Objective To master the prevalence of H unan Immunodeficiency Virus (HIV),hepatitis C virus (HCV)and syphilis (RPR)infection and influencing faictors in Liucheng County,Guangxi Province,provided scientific basis for reducing the infection rate among drug users.Methods Analysis of 2011-2015 surveillance data of AIDS sentinel population.Results Male infection is more than female.The ratio of male to female is 1:0.072;The number of male infected with 2011-2015 in each year is 10 times that of female.The affect people between 20 to49 years old was higher than that of others,accounted for 93.66 ％ of the total number of infections.The ntmber of HIV and the number of HCV were downgrade year by year.The number of RPR was at the same level each year.HIV infection between 20 to 29 years old was lower than that of between 30 to 39 and 40 to 49 years old in HIV-infected people.HIV infection between 30 to 39 years old was lower than that of between 4(to 49 years old.The difference was statistically significant(P＜0.01).HCV infection between 20 to 29 years old was lower than that of between 30 to 39 and 40 to 49 and 50 to 59 years old in HCV-infected people.The difference was statistically significant(P＜0.01).RPR infection between 20 to 29 years olt was lower than that of between 30 to 39 and 40 to 49 years old in RPR-infected people.The difference was statistically significant(P＜0.01).Conclusion To strengthen the detection of drug users and behavior intervention,reduce the harm of AIDS,protect the health and safety of the people,is an important way to curb the prevalence of AIDS.