1.Clinical efficacy and prognostic factors analysis of radical hepatectomy of hepatocellular carcinoma in 760 patients
Xiangcheng LI ; Ke WANG ; Changxian LI ; Chenyu JIAO ; Xiaofeng WU ; Hui ZHANG ; Zhengshan WU ; Sheng HAN ; Guwei JI ; Dong WANG ; Yaodong ZHANG ; Renjie YANG ; Xinyang YANG ; Xuehao WANG
Chinese Journal of Digestive Surgery 2017;16(4):398-404
Objective To investigate the clinical efficacy and prognostic factors of radical hepatectomy of hepatocellular carcinoma (HCC).Methods The retrospective case-control study was conducted.The clinicopathological data of 760 HCC patients who were admitted to the First Affiliated Hospital of Nanjing Medical University from August 2003 to June 2015 were collected.Surgical procedures were determined according to the location,number and size of tumors and anatomical relations among vessels.Observation indicators included:(1)intra-and post-operative situations:surgical procedures,operation time,volume of intraoperative blood loss,cases of intraoperative blood transfusion,postoperative complications,duration of postoperative hospital stay and pathological examination;(2) follow-up:1-,3-,5-year overall and tumor-free survival situations;(3) prognostic factors analysis of HCC patients.Follow-up using outpatient examination and telephone interview was performed to detect patients' survival up to January 2016.Measurement data with normal distribution were represented as-x±s.The survival curve and survival rate were respectively drawn and calculated by the Kaplan-Meier method.The univariate analysis and multivariate analysis were done using the COX regression model.Results (1) Intra-and post-operative situations:all the 760 patients underwent successful operations,including 419 undergoing anatomical hepatectomy and 341 undergoing non-anatomical hepatectomy.R0 and R1 resections were respectively applied to 742 and 18 patients.Two patients were combined with portal vein resection and reconstruction and 1 was combined with resection and reconstruction of inferior vena cava.Operation time,volume of intraoperative blood loss and cases of intraoperative blood transfusion were (226± 115) minutes,(714±706) mL and 88,respectively.Fifty-five patients had postoperative complications,including 20 with abdominal effusion or abscess,16 with pleural effusion,9 with recurrent fever,8 with incisional infection,7 with intra-abdominal hemorrhage,6 with liver failure,3 with pyloric or intestinal obstruction and 2 with renal failure (some patients with multiple complications).Of the 55 patients with postoperative complications,7 with hemorrhage underwent reoperation or interventional therapy and other patients underwent conventional symptomatic treatment.Of 55 patients,5 patients died and other 50 patients were improved.Duration of postoperative hospital stay was (14±6) days.There were 457 patients with minimum margin of tumors ≤ 1.0 cm and 303 with minimum margin of tumors > 1.0 cm.(2) Followup:all the 760 patients were followed up for 1-139 months,with a median time of 25 months.The overall and tumor-free median survival times were 59 months and 31 months,respectively.The 1-,3-,5-year overall and tumor-free survival rates were 81.7%,63.4%,47.9% and 68.7%,44.9%,29.6%,respectively.(3) Prognostic factors analysis of HCC patients:results of univariate analysis showed that clinical symptoms,alpha-fetoprotein (AFP),Barcelona clinic liver cancer staging,surgical procedures,intraoperative blood transfusion,minimum margin of tumors,number and diameter of tumors,tumor capsule,tumor differentiation,vascular cancer embolus,macrovascular invasion and tumor staging of American Joint Committee on Cancer (AJCC) were related factors affecting prognosis of HCC patients after radical hepatectomy [HR =1.39,1.50,1.92,0.65,1.45,1.68,1.96,1.66,2.26,1.50,2.68,3.37,2.00,95% confidence interval (CI):1.08-1.79,1.16-1.94,1.68-2.20,0.50-0.84,1.04-2.02,1.28-2.20,1.54-2.49,1.42-1.94,1.69-3.02,1.22-1.85,1.99-3.60,2.61-4.36,1.77-2.27,P<0.05].Results of multivariate analysis showed that AFP,number and diameter of tumors,tumor differentiation and tumor staging of AJCC were independent factors affecting prognosis of HCC patients after radical hepatectomy (HR=1.61,1.62,1.31,1.40,1.78,95%CI:1.14-2.26,1.22-2.14,1.06-1.63,1.10-1.79,1.27-2.51,P < 0.05).Conclusions The anatomical and non-anatomical hepatectomies are safe and feasible for optional HCC patients,with a good long-term outcome.AFP,number and diameter of tumors,tumor differentiation and tumor staging of AJCC are independent factors affecting prognosis of HCC patients after radical hepatectomy.
2.Cerebral infarction following facial autologous fat transplantation: report of two cases
Renjie JI ; Ziqi XU ; Benyan LUO
Chinese Journal of Neurology 2018;51(10):836-838
Facial autologous fat transplantation is a common aesthetic procedure.Although this procedure is generally regarded as safe,several patients have experienced acute cerebral infarction after fat particles were incorrectly injected into the blood vessel.We report two cases of cerebral infarction following facial autologous fat transplantation:one patient suffered massive cerebral infarction due to the occlusion of internal carotid artery by fat embolus and died of stroke related complication,the other young women experienced acute ischemic stroke and ophthalmic artery embolism during this procedure and remained permanent blindness of right eye.Therefore,when a patient presents abrupt mental change,hemiplegia,blindness during autologous fat particle injection,doctors must consider the complication of cerebral infarction.
3.Progress of anesthetic strategy of endovascular treatment for acute ischemic stroke
Renjie JI ; Anli WANG ; Ziqi XU ; Benyan LUO
Chinese Journal of Neurology 2019;52(7):582-585
Currently,the ideal anesthetic approach for the endovascular treatment of acute ischemic stroke remains unknown.Most retrospective studies and meta-analysis report worse outcomes from general anesthesia than from conscious sedation during endovascular treatment.However,series of randomized controlled trials have not shown the advantages of conscious sedation.The choice of anesthetic strategy should continue to be individualized in clinical practice.In order to provide references for clinician,the advantages and disadvantages of general anesthesia and conscious sedation for the endovascular treatment of acute ischemic stroke were reviewed.
4.A clinical analysis of 32 patients with carotid web
Feng ZHOU ; Ziqi XU ; Renjie JI ; Li MA ; Daqiang KE ; Hui LIANG
Chinese Journal of Internal Medicine 2019;58(8):599-601
Carotid web is a rare risk factor of ischemic stroke.A total of 32 (0.54%) patients with carotid web were finally diagnosed in 5 943 patients who underwent carotid computerized tomography angiography (CTA) in two hospitals.Only one patient received carotid endarterectomy that pathological findings were fibrous tissue hyperplasia of vascular wall with mucinous degeneration.Stent implantation was administrated in two cases.Among 13 asymptomatic patients,the observational follow-up period was (20.9± 12.4) months without strokes.Carotid web is a rare aberration.Asymptomatic patients with carotid web are usually silent.Large sized cohort and long-term follow-up are further needed.
5. The significance of eosinophils in the correlation of upper and lower airway inflammation in patients with chronic rhinitis
Yong ZHANG ; Wei CHEN ; Junfeng JI ; Zhiyi WANG ; Minghai WU ; You CHENG ; Manjie JIANG ; Qiuping WANG ; Renjie CHEN
Chinese Journal of Otorhinolaryngology Head and Neck Surgery 2019;54(6):450-455
Objective:
To explore the predictor of lower airway inflammation among the index of nasal inflammation by investigating the expression and association of eosinophils (EOS) in the upper-lower airways and blood of patients with chronic rhinitis.
Methods:
A total of 162 patients with allergic rhinitis (AR), 117 patients with non-allergic rhinitis (NAR) and 104 controls were enrolled from June 2010 to December 2013 from General Hospital of Eastern Theater Command, People′s Liberation Army. All subjects were required detailed medical history collection and nasal resistance measurement. Skin prick test (SPT), blood total immunoglobin E (tIgE) and blood EOS, nasal lavage and induced sputum EOS, nasal provocation and bronchial provocation test (NPT, BPT), nasal and forced exhaled nitric oxide (NNO, FeNO) were performed in all patients. One-way analysis of variance was used for comparison between groups. LSD
6.Single-cell transcriptomic atlas of mouse cochlear aging.
Guoqiang SUN ; Yandong ZHENG ; Xiaolong FU ; Weiqi ZHANG ; Jie REN ; Shuai MA ; Shuhui SUN ; Xiaojuan HE ; Qiaoran WANG ; Zhejun JI ; Fang CHENG ; Kaowen YAN ; Ziyi LIU ; Juan Carlos Izpisua BELMONTE ; Jing QU ; Si WANG ; Renjie CHAI ; Guang-Hui LIU
Protein & Cell 2023;14(3):180-201
Progressive functional deterioration in the cochlea is associated with age-related hearing loss (ARHL). However, the cellular and molecular basis underlying cochlear aging remains largely unknown. Here, we established a dynamic single-cell transcriptomic landscape of mouse cochlear aging, in which we characterized aging-associated transcriptomic changes in 27 different cochlear cell types across five different time points. Overall, our analysis pinpoints loss of proteostasis and elevated apoptosis as the hallmark features of cochlear aging, highlights unexpected age-related transcriptional fluctuations in intermediate cells localized in the stria vascularis (SV) and demonstrates that upregulation of endoplasmic reticulum (ER) chaperon protein HSP90AA1 mitigates ER stress-induced damages associated with aging. Our work suggests that targeting unfolded protein response pathways may help alleviate aging-related SV atrophy and hence delay the progression of ARHL.
Mice
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Animals
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Transcriptome
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Aging/metabolism*
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Cochlea
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Stria Vascularis
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Presbycusis