Objective To investigate the efficacy of low dose thalidomide combined with chemotherapy in treatment of multiple myeloma(MM)and the clinical curative effect of the treatment method.Methods From June 2010 to June 2012,80 patients were diagnosed with multiple myeloma as the research object in Traditional Chinese Medicine Hospital of Haining,randomly divided into control group and observation group,with 40 cases in each group.The control group adopted conventional chemotherapy,the observation group were given low dose thalidomide combined with conventional chemotherapy.The clinical effect and adverse drug reactions were compared. Results The total effective rate of observation group (87.5%)was significantly higher than that of control group(65.0%)(P<0.05).The adverse reactions were 87.5%(35/40)in observation group and 100.0%(40/40)in control group,there was no significant difference between the two groups.The mean progression-free survival(PFS)and overall survival(OS)in observation group(5.5 ±1.2 months;1 1.5 ±2.4 months)were higher than those in control group(3.7 ±0.8 months;8.5 ±1.3 months)(P<0.05 ). Conclusion Low dose thalidomide combined with conventional chemotherapy in the treatment of multiple myeloma can improve clinical effect and decrease recurrence rate,with high safety and less adverse reactions.

Radiation nephropathy refers to the damage of renal parenchyma and blood vessel caused by sufficient exposure to ionizing radiation.The clinical presentation includes proteinuria,hematuria,anemia,hypertension,and azotemia.Histological features include capillary loop thickening,mesangiolysis,formation of the double contours,subendothelial swelling,tubular atrophy,and tubulointerstitial fibrosis.Similar changes are seen in a variety of experimental animal models.The pathogenesis of radiation nephropathy remained unclear.It is reported that radiation-induced changes in kidney cell phenotype,renin angiotensin system(RAS) and oxidative stress is clearly involved.Multiple experimental studies have shown that antagonism of the RAS is beneficial,even when not initiated until weeks after irradiation.Recent findings suggest a similar benefit in clinical radiation nephropathy.

Objective To understand the awareness status on malaria control knowledge of residents,primary and middle school students in Huai’an District,Huai’an City,so as to provide the evidences for promoting the malaria elimination process in this district. Methods Three towns in Huai’an District were selected randomly,and one village,one primary school and one junior middle school in each town were chosen as the investigation sites. The residents over 18 years old,the primary school students in Grade 4 to 6,and the junior middle students in the investigation sites were investigated by questionnaires to under?stand their awareness status on knowledge of malaria control. Results Totally 305 residents and 618 students were investigated. The awareness rate of students was 89.97%,and the rates of the junior middle school students and primary school students were 85.94%and 94.10%,respectively,the difference between them was statistically significant(P<0.01). The awareness rate of the residents was 80.98%,which was lower than that of the students(P<0.05). For the students,the awareness rate on“pre?caution of malaria”(96.74%)was the highest,while that on“drug of malaria”(68.93%)was the lowest. For the residents,the rate on“transmission route of malaria”(95.08%)was the highest,that on“4·26 is Malaria Day”(64.26%)was the lowest. Ex?pect the items of“transmission route of malaria”and“precaution of malaria”(both P>0.05),the differences of the awareness rates on all the other items between the students and residents were statistically significant (all P<0.01). Conclusions Al?though the awareness rates of malaria control knowledge in the population of Huai’an District,Huai’an City have achieved the goal of the relevant requirement,the health education on malaria control still should be strengthened,especially for the primary students,female residents and exported labor service personnel.

Objective: To investigate the association between body height and risk of cancer incidence among adult men and women in Shanghai. Methods: Baseline information on body height and other factors relevant for cancer was obtained from Women's (1996-2000) and Men's Health Studies (2002-2006) in Shanghai. Participants with missing data on body height, or those lost to follow-up in one year after the study enrollment were excluded, leaving 74 709 women and 61 161 men for analysis. There were 4 031 incident cancers for women and 2 047 for men confirmed at the end of 2009. COX regression model was used to evaluate the HR s ( hazard ratios) and 95% CI (confidence interval) between height and cancers. Results: After adjustment for some potential confounding factors including age, weight, physical activity, energy intake, occupation, income and reproductive factors (for women only), HR s and 95% CI s for cancer incidence per 1 standard deviation (6 cm for both men and women) increment in body height were 1.04 (95% CI : 1.00-1.08) for total cancers, 1.18 (95% CI : 1.05-1.33) for stomach cancer, 1.34 (95% CI : 1.06-1.70) for kidney cancer and 1.05 (95% CI : 0.99-1.12) for breast cancer in women; and 1.06 (95% CI : 1.00-1.11) for total cancers, 1.11 (95% CI : 1.00-1.25) for lung cancer, 1.34 (95% CI : 1.02-1.75) for pancreatic cancer, 1.23 (95% CI : 1.01-1.49) for rectal cancer and 0.78 (95% CI : 0.66-0.94) for prostate cancer in men. Conclusion: A possible link between body height and cancer incidence in men and women is suggested. The association between body height and cancer incidence varies by cancer type. Copyright © 2012 by TUMOR.

Objective To test the effect and safety of′cocktail′wet compression on alleviate the swelling arm after the inter‐vention through the radial artery .Methods Patients whose arm were swollen after the intervention through radial artery were di‐vided into two groups (experiment group ,47 patients vs .control group ,46 patients) .The experiment group adopt the′cocktail′wet compress plus traditional therapy (including elevate and immobile the swelling arm);the control group only use the traditional ther‐apy .The levels of pain ,swelling index and the number of the blister were compared between two groups .Results None of the limbs necrosis was observed in two groups .The level of pain(2 .62 ± 0 .86 vs .5 .46 ± 1 .02) ,swelling index (3 .3% ± 2% vs .5 .8% ± 3% ) of the arm ,and the number of blister (0 vs .4) in experiment group were lower than in the control group (P<0 .05) .Conclusion The bundle of therapy strategy which named'cocktail'wet compress can lessen the swelling of the arm induced by intervention through radial artery ;it is both safe and effective thus deserves widely application .

OBJECTIVE： To observe the effect of drug loading， medium composition， transdermal enhancer， lauryl alcohol and azone on percutaneous permeation of oxaprozin gel in vitro.METHODS： Drug permeation test was carried out by using modified Franz-type double compartment diffusion cell and isolated mice skin in vitro as transdermal barrier.RESULTS： Under the condition of an effective area of 5.77cm2， it was found that the result was stable and the reproducibility was well with drug loading more than 1.2g， the receiver solution ethanol to normal saline=7∶ 3(v∶ v);The transdermal enhancing effect of lauryl alcohol was superior to that of azone， the effect of mixed transdermal enhancer 3％ AZ＋ 10％ LA was the best.CONCLUSION： The selection of both the optimum release condition and the best penetration enhancers provided reference for oxaprozin transdermal delivery.The standardization of gel percutaneous test in vitro was discussed preliminarily.

【Objective】To determine the content and dissolution of two imported levothyroxine sodium tablets.【Method】The content of levothyroxine sodium was assayed on a Hypersil BDS C18 column with a mobile phase consisting of methanol-0.85% phosphoric acid (60∶40) at a flow rate of 1.5 mL/min and detected at 225 nm.The study on dissolution was conducted according to the method Ⅱ of dissolution apparatus in USP(23).【Results】The average content of two formulations was 107.74% and 99.72%,respectively.The value of T50,Td and m of two tablets differed significantly (P<0.01).【Conclusion】There was a significant dissolution difference between two levothyroxine sodium tablets.

Objective To develop coronary artery disease self-management scale and evaluate its reliability and validity.Methods The item pool was based on the theory of chronic disease self-management and the evidence of behavioral medical science related to coronary heart disease.Firstly,the preliminary scale was developed through specialist evaluation;then it was reviewed by 10 patients and specialists again;At last,209 patients were surveyed and based on the pilot data,a series of statistic analysis was conducted such as factor analysis,correlation analysis,etc.To deduce the items to 27 and then a comprehensive set of psychometric tests was performed on the final version.Results Psychometric tests with the application of stringent criteria confirmed the test-retest reliability(ICC=0.910),internal consistency(Cronbach's ?=0.913),criterion-related validity(r=0.271-0.573),construct validity(factor analysis confirms the hypothesis of the scale),responsiveness(t=9.011,P

The safety and effectiveness of catheter ablation in coronary sinus using radiofre-quency energy was studied in 16 dogs. Radiofrequency energy(1229?711 J) was applied between electrode catheter placed inside coronary sinus and a chest wall patch. Thirteen dogs were killed approximately half an hour after ablation and three 3 to 4 weeks. Lesion of abltion area were 3. 2?1. 8mm in length, 2. 2?1. 7mm in width and 2. 1?1. 0mm in depth. Microscopic examination showed well circumscribed area of coagultion necrosis (acute period)and fibrosis (chronic period). The coronary atery and mitral apparatus were not involved,nor was the endocadium. No arrhyth-mias except occationally atrial or ventricular premature beats were observed. No hemodynamic changes and rupture of coronary sinus occurred in any dog. Large amount of radiofrequency energy can be safely applied to the coronary sinus. The location of the lesions produced suggests that this technique may be useful for interruption of left-sided atioventricular pathways of patients.

Objective To investigate the infection situation of Pseudomonas aeruginosa (PA) in patients with the lower respira‐tory tract infection in the department of respiratory intensive care units (RICU ) in recent five years ,and to analyze the changing trend of antibacterial resistence ,in order to guide rational selection of antimicrobial agents .Methods Strains of bacteria were isola‐ted and identified from sputum specimen of patients in the department of RICU and common ward from Jul .2008 to Jul .2013 .The situations of PA infection and antibacterial resistence were analyzed ,and differences of infection rates of PA and antibacterial resis‐tence were compared between RICU and common ward .Results 517 strains of bacteria were detected from sputum specimens of patients in the department of RICU from 2008 to 2013 ,including 141 strains of PA (accounted for 27 .3% ) ,and ticarcilli/clavulanic acid(61 .0% ) was with the highest rate of resistance among 14 drugs and colistin B(9 .2% ) was with the lowest rate of resistance . 378 strains of bacterias were detected from sputum specimens of patients in common wards ,including 125 strians of PA(accounted for 33 .1% ) ,and ticarcilli/clavulanic acid(28 .0% ) was with the highest rates of resistance and colistin B (4 .0% ) was with the low‐est rate of resistance .Conclusion In recent 5 years ,PA might be one of the main pathogenic bacterias of respiratory tract infections in the depatment of RICU in this hospital ,and antibiotic resistance may increse gradually .The antibiotic resistance in the depatment of RICU may be higher than that in cionmon wards .Clinical effective measures should be taken to prevent nosocomial infection ,and rational use of antibiotics should be taken to reduce the emergence of resistant strains .