1. Comparison of screening performance between primary high-risk HPV screening and high-risk HPV screening plus liquid-based cytology cotesting in diagnosis of cervical precancerous or cancerous lesions
Xuelian ZHAO ; Rezhake REMILA ; Shangying HU ; Li ZHANG ; Xiaoqian XU ; Feng CHEN ; Qinjing PAN ; Xun ZHANG ; Fanghui ZHAO
Chinese Journal of Preventive Medicine 2018;52(5):469-474
Objective:
To evaluate and compare the screening performance of primary high-risk HPV(HR-HPV) screening and HR-HPV screening plus liquid-based cytology (LBC) cotesting in diagnosis of cervical cancer and precancerous lesions (CIN2+).
Methods:
We pooled 17 population-based cross-sectional studies which were conducted across China from 1999 to 2008. After obtaining informed consent, all women received liquid-based cytology(LBC)testing, HR-HPV DNA testing. Totally 28 777 women with complete LBC, HPV and biopsy results were included in the final analysis. Screening performance of primary HR-HPV DNA screening and HPV screening plus LBC co-testing in diagnosis of CIN2+ were calculated and compared among different age groups.
Results:
Among the whole population, the detection rates of primary HR-HPV screening and HR-HPV screening plus LBC co-testing are 3.05% (879 CIN2+) and 3.13%(900 CIN2+), respectively. The sensitivity were 96.4% and 98.7% (χ2=19.00,
2. Role of HPV viral loads in random biopsy under normal colposcopy
Xiaoqian XU ; Li ZHANG ; Shangying HU ; Remila REZHAKE ; Xuelian ZHAO ; Feng CHEN ; Xun ZHANG ; Qinjing PAN ; Youlin QIAO ; Fanghui ZHAO
Chinese Journal of Preventive Medicine 2018;52(5):475-479
Objective:
To explore the role of HPV viral loads in random biopsy under normal colposcopy.
Methods:
908 atypical squamous cells of undetermined significance (ASC-US) and HPV positive women, recruited in cluster sampling in 9 provinces including 5 urban areas and 9 rural areas in China from 1999 to 2008 and meeting the inclusion and exclusion criteria were included in this analysis. According to relative light units/cutoff (RLU/CO) value, subjects were stratified as low (286 cases), intermediate (311 cases) and high (311 cases) viral load groups. Risks of cervical intraepithelial neoplasia grade 3 or worse (CIN3+) among different viral load groups were compared with linear trend Chi-square test.
Results:
Detection rate of CIN3+ in low, intermediate and high viral load groups were 2.1% (6 cases), 2.6% (8 cases) and 6.8% (21 cases) (Chi-square test for trend χ2=8.91,
3.Human papillomavirus distribution and cervical cancer epidemiological characteristics in rural population of Xinjiang, China.
Yan WANG ; Ying-Bin CAI ; William JAMES ; Jian-Lin ZHOU ; Remila REZHAKE ; Qian ZHANG
Chinese Medical Journal 2021;134(15):1838-1844
BACKGROUND:
Cervical cancer remains a major public health issue for the Uyghur women and other women living mainly in rural areas of Xinjiang. This study aims to investigate the distribution of human papillomavirus (HPV) infection and cervical cancer in rural areas of Xinjiang, China.
METHODS:
Cervical cancer screening was performed on rural women aged 35 to 64 years from Xinjiang, China in 2017 through gynecological examination, vaginal discharge smear microscopy, cytology, and HPV testing. If necessary, colposcopy and biopsy were performed on women with suspicious or abnormal screening results.
RESULTS:
Of the 216,754 women screened, 15,518 received HPV testing. The HPV-positive rate was 6.75% (1047/15,518). Compared with the age 35-44 years group, the odds ratios (ORs) of HPV positivity in the age 45-54 years and 55-64 years groups were 1.18 (95% confidence interval [CI]: 1.02-1.37) and 1.84 (95% CI: 1.53-2.21), respectively. Compared with women with primary or lower education level, the ORs for HPV infection rates of women with high school and college education or above were 1.37 (95% CI: 1.09-1.72) and 1.62 (95% CI: 1.23-2.12), respectively. Uyghur women were less likely to have HPV infection than Han women, with an OR (95% CI) of 0.78 (0.61-0.99). The most prevalent HPV types among Xinjiang women were HPV 16 (24.00%), HPV 33 (12.70%), and HPV 52 (11.80%). The detection rate of cervical intraepithelial neoplasia (CIN)2+ was 0.14% and the early diagnosis rate of cervical cancer was 85.91%. The detection rates of vaginitis and cervicitis were 19.28% and 21.32%, respectively.
CONCLUSIONS
The HPV infection rate in Xinjiang is low, but the detection rate of cervical cancer and precancerous lesions is higher than the national average level. Cervical cancer is a prominent public health problem in Xinjiang, especially in southern Xinjiang.
Adult
;
Alphapapillomavirus
;
China/epidemiology*
;
Early Detection of Cancer
;
Female
;
Humans
;
Middle Aged
;
Papillomaviridae/genetics*
;
Papillomavirus Infections/epidemiology*
;
Rural Population
;
Uterine Cervical Neoplasms/epidemiology*
4. Comparison of high-risk human papillomavirus infection rate and genotype distribution between Han and Mongolian women
Shuang ZHAO ; Xuelian ZHAO ; Shangying HU ; Yan WANG ; Rezhake REMILA ; Xiaoqian XU ; Xianzhi DUAN ; Feng CHEN ; Xun ZHANG ; Fanghui ZHAO
Chinese Journal of Epidemiology 2019;40(11):1439-1444
Objective:
To understand the infection rate and genotype distribution of high risk-human papillomavirus (HR-HPV) and the detection rate of different grades of cervical lesions in Han and Mongolian women in China and provide evidence for the development of screening and vaccination strategies for the prevention and control of cervical cancer in different ethnic groups.
Methods:
In June 2017, a multicenter, population-based study for cervical cancer screening in low-resource settings in China was conducted in three rural areas: Xiangyuan and Yangcheng counties in Shanxi province, and Etuoke county in Inner Mongolia Autonomous Region. A total of 9 517 women aged 30-65 years were included in the study, and two cervical and vaginal secretion samples were collected from them for HPV and PCR-based HPV DNA tests. The positive samples in any of two tests were used for PCR-based HPV genotyping test by using Sansure-pioneered One-Step Fast Release technology. Women with positive results in any the HPV tests were referred for colposcopy and punch biopsy was given if cervical intraepithelial neoplasia lesion (low-grade lesion or worse) was suspected in colposcopy evaluation. Endocervical curettage was performed if women had an unsatisfactory colposcopy exam (the squamocolumnar junction was not completely visible). Pathological detection result was used as the golden standard of diagnosis.
Results:
HR-HPV infection rates in Han and Mongolian women were 21.83