Objective To investigate the therapeutic methods and curative effect of combined interven-tional therapy on hepatic metastasis from colorectal cancer. Methods Hepatic artery angiography and port-calheter-system( PCS) were undertaken in 35 cases of liver metastasis from colorectal cancers. Therapeutic measare were divided into transcatheter arterial infusion(TAl) in 10 cases and transcatheter arterial emboliza-tion(TAE) in 25 cases according to their angiographic features. Drugs included oxalic acid platinum, CPT11 , MMC and 5-Fu + CF. Laser ablation under the CT guidance was taken after 2-3 courses of treatment, including 9 cases of ethanol ablation besides laser ablation. The curative effects were determined after laser ablation by checking with CT and CEA one month later. Results The lesions shrank in 17 cases, while 13 remained the same and enlarged in other 5 after 2-3 courses of TAE or TAI. CEA reduced in 6 cases, with no change in other 5 and increas in another 3 among the 14 positive CEA cases. CT scan showed spotty gasification in 29 cases and whole gasification in 6 after additional ablation treatment. Among them, the foci dwindled in 8 cases treated by solely laser ablation, with no change in 5 and increase in 7. The foci dwindled in 5 cases, 2 remainal the same and increase in 2 of 9 cases treated by the combination of laser ablation and percutaneous ethanol injection (PEI). Among 8 unchanged or increased CEA cases after TAE or TAI, showed decrease in 3 cases, other 4 remained the same and another increased after ablation. Conclusions 1. The blood supply of hepatic metastastic foci from coloreclal cancer is mainly fed by hepatic artery and subselective transcatheter angiography showed tumor stain clearly. 2. By means of PCS and TAI or TAE, using oxalic acid platinum, CPT11 and 5-Fu regular chemical therapy provided a better curative effect for metastasis. But 3. TAI or TAE can not eliminate all foci laser combining with ethanol ablation would be the effective complement.

Objective To investigate the drug resistant mechanism and the genetic homology of Acineto-bacter baumannii(A.ba)isolated from blood in the patients with bloodstream infection so as to provide a basis for the prevention and treatment of multi-drug resistant A.ba infection.Methods The different sites of sam-ples from the inpatients with bloodstream infection caused by A.ba were collected from January 2015 to June 2016.A total of 38 strains of A.Ba were isolated.The drug susceptibility test of all bacterial strains was per-formed according to the uniform operating specification.The carbapenemase gene was amplified by PCR and its products were analyzed by agarose gel electrophoresis.The homology study was performed by using multi-locus sequence typing(MLST)and eBURST analysis software.Results All 38 strains of A.ba were multi-drug-resistant.And in all of them,OXA-23-like and OXA-51-like gene,and ISAbal sequence were detected. OXA-23-like gene was associated with ISAbal sequence;the MLST typing showed that 38 A.ba strains mainly included the type ST195(55.3%),STn-2(15.8%)and STn-3(10.5%).The eBURST analysis indicated that the main prevalent clones were CC92,accounting for 86.8%.Conclusion Multi-drug resistant A.ba carries the same drug-resistant gene and its strain has higher genetic homology,indicating that the clone spread ex-ists,w hich provides a molecular biological basis for reducing the risks of A.ba related bloodstream infection in hospital.

Objective To investigate the clinical characteristics and the experience of multi-disciplinary team (MDT) on recurrence of primary hyperoxaluria (PH) type I after renal transplantation. Methods One case presenting with unexplained rapid decline of renal allograft function after allogeneic renal transplantation was discussed by MDT. The role of MDT in diagnosing rare hereditary diseases and improving the long-term survival of renal transplant recipients was summarized. Results After MDT consultation, the patient was diagnosed with recurrence of PH type I. Routine immunosuppressive regimen was initiated after the exclusion of rejection. The patient was instructed to drink a large quantity of water, and given with high-quality protein and low-phosphorus diet, vitamin B6, calcium and other conservative therapies to actively prevent and treat postoperative complications. The deterioration of renal graft function was delayed. Nevertheless, regular hemodialysis was resumed at 5 months after renal transplantation until the submission date of this manuscript. Conclusions Recurrence of PH type I after renal transplantation is relatively rare. The main clinical manifestations are recurrent kidney stones and decreased renal function with multiple complications and poor prognosis. The condition of the patient is consulted by MDT for confirming the diagnosis, determining the optimal treatment scheme, delaying the progression and improving the clinical prognosis.