No abstract available.
Red-Cell Aplasia, Pure*

No abstract available.
Red-Cell Aplasia, Pure* ; Rituximab*

Humans ; Red-Cell Aplasia, Pure

Thymoma, a rare epithelial neoplasm, is the most common anterior-superior mediastinal tumour. Thymoma can occur sporadically or in association with other conditions, such as myasthenia gravis, pure red cell aplasia (PRCA), and hypogammaglobulinemia. Only 5% of thymoma cases develop PRCA; however, 10–50% of patients presenting with PRCA have an associated spindle cell type thymoma. Thymoma complicated by PRCA is associated with a poor outcome. We report the case of a 38-year-old female who presented with chest pain, and was diagnosed with an anterior mediastinal mass. A thymectomy was performed, and histopathological examination revealed mixed thymoma; two months later, the patient developed PRCA. The present case reinforces the need for clinicians to be vigilant with thymoma patients, even following thymectomy.
Erythropoiesis ; Mediastinum ; Red-Cell Aplasia, Pure ; Thymoma

Consensus ; Humans ; Red-Cell Aplasia, Pure

No abstract available.
Myelodysplastic Syndromes* ; Red-Cell Aplasia, Pure*

The authors have described a case with pure red cell aplasia (P.R.C.A.) caused by the administration of diphenylhydantoin after head injury. P.R.C.A. associated with diphenylhydantoin is very rare and easily treated with a discontinuation of diphenylhydantoin & steroids.
Craniocerebral Trauma ; Phenytoin* ; Red-Cell Aplasia, Pure* ; Steroids

Humans ; Anemia, Aplastic/genetics* ; Red-Cell Aplasia, Pure ; Chromosome Disorders

Pregnancy is normally a state of erythroid hyperplasia. Increased erythropoiesis during pregnancy is controlled by erythropoietin, which is augmented by the action of placental lactogen and inhibited by high levels of estrogen. We described a case of a patient with pure red cell aplasia during pregnancy that resolved completely in the postpartum period.
Erythropoiesis ; Erythropoietin ; Estrogens ; Humans ; Hyperplasia ; Placental Lactogen ; Postpartum Period ; Pregnancy* ; Red-Cell Aplasia, Pure*

Pure red cell aplasia (PRCA) in adults is usually idiopathic, although some underlying conditions can cause PRCA. Immunosuppressive therapy (IST) is used to treat PRCA, but IST has side effects and may fail. The anti-CD52 monoclonal antibody alemtuzumab (ALM) was recently used to successfully treat therapy-resistant PRCA. We herein report successful treatment of secondary PRCA after erythropoietin therapy using ALM and cyclosporin A (CsA) in one patient. The total dose of ALM was 60 mg over 3 days (10, 20, and 30 mg, respectively) plus CsA for at least 6 months. The patient achieved a complete response 18 months after ALM-CsA treatment and his treatment could be changed to a different erythropoietin-stimulating agent.
Adult ; Antibodies, Monoclonal, Humanized ; Cyclosporine ; Erythropoietin ; Humans ; Red-Cell Aplasia, Pure