Mindfulness is a process in which all thoughts, feelings, sensations, and all phenomena that happen to me are uncritically recognized as they are, so that they are eventually accepted and released without identifying or automatically responding to them. The clinical effects of mindfulness-based therapy have already been demonstrated in several studies. However, consistent results have not been reported for the mechanism of mindfulness-based treatment. Thus, this review aimed to describe a systematic review of the literature and research on the mechanisms of mindfulness-based interventions. Experienced meditators showed a physiological change in a ‘wakeful hypometabolic state’ during mindfulness meditation. In mindfulness meditation, it is known that certain areas other than brain activation during relaxation are additionally activated, particularly activation of fronto-limbic and fronto-parietal neural networks. The psychological mechanisms include meta-cognitive awareness, emotion regulation, reduction of automatic and self-referential thinking, concentration control, self-compassion, improvement of value clarification and self-regulation, exposure, extinction, and reconsolidation. Of the brain regions with changes in activity associated with mindfulness meditation, prefrontal cortex, the default mode network including cortical midline structures were associated with emotion regulation, concentration control, and reduction of automatic and self-referential thinking. In addition, brain regions associated with mindfulness meditation have been reported in the hippocampus, amygdala, and medical frontal cortices associated with memory reconsolidation and fear extinction. Thus, mindfulness-based interventions have a psychological and neurobiological effect with a special mechanism different from other psychological interventions, so that mindfulness based intervention can be an effective therapeutic intervention with a different mechanism from other psychological techniques.
Amygdala ; Brain ; Frontal Lobe ; Hippocampus ; Meditation ; Memory ; Mindfulness ; Prefrontal Cortex ; Psychological Techniques ; Relaxation ; Self-Control ; Sensation ; Thinking

The present study was designed to evaluate the possible beneficial effects of biofeedback-assisted relaxation to pharmacotherapy on blood pressure and heart rate in patients with essential hypertension. Twenty patients with essential hypertension and without any complications or end-organ damage participated in the study. All the patients were using anti-hypertensive drugs. The study protocol consisted of an interview, 10 days baseline, 10 biofeedback-assisted relaxation sessions and a 10-day post-treatment period. Interview blood pressure (BP) and heart rate (HR) measurements, baseline mean values of systolic blood pressure (SBP), diastolic blood pressure (DBP) and HR recorded during the 1st, 10th and 20th minutes of each session and the post-treatment mean values were evaluated. Significant differences were found between the mean values of SBP, DBP and HR after the whole treatment protocol (Wilcoxon signed-ranks test). The mean values of SBP, DBP and HR measurements recorded during the 1st, 10th and 20th minutes of the biofeedback-assisted relaxation sessions, which were evaluated by repeated measures of ANOVA on ranks test, showed a significant decrease only for the 10th minute values at the end of the whole treatment program. Despite a short follow-up, it was suggested that these results were encouraging considering the fact that once the patients are thoroughly instructed in home practice of relaxation and encouraged to develop their own strategies for relaxation, the long term outcome may also be promising.
Adult ; Aged ; Biofeedback (Psychology)* ; Blood Pressure/drug effects* ; Female ; Follow-Up Studies ; Heart Rate/drug effects* ; Human ; Hypertension/therapy* ; Male ; Middle Age ; Relaxation Techniques*

A heart simulator, UT-Heart, is a finite element model of the human heart that can reproduce all the fundamental activities of the working heart, including propagation of excitation, contraction, and relaxation and generation of blood pressure and blood flow, based on the molecular aspects of the cardiac electrophysiology and excitation-contraction coupling. In this paper, we present a brief review of the practical use of UT-Heart. As an example, we focus on its application for predicting the effect of cardiac resynchronization therapy (CRT) and evaluating the proarrhythmic risk of drugs. Patient-specific, multiscale heart simulation successfully predicted the response to CRT by reproducing the complex pathophysiology of the heart. A proarrhythmic risk assessment system combining in vitro channel assays and in silico simulation of cardiac electrophysiology using UT-Heart successfully predicted druginduced arrhythmogenic risk. The assessment system was found to be reliable and efficient. We also developed a comprehensive hazard map on the various combinations of ion channel inhibitors. This in silico electrocardiogram database (now freely available at http://ut-heart.com/) can facilitate proarrhythmic risk assessment without the need to perform computationally expensive heart simulation. Based on these results, we conclude that the heart simulator, UT-Heart, could be a useful tool in clinical medicine and drug discovery.
Blood Pressure ; Cardiac Electrophysiology ; Cardiac Resynchronization Therapy ; Cardiotoxicity ; Clinical Medicine ; Computer Simulation ; Drug Discovery ; Drug Evaluation, Preclinical ; Electrocardiography ; Heart ; Humans ; In Vitro Techniques ; Ion Channels ; Models, Cardiovascular ; Relaxation ; Risk Assessment

AIMTo further investigate the relaxation mechanism of neferine (Nef), a bis-benzylisoquinoline alkaloid extracted (isolated) from the green seed embryo of Nelumbo nucifera Gaertn in China, on rabbit corpus cavernosum tissue in vitro.

METHODSThe effects of Nef on the concentrations of cyclic adenosine monophosphate (cAMP) and cyclic guanosine monophosphate (cGMP) in isolated and incubated rabbit corpus cavernosum tissue were recorded using 125I radioimmunoassay.

RESULTSThe basal concentration of cAMP in corpus cavernosum tissue was 5.67 +/- 0.97 pmol/mg. Nef increased the cAMP concentration in a dose-dependent manner (P < 0.05), but this effect was not inhibited by an adenylate cyclase inhibitor (cis-N-[2-phenylcyclopentyl]azacyclotridec-1-en-2-amine, MDL-12, 330A) (P > 0.05). The accumulation of cAMP induced by prostaglandin E1 (PGE1, a stimulator of cAMP production) was also augmented by Nef in a dose-dependent manner (P < 0.05). The basal concentration of cGMP in corpus cavernosum tissue is 0.44 +/- 0.09 pmol/mg. Nef did not affect this concentration of cGMP, either in the presence or in the absence of a guanyl cyclase inhibitor (1H-[1,2,4]oxadiazolo[4,3-a]quinoxalin-1-one, ODQ) (P > 0.05). Also, sodium nitroprusside (SNP, a stimulator of cGMP production)-induced cGMP production was not enhanced by Nef (P > 0.05).

CONCLUSIONNef, with its relaxation mechanism, can enhance the concentration of cAMP in rabbit corpus cavernosum tissue, probably by inhibiting phosphodiesterase activity.

Animals ; Benzylisoquinolines ; pharmacology ; therapeutic use ; Cyclic AMP ; metabolism ; Cyclic GMP ; metabolism ; Drugs, Chinese Herbal ; Erectile Dysfunction ; drug therapy ; In Vitro Techniques ; Male ; Muscle Relaxation ; drug effects ; Muscle, Smooth ; drug effects ; Nelumbo ; Penile Erection ; drug effects ; Penis ; drug effects ; metabolism ; Phytotherapy ; Plant Extracts ; Rabbits ; Radioimmunoassay ; Seeds ; Vasodilator Agents ; pharmacology ; therapeutic use

OBJECTIVES: Emotional support and a stress management program should be simultaneously provided to clients as effective preventive services for healthy behavioral change. This study was conducted to review various relaxation and meditation intervention methods and their applicability for a preventive service program. METHODS AND RESULTS: The author of this paper tried to find various relaxation and meditation programs through a literature review and program searching and to introduce them. The 'Relaxation Response' and 'Mindfulness Based Stress Reduction (MBSR)' are the most the widely used meditative programs in mainstream medical systems. Abdominal breathing, Progressive Musclular Relaxation (PMR), Relaxative Imagery, Autogenic Training (AT) and Biofeedback are other well-known techniques for relaxation and stress management. I have developed and implemented some programs using these methods. Relaxation and meditation classes for cancer patients and a meditation based stress coping workshop are examples of this program. CONCLUSIONS: Relaxation and meditation seem to be good and effective methods for primary, secondary and tertiary preventive service programs. Program development and standardization and further study are needed for more and wider use of the mind-body approach in the preventive service area of medicine.
Biofeedback, Psychology ; Humans ; *Meditation ; *Mind-Body Relations, Metaphysical ; Mind-Body Therapies ; *Preventive Health Services ; Primary Prevention ; *Relaxation Therapy ; Secondary Prevention ; Stress, Psychological/prevention & control/*therapy ; Tertiary Prevention

PURPOSE: Women who undergo gynecological surgery have moderate and severe sensation and distress of pain despite the advent of patient controlled analgesia (PCA). The purposes of this study were to describe perception of non-pharmacological therapy for postoperative pain control and examine changes of pain sensation and distress in women who had gynecological surgery. METHOD: The sample consisted of 52 women who were having gynecological surgery. Subjects who agreed to participate in the study were asked for their opinion about non-pharmacological approaches for postoperative pain control using a structured study questionnaire. Pain sensation and distress were assessed by VAS in the morning and afternoon for 2 days following the surgery. RESULT: About 50% of the subjects thought that non-pharmacological methods such as relaxation, music, massage, or meditation would be helpful for their postoperative pain control. If both pharmacological and non-pharmacological therapy were given for pain control, 96% of subjects reported it would be effective. Nurses can apply techniques of relaxation, deep breathing, meditation, and music therapy to surgical patients along with PCA. Expected sensation and distress of pain was high, but pain levels gradually decreased over time. However, subjects experienced moderate levels of pain postoperatively although they used PCA. CONCLUSION: The effect of a combined method of pharmacological and non-pharmacological approach needs to be tested if postoperative pain is to be decreased more.
Analgesia, Patient-Controlled ; Female ; Gynecologic Surgical Procedures* ; Humans ; Massage ; Meditation ; Music ; Music Therapy ; Pain, Postoperative* ; Passive Cutaneous Anaphylaxis ; Surveys and Questionnaires ; Relaxation ; Respiration ; Sensation

Mind-body medicine (MBM) is a field of medicine concerned with the ways that the mind and emotions influence the body and physical health. It may be more accurate to think of mind/body as a single entity, with the health of one part necessarily influencing that of the other. The National Institutes of Health (NIH) defines MBM techniques (MBT) as interventions that use a variety of techniques designed to facilitate the mind's capacity to affect bodily functions and symptoms. MBT offers patients with greater control in their treatment, cheaper alternatives, effective options for managing chronic conditions, and methods for maintaining wellness. Mind-body approaches include guided imagery, meditation, hypnosis, and movement therapies such as dance, tai chi, chi gong, and yoga as well as music and chanting. Such approaches are as old as traditional oriental healing systems and as widespread as seen in Chinese, Indian, and East Asians. Modern Western medicine is now beginning to give MBTs recognition in its importance as well as efficacy. This article reviews the medical literatures on the techniques that have been studied the most: relaxation therapy, meditation, hypnosis, cognitive-behavioral therapy guided imagery, and biofeedback.
Asian Continental Ancestry Group ; Biofeedback, Psychology ; Humans ; Hypnosis ; Imagery (Psychotherapy) ; Integrative Medicine ; Meditation ; Mind-Body Therapies ; Music ; National Institutes of Health (U.S.) ; Relaxation Therapy ; Singing ; Tai Ji ; Yoga

In treatment of depression, non-pharmacological treatment is as important as pharmacological treatment. However, in clinical practice in Korea, non-pharmacological treatment is not provided sufficiently and patients are not satisfied with psychiatric interviews. Accordingly, patients ask for more information from clinicians. Clinicians should be aware of the characteristics of depression in Korean patients, because the manifestations of symptoms are influenced by cultural factors. In particular, depressed patients complain about somatic symptoms more frequently than they complain about depressed mood itself. In order to establish a therapeutic relationship with depressed patients, clinicians should be aware of these characteristics of depressed patients and clinicians should also address the needs of their patients. The author introduces evidence-based self-care methods for Korean patients with depression. St. John's wort, acupuncture, air ionization, light therapy, massage bibliotherapy, exercise, meditation, relaxation, and yoga can be helpful for overcoming depression. Among them, the Clinical Research Center for Depression, an organization supported by the Ministry of Health and Welfare, has recommended several non-pharmacological treatments for depression. First of all, exercise, such as walking more than 30 min. everyday, is strongly recommended. Other recommendations include bibliotherapy, interpersonal psychotherapy, cognitive behavioral therapy, and short-term psychodynamic supportive psychotherapy. For the nationwide management of depression, social bias against the treatment of depression should be reduced and non-pharmacological treatment for depression should be encouraged.
Acupuncture ; Air Ionization ; Bias (Epidemiology) ; Bibliotherapy ; Cognitive Therapy ; Depression ; Humans ; Hypericum ; Korea ; Massage ; Meditation ; Phototherapy ; Psychotherapy ; Relaxation ; Self Care ; Walking ; Yoga

PURPOSE: Complementary and alternative therapies(CAT) are defined as those treatments and healthcare practices not taught widely in medical schools, not generally used in hospitals, and not usually reimbursed by health care insurance. Recently, CAT have become increasingly popular with health care consumers and health care professionals. This study investigated nurses' perceptions and experiences with CAT. METHOD: 124 nurses who were working in university hospitals in Seoul and Inchon were randomly selected as participants for this study. They answered open and closed questionnaires on their perceptions and experiences with CAT. RESULTS: Most of the subjects recognized the existence of CAT (86.3%), and expected a treatment effect from CAT when it is combined with conventional therapy (84.7%). Nurses accepted CAT positively as complement for conventional therapy and useful modalities of psychological support when its effects have been proven scientifically. Forty nurses (32.3%) had learned CAT including soojichim, aroma therapy, relaxation, meditation, music therapy, massage, and acupressure. Eight nurses (6.5%) used CAT with patients including soojichim, hand massage, relaxation, and music therapy. CONCLUSION: In spite of the nurses' positive perceptions of CAT, the nurses' professional experiences were quite limited. Nurses need authorized training programs and continuing education opportunities in CAT. This would increase their ability to use CAT. But to improve scientific knowledge more evidence based research is.
Acupressure ; Animals ; Aromatherapy ; Cats ; Complement System Proteins ; Complementary Therapies* ; Delivery of Health Care ; Education ; Education, Continuing ; Hand ; Hospitals, University ; Humans ; Incheon ; Insurance ; Massage ; Meditation ; Music Therapy ; Surveys and Questionnaires ; Relaxation ; Schools, Medical ; Seoul

Myotonic dystrophy is a muscular disorder characterized by muscle weakness and myotonia. Myotonia manifests with abnormally slow relaxation after strong voluntary contraction of the muscles. In our previous study we reported that quinine sulfate provided therapeutic benefit to myotonia and a home exercise program based on muscle strengthening exercises improved muscle strength. The purpose of this study was to determine the effect of a multi-therapeutic program in patients with myotonic dystrophy. For six months, seven patients with myotonic dystrophy received heat therapy, were given psychologic intervention using relaxation techniques, were trained at home, and were given quinine sulfate. The changes in muscle strength and relaxation time between the post-six-months home exercise program combined with quinine sulfate therapy, and the post-six months multi-therapeutic program, were assessed from the first dorsal interossei, the elbow flexors, and the knee extensors. The results were as follows: 1) The mean muscle strength of the each of the three muscles after the six months multi-therapeutic program was improved but was not significant compared with the post-six-months home exercise program combined with quinine sulfate therapy. 2) The mean relaxation time of each of the three muscles after the six months multi-therapeutic program was significantly reduced compared with the home exercise program combined with quinine sulfate therapy. In conclusion, the multi-therapeutic program undertaken in this study was the better program for the patients with myotonic dystrophy.
Adolescent ; Adult ; Female ; Heat/therapeutic use ; Human ; Male ; Middle Age ; *Muscle Relaxation ; Muscles/*physiopathology ; Myotonic Dystrophy/*physiopathology/*rehabilitation ; Relaxation Techniques ; Support, Non-U.S. Gov't ; Time Factors