3.Action Mechanisms of Hormone Binding to Cell Surface Receptors: 1) G-protein Coupled Receptor Signalling as Targets for Hormone Action: (2) The Role and the Regulation of Phospolipase C.
Journal of Korean Society of Endocrinology 2000;15(3):333-341
No Abstract Available.
GTP-Binding Proteins*
;
Receptors, Cell Surface*
4.Action Mechanisms of Hormone Binding to Cell Surface Receptors: 1) G-protein Coupled Receptor Signalling as Targets for Hormone Action: (1) Adenylate Cyclase Cascade.
Journal of Korean Society of Endocrinology 2000;15(3):311-332
No Abstract Available.
Adenylyl Cyclases*
;
GTP-Binding Proteins*
;
Receptors, Cell Surface*
5.A new mutation of PTCH gene in a Chinese family with nevoid basal cell carcinoma syndrome.
Yan LÜ ; Han-guang ZHU ; Wei-min YE ; Ming-bin ZHANG ; Di HE ; Wan-tao CHEN
Chinese Medical Journal 2008;121(2):118-121
BACKGROUNDNevoid basal cell carcinoma syndrome (NBCCS) is a rare autosomal dominant disease characterized by a combination of development anomalies and a predisposition to tumour formation. Mutation of patched gene (PTCH), considered the molecular defect of NBCCS, in a Chinese NBCCS family was investigated in this study.
METHODSGenomic DNA was isolated from blood samples of all 12 members of this family. The mutated PTCH gene was screened by polymerase chain reaction amplification and direct sequencing.
RESULTSA new mutation of 3 bp (GAT deletion) was found in all seven affected members of this family. This mutation caused one aspartate deletion in the fourth transmembrane domain of the PTCH protein located within the sterol sensing domain (SSD). This deletion was not found in any unaffected members of this family nor in 200 control samples.
CONCLUSIONSOur findings suggest that one 3-bp deletion in PTCH gene was the cause of nevoid basal cell carcinoma in a Chinese family through affecting the conformation and function of PTCH protein.
Basal Cell Nevus Syndrome ; genetics ; Humans ; Mutation ; Patched Receptors ; Patched-1 Receptor ; Receptors, Cell Surface ; genetics
6.Toll-like receptor and innate immunity in phylogenesis.
Ye LIU ; Li-ping ZHU ; Wei HE
Acta Academiae Medicinae Sinicae 2002;24(4):433-436
In protection against microbes, an organism recognizes the pathogen associated molecular pattern (PAMP) on microbes by pattern recognition receptor (PRR). Toll-like receptor is called innate immunity. A family of cell membrane receptor was found in recent years that can mediate innate immune responses through the activation of a series of immune-related genes. In phylogenesis, it is highly conservative. However, its functions are getting more diversified with the complication of the immune functions of organisms.
Animals
;
Humans
;
Immunity
;
Membrane Glycoproteins
;
immunology
;
Phylogeny
;
Receptors, Cell Surface
;
immunology
;
Toll-Like Receptors
7.Sepsis and membrane receptors.
Zhao-xia DUAN ; Pei-fang ZHU ; Jian-xin JIANG
Chinese Journal of Traumatology 2005;8(1):60-64
9.Action Mechanisms of Hormone Binding to Cell Surface Receptors: 3) TGF-beta; Binding to Serine-threonine Kinase Receptors and Action Mechanisms.
Journal of Korean Society of Endocrinology 2000;15(3):353-366
No Abstract Available.
Protein-Serine-Threonine Kinases*
;
Receptors, Cell Surface*
;
Transforming Growth Factor beta*
10.Comparison of bone morphogenetic protein receptors expression in the fetal and adult skin.
Eun A HWANG ; Hoon Bum LEE ; Kwan Chul TARK
Yonsei Medical Journal 2001;42(6):581-586
Wounds on fetal skin can be repaired without leaving scars until the second trimester, but after this period, skin wounds leave scars as in adults. It's known that certain growth factors such as TGF-beta, and bFGF are present at a very low levels during wound repair in fetal skin. These low levels of growth factors minimize inflammatory response and fibroblast proliferation at the wound site, which in turn inhibit collagen synthesis, and thus, allows scarless wound healing. Recently bone morphogenetic proteins (BMPs), one of the TGF-beta superfamily members, have been studied in the wound healing process. According to several studies, BMPs are related to the differentiation and growth of epithelial and mesenchymal cells, but the precise functions of BMPs and of BMP receptors on skin wound healing have not been elucidated. In this study, we investigated the expression pattern of BMP receptors in fetal skin during the second trimester and in adult skin by immunohistochemical staining and RT-PCR. BMP receptors were detected on the suprabasal epithelial cells and in the hair follicles in adult skin, but were not defected in the fetal skin except for the hair follicles. This was confirmed by confirming mRNA levels of BMP receptors by RT-PCR in both adult and fetal skins. In conclusion, BMPs and BMP receptors seem to be related to fetal and adult wound healing, and low levels of BMPs and BMP receptors during the second trimester seem to contribute to scarless wound healing in the fetus, as is TGF-beta during the second trimester.
Fetus/metabolism
;
Human
;
Immunohistochemistry
;
Receptors, Cell Surface/*metabolism
;
Reverse Transcriptase Polymerase Chain Reaction
;
Skin/*embryology/*metabolism
Result Analysis
Print
Save
E-mail