No abstract available.
Humans ; Renal Insufficiency, Chronic*

No abstract available.
Renal Insufficiency, Chronic*

No abstract available.
Renal Insufficiency, Chronic*

No abstract available.
Renal Insufficiency, Chronic*

No abstract available.
Renal Insufficiency, Chronic*

No abstract available.
Renal Insufficiency, Chronic

No abstract available.
Hyperuricemia ; Renal Insufficiency, Chronic

Background: Chronic kidney disease (CKD) is a major health concern worldwide. There are limited studies which look into the actual knowledge level of CKD among the general population both locally and internationally. This study aims to assess the knowledge level of CKD among patients in a secondary hospital in Malaysia. Methods: Consecutive sampling of patients attending the Medical Outpatient Clinic was performed in this crosssectional study. Respondents were given self-administered questionnaires which contain questions on demographic characteristics and knowledge on CKD. Results: Out of 300 respondents, 78.6% (n=236) of the respondents completed the questionnaire. Majority of respondents (73.7%, n=174) scored less than 4 out of 7 marks on knowledge on CKD. Respondents who were younger, males, having higher education status, professionals/executives and earned higher monthly income were more likely to have a higher mean knowledge score of CKD. Respondents who have heard of CKD were also significantly associated with higher mean knowledge score of CKD. Conclusion: The study findings suggest that our Malaysian population is still inadequately informed on CKD, especially those who are at risk of developing CKD and its complications, and also among those of the lower socioeconomic group. In order for successful primary and secondary prevention of CKD, more importance should be placed on increasing awareness on CKD among these atrisk groups.
Renal Insufficiency, Chronic

No abstract available.
Korea ; Renal Insufficiency, Chronic

Background: Vascular calcification is an important non-conventional for cardiovascular disease (CVD) in chronic kidney disease (CKD) patients with chronic hemodialysis (HD). Abdominal aortic calcification (AAC) is reported as an independent predictor for cardiovascular morbidity and mortality. Bone-specific Alkali Phosphatase (bALP) and Alkali Phosphatase (ALP) enzymes are produced and released when changes or disorders of bone and mineral metabolism occur. Given biomarker studies such as bALP and ALP which are more often associated with patient mortality, more research will be needed to assess whether these bALP and ALP biomarkers have a linear distribution of relationships with vascular calcification. Objective: This study aimed to evaluate the serum biomarker to predict calcification and further can be one of diagnosis modality of calcification in hemodialysis patients. Methods: A total of 75 chronic HD CKD patients were included in the study. bALP and ALP serum levels were measured with ELISA, as well as AAC measured by lateral abdominal radiographs (X-Ray). Results: bALP and ALP are positively correlated with AAC scores (p value <0.001 and 0.045). Multivariate logistic regression analysis shows that history of diabetes, bALP levels, and parathyroid hormone (PTH) levels are independent risk factors for AAC in chronic HD CKD patients. Receiver Operating Characteristic (ROC) shows the area under the curve (AUC) of bALP and ALP for AAC prediction are 0.882 (95% CI: 0.801-0.962; p value: <0.001) and 0.634 (95% CI: 0.509-0.760; p value: 0.045). Conclusion ALP and especially bALP serum correlate closely with vascular calcification in chronic HD CKD patients accompanied by a superior diagnostic value of bALP biomarkers when compared to ALP.
Renal Insufficiency, Chronic