0.2671)、T4 (0.4581 ± 0.3798)、T5 (0.3198± 0.3608)、Fp (10.8233 ±0.6857) 、Fp2 (0.7710± 0.6352)、C3 (0.3702 ± 0.3910)、C4 (0.3896 ± 0.3523)、P4 (0.3523 ± 0.2333)、T6 (0.2972± 0.4276)were decreased than before in the exercise group after 6 months; C3、C4、P4、T4、T5 、T6、Fpl had significant difference after the treatment between the two group[control group:C3 (0.5706±0.4944)、C4 (0.5780 ± 0.4996)、P4 (0.4835 ± 0.3641)、T4 (0.6294 ± 0.4186)、T5 (0.4882 ± 0.4000)、T6 (0.4879±0.4131)、Fp1 (1.0125±0.7476)].Conclusion Six Healing Sounds had rehabilitation effects on MCI of the old-aged persons.