1.Clinical observation of different concentrations of ropivacayin combined with dezocine for Epidural analgesia
Clinical Medicine of China 2012;28(7):739-741
Objective To investigate the analgesic effect and motor block of ropivacayin combined dezocine in lower abodiminal operation.Methods Sixty patients of ASA Ⅰ - Ⅱ were divided into three groups randomly(n =20 for each group).They were treated with dezocine 5 mg +0.125% ropivacayin/100 ml( group DI ),dezocine 5 mg +0.175% ropivacayin/100 ml( group D2),dezocine 5 mg +0.225% ropivacayin/100 ml (group D3 ).The initial dose was 5 ml,and the maintenance dose was 2 ml/h,with lock-out time of 20 mins,and the duration of patient-controlled epidermal analgesia (PCEA) was 48 h.The analgesic effect was evaluted by VAS score at 2,4,12,24 and 48 h after surgery.Bromage score and the side effects such as motor ability,and vomiting after surgery were recorded.Results At 2,4,12 h after surgery,the VAS scores of group D2 and D3 were less than that of group D1 (2.54 ± 1.34,2.47 ± 1.05 and 3.62 ± 1.02 at 2 hrs,2.13 ± 1.30,2.15 ± 1.28 and 3.56 ± 1.10 at 4 hrs,1.03 ± 0.43,1.04 ± 0.51 and 1.92 ± 1.20 at 12 hrs,respectively) ( Ps < 0.05 ).As for the Bromage score among the 3 groups,there were no sighificant diffrences between group D1 and D2,wheras they were significantly lower than that in group D3 ( 1.21 ± 0.21,1.28 ±0.22 and 1.53 ± 0.31 at 2 hrs,1.15 ± 0.15,1.44 ± 0.25 and 1.61 ± 0.12 at 4 hrs,0.92 ± 0.14,0.99 ± 0.13 and 1.71 ± 0.22 at 12 hrs,0.85 ± 0.11,0.88±0.14 and (1.66±0.15) at 24 hrs,0.42 ± 0.10,0.55 ± 0.09 and 1.19±0.11 at 48 hrs,respectively,Ps <0.05).There were 2,2 and 3 patients affected with nausea and vomiting among the 3 groups,and there were no other side effects ( P > 0.05 ).Conclusion 0.175% ropivacayin combined with dezocine 5 mg via PCEA in lower abodiminal operation shows better analgesic effect and benefical to the restoration of lower limbs movements.
2.Study the lower limber somatosensory evoked potentials in patients with delayed encephalopathy after acute carbon monoxide poisoning
Xiahong WANG ; Bo XIAO ; Renjun GU
Journal of Clinical Neurology 1988;0(02):-
Objective To evaluate the changes of the lower limber somatosensory evoked potentials (SEPs) in patients with delayed encephalopathy after acute carbon monoxide poisoning.Methods The tibial nerve SEPs were performed in 32 healthy adults and 40 patients with delayed encephalopathy after acute carbon monoxide poisoning. Wave N22, P40, N50, P60, N75 latency and N22~P40 interpeaklatencies were measured, respectively.Results 30 patients (75%) indicated abnormalities of tibial nerve SEPs. The latencies of cortical potential of wave P40 [(41.92?2.49)ms], N50 [(52.13?4.29) ms], P60 [(64.37?4.98) ms] and N75 [(80.84?4.73)ms] in patient group were longer than those in control group (all P