1.The clinical and laboratory characteristics of T cell large granular lymphocyte leukemia.
Xin ZHAO ; Kang ZHOU ; Hui-Jun WANG ; Li ZHANG ; Qing-Guo LIU ; Li-Ping JING ; Hong-Qiang LI ; Dong-Lin YANG ; Yu-Lin CHU ; Feng-Kui ZHANG
Chinese Journal of Hematology 2009;30(3):179-182
OBJECTIVETo analyze the characteristics of T-cell large granular lymphocyte leukemia (T-LGLL).
METHODSRetrospectively analyze the clinical and laboratory data of 27 patients with T-LGLL diagnosed between 1999 and 2007 in our hospital.
RESULTSThe median age at diagnosis was 48 years. All patients were symptomatic, mainly complaining of fatigue. Of the 27 patients, 14 (51.9%) had splenomegaly, and 4(14.8%) hepatomegaly. Rheumatoid arthritis was not present in any patients. The most frequent hematological abnormality was anemia (24 patients, 88.9%) with a median Hb level of 57.5 g/L. Pure red cell aplasia was found in 18 patients (66.67%). The median WBC count was 4.24 x 10(9)/L and 19 cases were neutropenia (ANC < 1.5 x 10(9)/L). The median LGL count in peripheral blood was 1.45 x 10(9)/L and most of them (77.8%) were less than 2.0 x 10(9)/L. Twenty-two patients (81.5%) showed the CD3+ CD8+ CD57+ CD56(-) LGL phenotype. With immunosuppressive therapy, 91.3% of patients responded and complete hematological remission rate was 65.2%.
CONCLUSIONT-LGLL mainly presented with anemia and complete hematological remission rate was 65.2%. Pure red cell aplasia was commonly associated with the disease. The patients had a good response to immunosuppressive therapy.
Adolescent ; Adult ; Aged ; Female ; Humans ; Immunophenotyping ; Immunosuppression ; Leukemia, Large Granular Lymphocytic ; complications ; diagnosis ; immunology ; Male ; Middle Aged ; Red-Cell Aplasia, Pure ; etiology ; Retrospective Studies ; Young Adult
2.Persistent Anemia in a Patient with Diffuse Large B Cell Lymphoma: Pure Red Cell Aplasia Associated with Latent Epstein-Barr Virus Infection in Bone Marrow.
Hwa Jung SUNG ; Seok Jin KIM ; Ji Hye LEE ; Goeun LEE ; Kyung A LEE ; Chul Won CHOI ; Byung Soo KIM ; Jun Suk KIM
Journal of Korean Medical Science 2007;22(Suppl):S167-S170
We report a case of pure red cell aplasia (PRCA), which was initially suspected as a result of bone marrow involvement of diffuse large B cell lymphoma. Persistent anemia without an obvious cause was observed in a 47-yr-old man diagnosed with relapsed diffuse large B cell lymphoma. The bone marrow study showed only erythroid hypoplasia without the evidence of bone marrow involvement with lymphoma cells, thus PRCA was suggested. However, parvovirus infection was excluded as a potential cause of PRCA because of negative IgM anti-parvovirus B19 antibody and negative parvovirus PCR in the serum. Latent Epstein-Barr virus (EBV) infection of bone marrow was suggested by in situ hybridization with EBV-encoded small RNA (EBER) that showed a strong positive expression in bone marrow cells. Thus, PRCA was thought to be associated with latent EBV infection in bone marrow cells. Although the finding of unexplained anemia is a possible predictor of bone marrow involvement with lymphoma cells, PRCA as a result of a viral infection including EBV should be considered in lymphoma patients. This is the first report of the occurrence of PRCA associated with latent EBV infection in a patient with non-Hodgkin's lymphoma.
Adult
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Bone Marrow/pathology
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Bone Marrow Diseases/*complications/diagnosis/pathology
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Bone Marrow Neoplasms/pathology
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Diagnosis, Differential
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Epstein-Barr Virus Infections/*complications/diagnosis
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Humans
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Lymphoma, Large B-Cell, Diffuse/*complications/pathology
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Male
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Red-Cell Aplasia, Pure/diagnosis/*etiology
3.Acquired Amegakaryocytic Thrombocytopenia after Thymectomy in a Case of Pure Red Cell Aplasia Associated with Thymoma.
Ah Ra CHO ; Young Joo CHA ; Hye Ryoun KIM ; Eun Kyung PARK ; Eun Jong CHA
The Korean Journal of Laboratory Medicine 2010;30(3):244-248
The association of thymoma with pure red cell aplasia has been well documented, but amegakaryocytic thrombocytopenia is not a recognized paraneoplastic syndrome complicating thymoma. We report a case of thymoma-complicated pure red cell aplasia and amegakaryocytic thrombocytopenia in a 73-yr-old woman. Pure red cell aplasia was diagnosed seven months after the detection of thymoma. One year after the diagnosis of pure red cell aplasia and seven months after thymectomy, bone marrow aspiration and biopsy showed an absence of megakaryocytes, marked erythroid hypoplasia with normal myeloid series. A diagnosis of amegakaryocytic thrombocytopenia and pure red cell aplasia was made. Oral steroid maintenance therapy resulted in recovery of platelet count. She has still transfusion-dependant anemia but platelet and neutrophil counts had been maintained in normal range for more than five months, until the last follow-up. We think that autoreactive T cells may induce a clinical autoimmune response even after eradication of thymoma, and aplastic anemia as a late complication following thymectomy was described in previous cases. This patient also has to be under a close observation because of the possibility to evolve into aplastic anemia.
Aged
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Bone Marrow/pathology
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Female
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Humans
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Imidazoles/therapeutic use
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Megakaryocytes/pathology
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Pregnadienetriols/therapeutic use
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Red-Cell Aplasia, Pure/complications/*diagnosis
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Thrombocytopenia/*diagnosis/drug therapy/*etiology
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Thymectomy/*adverse effects
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Thymoma/*complications/diagnosis/surgery
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Thymus Neoplasms/*complications/diagnosis/surgery
4.A case of ticlopidine induced acute cholestatic hepatitis and pure red cell aplasia.
Ji Yeon LEE ; Eun Bum PARK ; Jae Hong AHN ; Sang Jun SUH ; Young Kul JUNG ; Ji Hoon KIM ; Bong Kyung SHIN ; Jin Hyuk YANG ; Jong Eun YEON ; Kwan Soo BYUN
The Korean Journal of Hepatology 2008;14(1):102-107
Ticlopidine inhibits platelet aggregation and provides beneficial secondary prevention of cerebrovascular and coronary artery disease. Frequently reported adverse effects of ticlopidine include diarrhea, nausea, and rash. However, to our knowledge, there are only a few published reports of the simultaneous occurrence of cholestatic hepatitis and pure red cell aplasia. Here we report a patient with simultaneous severe cholestatic hepatitis and pure red cell aplasia associated with ticlopidine. Although these adverse effects are rare, periodic hematological and liver function tests are recommended after starting ticlopidine.
Acute Disease
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Cholestasis/*chemically induced/diagnosis/etiology
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Female
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Hepatitis, Toxic/*diagnosis/pathology
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Humans
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Liver Function Tests
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Middle Aged
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Platelet Aggregation Inhibitors/*adverse effects
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Red-Cell Aplasia, Pure/*chemically induced/diagnosis/pathology
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Ticlopidine/*adverse effects
5.A Case of Severe Acute Hepatitis A Complicated with Pure Red Cell Aplasia.
Pyoung Suk LIM ; In Hee KIM ; Seong Hun KIM ; Seung Ok LEE ; Sang Wook KIM
The Korean Journal of Gastroenterology 2012;60(3):177-181
Hepatitis A is typically a self-limited acute illness that does not progress to chronic hepatitis. In rare cases, acute hepatitis A can be associated with serious complications (such as fulminant hepatitis or acute kidney injury) and may result in death or liver transplantation. Pure red cell aplasia (PRCA) is a rare hematologic disorder characterized by anemia, reticulocytopenia in the blood, and isolated erythroblastopenia with normal granulopoiesis and megakaryopoiesis in the bone marrow. PRCA is a rare hematopoietic complication of acute viral hepatitis, and few cases associated with hepatitis A virus infection have been reported. Recently, we experienced a case of severe hepatitis A complicated by fulminant hepatitis and acute kidney injury followed by PRCA which showed a favorable response to oral corticosteroids.
Acute Disease
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Acute Kidney Injury/etiology
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Adult
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Anti-Inflammatory Agents/therapeutic use
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Bone Marrow/pathology
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Female
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Hepatitis A/complications/*diagnosis
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Humans
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Prednisone/therapeutic use
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Red-Cell Aplasia, Pure/complications/*diagnosis/drug therapy
6.Parvovirus B19-induced Pure Red Cell Aplasia in a Liver Transplant Recipient.
Eun Young LEE ; Yonggeun CHO ; Sang Guk LEE ; Jaewoo SONG
The Korean Journal of Laboratory Medicine 2010;30(6):591-594
Parvovirus B19 infection is known to cause chronic anemia in immunocompromised hosts, including organ transplant recipients. We report the first case of liver transplant recipient with parvovirus B19-induced pure red cell aplasia in Korea. A 57-yr-old female patient with hepatocellular carcinoma due to hepatitis C virus received a liver transplantation. Two months later, anemia developed and she received periodic red blood cell transfusions. However, chronic anemia persisted and bone marrow examination was performed 8 months after transplantation. Bone marrow aspiration smears showed markedly reduced erythroid precursors with atypical giant pronormoblasts and nuclear remnants with viral inclusions, and characteristic lantern cells were observed in biopsy sections. In addition, parvovirus B19 DNA PCR was positive. She was diagnosed as parvovirus B19-induced pure red cell aplasia and her anemia was improved following intravenous immunoglobulin therapy.
Blood Transfusion
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Bone Marrow/pathology
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Carcinoma, Hepatocellular/etiology/therapy
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DNA, Viral/analysis
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Female
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Hepatitis C/complications/diagnosis
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Humans
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Immunocompromised Host
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Immunoglobulins/therapeutic use
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Liver Neoplasms/etiology/therapy
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Liver Transplantation
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Middle Aged
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Parvoviridae Infections/complications/*diagnosis
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*Parvovirus B19, Human/genetics
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Red-Cell Aplasia, Pure/*diagnosis/therapy/virology