1.Research status and prospect of remyelination in multiple sclerosis based on "inflammation-tissue" homeostatic coupling.
Li-Na YANG ; Xin-Ke DU ; Li LIU ; Man-Jing LI ; Qing-Sen RAN ; Qing YANG ; Li-Dong SUN ; Yu-Jie LI ; Ying CHEN ; Xiao-Xin ZHU ; Qi LI
China Journal of Chinese Materia Medica 2023;48(1):5-12
Multiple sclerosis(MS) shows the pathological characteristics of "inflammatory injury of white matter" and "myelin repair disability" in the central nervous system(CNS). It is very essential for MS treatment and reduction of disease burden to strengthen repair, improve function, and reduce disability. Accordingly, different from the simple immunosuppression, we believe that key to strengthening remyelination and maintaining the "damage-repair" homeostasis of tissue is to change the current one-way immunosuppression strategy and achieve the "moderate pro-inflammation-effective inflammation removal" homeostasis. Traditional Chinese medicine shows huge potential in this strategy. Through literature research, this study summarized the research on remyelination, discussed the "mode-rate pro-inflammation-effective inflammation removal" homeostasis and the "damage-repair" homeostasis based on microglia, and summed up the key links in remyelination in MS. This review is expected to lay a theoretical basis for improving the function of MS patients and guide the application of traditional Chinese medicine.
Humans
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Multiple Sclerosis/pathology*
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Remyelination/physiology*
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Myelin Sheath/pathology*
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Inflammation/drug therapy*
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Homeostasis
2.Myt1L Promotes Differentiation of Oligodendrocyte Precursor Cells and is Necessary for Remyelination After Lysolecithin-Induced Demyelination.
Yanqing SHI ; Qi SHAO ; Zhenghao LI ; Ginez A GONZALEZ ; Fengfeng LU ; Dan WANG ; Yingyan PU ; Aijun HUANG ; Chao ZHAO ; Cheng HE ; Li CAO
Neuroscience Bulletin 2018;34(2):247-260
The differentiation and maturation of oligodendrocyte precursor cells (OPCs) is essential for myelination and remyelination in the CNS. The failure of OPCs to achieve terminal differentiation in demyelinating lesions often results in unsuccessful remyelination in a variety of human demyelinating diseases. However, the molecular mechanisms controlling OPC differentiation under pathological conditions remain largely unknown. Myt1L (myelin transcription factor 1-like), mainly expressed in neurons, has been associated with intellectual disability, schizophrenia, and depression. In the present study, we found that Myt1L was expressed in oligodendrocyte lineage cells during myelination and remyelination. The expression level of Myt1L in neuron/glia antigen 2-positive (NG2) OPCs was significantly higher than that in mature CC1 oligodendrocytes. In primary cultured OPCs, overexpression of Myt1L promoted, while knockdown inhibited OPC differentiation. Moreover, Myt1L was potently involved in promoting remyelination after lysolecithin-induced demyelination in vivo. ChIP assays showed that Myt1L bound to the promoter of Olig1 and transcriptionally regulated Olig1 expression. Taken together, our findings demonstrate that Myt1L is an essential regulator of OPC differentiation, thereby supporting Myt1L as a potential therapeutic target for demyelinating diseases.
Animals
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Cell Differentiation
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physiology
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Demyelinating Diseases
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chemically induced
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Lysophosphatidylcholines
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toxicity
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Mice
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Mice, Inbred C57BL
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Nerve Tissue Proteins
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metabolism
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Oligodendrocyte Precursor Cells
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cytology
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metabolism
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Oligodendroglia
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cytology
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metabolism
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Remyelination
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physiology
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Transcription Factors
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metabolism
3.Lipocalin-2-Mediated Insufficient Oligodendrocyte Progenitor Cell Remyelination for White Matter Injury After Subarachnoid Hemorrhage via SCL22A17 Receptor/Early Growth Response Protein 1 Signaling.
Qiang LI ; Xufang RU ; Yang YANG ; Hengli ZHAO ; Jie QU ; Weixiang CHEN ; Pengyu PAN ; Huaizhen RUAN ; Chaojun LI ; Yujie CHEN ; Hua FENG
Neuroscience Bulletin 2022;38(12):1457-1475
Insufficient remyelination due to impaired oligodendrocyte precursor cell (OPC) differentiation and maturation is strongly associated with irreversible white matter injury (WMI) and neurological deficits. We analyzed whole transcriptome expression to elucidate the potential role and underlying mechanism of action of lipocalin-2 (LCN2) in OPC differentiation and WMI and identified the receptor SCL22A17 and downstream transcription factor early growth response protein 1 (EGR1) as the key signals contributing to LCN2-mediated insufficient OPC remyelination. In LCN-knockdown and OPC EGR1 conditional-knockout mice, we discovered enhanced OPC differentiation in developing and injured white matter (WM); consistent with this, the specific inactivation of LCN2/SCl22A17/EGR1 signaling promoted remyelination and neurological recovery in both atypical, acute WMI due to subarachnoid hemorrhage and typical, chronic WMI due to multiple sclerosis. This potentially represents a novel strategy to enhance differentiation and remyelination in patients with white matter injury.
Mice
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Animals
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Remyelination/physiology*
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Oligodendrocyte Precursor Cells/metabolism*
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White Matter
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Subarachnoid Hemorrhage/metabolism*
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Lipocalin-2/metabolism*
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Early Growth Response Protein 1/metabolism*
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Oligodendroglia/metabolism*
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Mice, Knockout
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Cell Differentiation/physiology*
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Brain Injuries/metabolism*