Objective To evaluate the effects of low dose intravenous minocycline postconditioning on myocardial ischemia-reperfusion injury in rat,and to investigate the possible mechanisms. Methods Forty-eight male wistar rats were randomly divided into four groups:sham-operation (SO)group,ischemia-reperfusion(IR)group,low-dose minocycline(3 mg/kg,LM)group and high-dose minocycline(10 mg/kg,HM)group. The rat model of myocardial IR was established by occlusion of the left anterior descending coronary artery for 45 minutes and reperfusion for 120 minutes.After the reperfusion,the parameters of haemodynamics were recorded;creatine kinase MB(CK-MB),cardiac troponin-I(cTn-I),malond-ialdehyde(MDA),superoxide dismutase(SOD)in serum and myocardium,myocardial apoptosis index(AI)and the myocardial tissue morphology were determined. Results Compared with IR group,LM and HM treatment significantly reduced the levels of CK-MB form,cTn-I,AI and MDA, lowered LVEDP,enhanced LVSP and ±dp/dtmax,elevated the activity of SOD in serum and myocardium(P<0.05). The effect of HM is stronger than LM on these above mentioned indicators,but the difference was not statistical significance(P>0.05). Conclusion LM postconditioning can protect against myocardial IR injury,and the protective effect may be related to the scavenging of oxide free radical,which further restrain the reac-tion of lipid peroxidation and apoptosis.

Objective To investigate the current status of moral distress in clinical nurses,and analyze its influential factors.Methods A total of 240 clinical nurses were recruited by stratified sampling method.They were investigated with general situation questionnaire and moral distress scale.Results The average score of moral distress was (2.66±0.41).Multiple linear regression analysis showed that department of work and qualification were influencing factors on moral distress of clinical nurses.Conclusions This study found that nurses' moral distress was above the middle level.Some targeted measures should be taken by nursing managers,in order to help decrease nurses' moral distress.

Objective To investigate the status of health promoting lifestyles in nursing students , and to analyze its influencing factors .Methods Three hundred and seventeen nursing students were chosen according to cluster sampling method , and the cross-sectional study was carried out through the health promoting lifestyle profileⅡ( HPLPⅡ) and self-esteem scale .Results The average score of all items of health promoting lifestyle was (2.33 ±0.32), and the highest score was (2.63 ±0.29) (self-realization), and the lowest score was (2.04 ±0.33) (exercise).The difference was found in the health promoting lifestyles in different nursing students including different age , grade, living conditions and school satisfaction (P<0.05).The average score of self-esteem was (22.91 ±4.20), and the correlation analysis showed that the score of health promoting lifestyle was positively correlated with self-esteem (r =0.517, P<0.05).The major influencing factors of health promoting lifestyle were respectively self-esteem, school satisfaction and age , which can explain 19.7%of the variance in health promoting lifestyles .Conclusions Self-esteem may be an important factor of health promoting lifestyles in nursing students , and the improvement of self-esteem can help them to take positive health promoting lifestyle .

Immune checkpoint inhibitors(ICIs)are an emerging tumor treatment approach following traditional surgery,chemoradiotherapy and targeted therapy.They have proven to be effective in a variety of cancers.However,they may induce immune-related adverse events(irAEs)during treatment,which may affect patients'quality of life and lead to treatment interruption or cessation.The key to preventing irAEs is early evaluation and identification of medical staff.Therefore,this article reviews the clinical manifestations and influencing factors of irAEs to help the early identification of high-risk groups and provide reference for clinical nursing work.