BACKGROUND: Splenic Actinomycosis is a rare entity which usually presents as a difficult diagnostic case. It is a chronic granulomatous infectious disease, caused by Actinomyces which is commonly associated with history of abdominal surgery and manipulation. Majority of cases would present as an enlarging abdominal mass often mimicking malignant tumors.
CASE PRESENTATION: This paper presents a rare case of splenic actinomycosis in a 24-year-old Filipino female presenting as multiple splenic abscesses leading to gradual progressive ascites initially thought to be due to a malignant lymphoma. On physical examination, massive ascites and splenomegaly were the only abnormality appreciated. Initial radiologic imaging (x-ray, ultrasound, CT scan) revealed presence of multiple splenic nodules associated with extensive mediastinal and retroperitoneal lymphadenopathy as well as peritoneal extension/carcinomatosis (Figure 1 and 2). Splenic biopsy revealed presence of actinomyces (Figure 3).
TREATMENT AND OUTCOME: Patient was started on amoxicillin 2.0 g per day for 24 months which led to a significant resolution of her massive ascites. Subsequent abdominal ultrasound showed gradual reduction in the hepatic and splenic size with resolution of splenic foci. Patient is currently on frequent follow-up.
CONCLUSION: Splenic actinomycosis although extremely rare should be included as a differential diagnosis when presented with an unusual splenic mass or abscess on CT scan. Majority would mimic different forms of malignancy hence early histologic biopsy is usually needed to prevent unnecessary extensive and invasive surgical procedures. Radiologic and biochemical test are usually non-specific and not helpful with the establishment of the diagnosis. Although surgery remains to be the cornerstone for its management, prolonged antibiotic therapy might show promising results due to intensive closer follow up and accessibility to monitoring modalities for treatment response.

Human ; Female ; Adult ; Actinomyces ; Splenomegaly ; Amoxicillin ; Splenic Diseases ; Abscess ; Ascites ; Actinomycosis ; Lymphoma ; Neoplasms ; Anti-bacterial Agents ; Lymphadenopathy

The hepatic repair complex in the setting of cirrhosis has received increasing attention, as it implies the regression of cirrhosis, which was traditionally taken to be an irreversible state. In this brief review, the patterns of fibrosis, the existing staging systems for chronic liver disease and the histopathological features of cirrhosis regression are discussed.
Fibrosis* ; Liver Cirrhosis* ; Liver Diseases ; Liver*

Mesenchymal tumors in the liver, whether primary or metastatic, are rare. Meningeal hemangiopericytoma (HPC) is characteristically associated with delayed metastasis and the liver is one of the most common sites. Despite its consistent histological features, a pathological diagnosis of HPC in the liver is sometimes not straightforward due to its rarity and usually remote medical history of the primary meningeal tumor. In this report, the clinicopathological features of 5 cases of metastatic HPC to the liver were reviewed and described.
Adult ; Female ; Hemangiopericytoma/*pathology ; Humans ; Liver/pathology ; Liver Neoplasms/*pathology/secondary ; Male ; Meningeal Neoplasms/*pathology ; Middle Aged

Non-alcoholic fatty liver disease (NAFLD) is a spectrum of diseases characterized by fatty accumulation in hepatocytes, ranging from steatosis, non-alcoholic steatohepatitis, to cirrhosis. While histopathological evaluation of liver biopsies plays a central role in the diagnosis of NAFLD, limitations such as the problem of interobserver variability still exist and active research is underway to improve the diagnostic utility of liver biopsies. In this article, we provide a comprehensive overview of the histopathological features of NAFLD, the current grading and staging systems, and discuss the present and future roles of liver biopsies in the diagnosis and prognostication of NAFLD.