Purpose: To investigate the job satisfaction, burnout, and related factors associated with palliative care-certified nurses. Methods: In 2005, we performed a mail-based questionnaire survey on palliative care-certified nurses was performed using job-satisfaction and Burnout Inventory. Related factors such as working place and clinical experience were also asked. A multivariate logistic regression analysis was employed to investigate relationship between burnout and the factors. Results: Of the 171 questionnaires delivered, 137 were returned (81.1%). The means of the job satisfaction subscales were as follows, professional status: 32.6±6.5, interaction: 26.4±6.7, autonomy: 17.5±5.2, doctor-nurse relationship: 8.6±3.6, administration: 28.5±8.5, pay: 24.0±7.8, task requirement: 13.2±5.4, and mean total, 150.6±29.8. Seventy palliative care-certified nurses (51%) showed signs of burnout. On the basis of multivariate logistic regression analysis, 9 factors, including those related to respondents working in cancer hospitals (odds ratio : 34.67, 95% confidence interval : 2.90-414.29) were observed to be associated with burnout. Conclusion: In order to facilitate the activities of palliative care-certified nurses, it might be useful to provide them with workplace-specific training and support. Palliat Care Res 2010; 5(1): 127-136