Objective: To examine the relationship between self-inconsistency, alexithymia and Obsessions-Compulsions in neurotic patients and normal control.Methods: 59 patients and 54 control completed The Vancouver Obsessional Compulsive Inventory (VOCI), Self Consistency and Congruence Scale (SCCS), Toronto alexithymia scale (TAS-26), Self-Rating Anxiety Scale (SAS) and Self-Rating Depression Scale (SDS). Results: 1) The difference of VOCI total score among patients with obsessive-compulsive disorder (OCD), anxiety/depression (A/D), and control was significant(111.2?36.0、57.0?33.0、39.4?22.5,F=35.46,P

Objective: To compare sleep condition and mental ac tivity among short sleeper, insomniacs and normal sleeper Method: Subjects were grouped as normal sleeper, short sleeper (according to ICSD cri teria) and insomniacs All of them were measured with MMPI, self-made questionn a ire on emotion at bedtime Psychophysiological arousal and polysomnogram over n i ght were also recorded Results: Sleep latency was longer in sh o rt sleeper than normal The total spent asleep and sleep efficiency of short sl e eper had no different from those of insomniacs The awake time, A/TSA and funct i on of daytime of short sleeper were as good as normal The result of MMPI showe d , short sleeper had lower scores in Hypochondria, Depression, Conversion Hysteri a and Psychasthenia than insomniacs, higher scores in Hypomania than insomniacs or normal control They were also less anxious than insomniacs at bedtime, had s maller correlation coefficient between daytime psychophysiological arousal and s leep condition than insomniacs had Conclusion: Short sleeper h a s longer sleep latency, but quality of their sleep, their personality and emotio n at bedtime are more close to normal sleeper

Objective: to compare clinical effect of cognitive-behavior therapy and pharmacological treatment on chronic insomnia Method:48 patients with chronic insomnia were divided into 4 groups, receiving treatments of cognitive-behavior therapy, medication, placebo,and cognitive-behavior plus medication separately All of the subjects were assessed with polysomnogram over night and sleep diary Result:the three active treatments were more effective than placebo at post-treatment assessment On the eighth day of treatments, medication group and combined group showed improvement, sleep latencies were 20 min and 27 min, sleep efficacy were 80% and 82%, total sleep time were 381 min and 356 min, which were better than the results before treatments At the end of 8 weeks, cognitive-behavior group showed improvement in the above three indexes At the end of 8 months' follow-up, cognitive-behavior group still showed better effect in sleep latency 26 min, sleep efficacy 80%, total sleep time 378 min than those of 8 weeks While the indexes of the medication group and combined group could not maintain the effect of treatment Conclusion:medication shows a short-term effect on chronic insomnia, cognitive-behavior therapy shows long-term effect

Objective:To compare the sleep behaviors and the coping styles between chronic insomniacs and normal sleepers.Methods:The self-made questionnaire of sleep behaviors (including the irrational beliefs and attitudes toward sleep, the dysfunctional sleep behaviors and anxiety on evening),the coping styles and the internal-external locus of control(I-E) score were administered to 62 chronic insomniacs and 62 normal sleeper matched by age and sex.Results:The irrational beliefs and attitudes toward sleep, the dysfunctional sleep behaviors, the anxiety on evening, and the scores of I-E and of the self-blame in coping style were higher in the chronic insomniacs than in normal controls. The scores of problem-solving of the chronic insomniacs were lower than that of the normal controls. Regression analysis indicated the irrational beliefs about sleep and the dysfunctional sleep behaviors were associated with problem-solving and I-E scores.Conclusions:Chronic insomnia group has irrational beliefs and attitudes toward sleep, they have more dysfunctional sleep behaviors and higher anxiety on evening. Their ability of problem-solving is impaired and they incline to attribute their fate to external control.

AIM To develop an HPLC method for the simultaneous content determination of ginsenosides Rb1,Rd,F4,Rg1,20 (R)-Rg3,20 (S)-Rg3,Rgs,20 (R)-Rh1,20 (S)-Rh1,Rh4,Rk1,Rk3 and notoginsenoside R1 in Shusanqi Powder (processed Notoginseng Radix et Rhizoma).METHODS The analysis of 70％ methanol extract of this drug was performed on a 35 ℃ thermostatic Agilent Zorabax-C1s column (4.6 mm ×250 mm,5 μm),with the mobile phase comprising of acetonitrile-water flowing at 1.0 mL/min in a gradient elution manner,and the detection wavelength was set at 203 nm.RESULTS Thirteen saponins showed good linear relationships within their own ranges (r =0.999 5),whose average recoveries were 90.01％-108.32％ with the RSDs of 0.62％-3.54％.CONCLUSION This sensitive and accurate method can be used for the quality control of Shusanqi Powder.

Objective The relationship was analyzed between clinic and the expression intensity of HBsAg and HBcAg with in the hepatic tissue from the serum HBeAg negative group and the positive group.Methods A total of 317 liver biopsy specimens were divided into the HBeAg negative group and the positive group,and the relationship was analyzed between the expression inten sity of HBsAg and HBcAg within the hepatic tissue and their age,gender,ALT level,serum HBV-DNA load,hepatic inflammatory activity grading and fibrosis staging in the two groups.Results Age,ALT level,hepatic inflammatory activity grading and fibrosis of the serum HBeAg negative patients were greater than those of the serum HBeAg positive patients,while their serum HBV-DNA load and the expression intensity of HBcAg within the hepatic tissue were lower than those of the serum HBeAg positive patients (P＜0.05).The expression intensity of HBsAg within the hepatic tissue between the serum HBeAg patients and the serum HBeAg positive patients was not significantly different,and it was not correlated with age,ALT level,hepatic inflammatory grading and fi brosis staging (P＞0.05).After the serum HBeAg turned negative,the expression intensity of HBcAg within the hepatic tissue was decreased (P=0.00,t=12 349.0),and it became positively correlated with the serum HBV DNA load(P=0.007,r=0.251) and its negative correlation with the hepatic inflammatory activity and fibrosis was weakened.Conclusion After the serum HBeAg turned negative,other antigenic components of HBV may still maintain the adequately active immune status within the hepatic tis sue of organisms.After the serum HBeAg turned negative,the expression intensity of HBcAg within the hepatic tissue was de creased and became positively correlated with the serum HBV DNA,while its negative correlation with the hepatic inflammatory activity grade and fibrosis stagings was weakened.

Objective To analyse the relationship between catechol-O-methyltransferase (COMT) activity and affective disorders, and explore the biological mechanism of the etiology of affective disorders.Methods The activities of erythrocytes COMT from 112 affective disorders and 120 normal control were measured with high performance liquid chromatography, all examined data were tested by SPSS 11.0v.Results COMT activity frequency distribution of patients group and control group are at the range of 2～23nmol/ml RBC/hr and 7～28nmol/ml RBC/hr respectively. The average activity of COMT in patients group and control group were (11.0±3.8) nmol/ml RBC/hr and (16.1±4.3) nmol/ml RBC/hr representatively. COMT activity in male and female patient were (11.2±3.7) nmol/ml RBC/hr and (10.6± 4.0) nmol/ml RBC/hr., male and female in control group were (16.5 ±4.6) nmol/ml RBC/hr and (15.4±3.9) nmol/ml RBC/hr, there were significant difference between patients group and control group and also between male and female (P <0.001).conclusion The activity of erythrocytes COMT in affective disorders is lower than normal population and suggested that the lower COMT activity of erythrocytes is associated with affective disorders.