1.Lithium Intoxication Induced by Angiotensin II Receptor Blocker/Thiazide Combination Agent.
Jung Bin KIM ; Ji Wan JANG ; Ji Hyun KIM
Journal of the Korean Neurological Association 2011;29(2):151-153
No abstract available.
Angiotensin II
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Angiotensins
;
Lithium
;
Receptors, Angiotensin
2.Hyperkalemia from preoperative non-steroidal anti-inflammatory drugs and angiotensin II receptor blockers in patients with nephropathy.
Ho Kyung SONG ; Yeon JANG ; Jin Woo NAM ; Ju Hyun YOU
Korean Journal of Anesthesiology 2011;61(6):533-534
No abstract available.
Angiotensin II
;
Angiotensin Receptor Antagonists
;
Angiotensins
;
Hyperkalemia
;
Receptors, Angiotensin
3.Renin Angiotensin System in Rabbit Corpus Cavernosum: Functional Characterization of Angiotensin II Receptors.
Jong Kwan PARK ; Young Kyung PARK ; Sung Zoo KIM ; Suhn Hee KIM ; Kyung Woo CHO
Korean Journal of Urology 1997;38(1):28-36
No abstract available.
Angiotensin I
;
Angiotensin II*
;
Angiotensins*
;
Autoradiography
;
Receptors, Angiotensin*
;
Renin*
;
Renin-Angiotensin System*
4.Renin Angiotensin System in Rabbit Corpus Cavernosum: Functional Characterization of Angiotensin II Receptors.
Jong Kwan PARK ; Young Kyung PARK ; Sung Zoo KIM ; Suhn Hee KIM ; Kyung Woo CHO
Korean Journal of Urology 1997;38(1):28-36
No abstract available.
Angiotensin I
;
Angiotensin II*
;
Angiotensins*
;
Autoradiography
;
Receptors, Angiotensin*
;
Renin*
;
Renin-Angiotensin System*
6.Effect of Valsartan on Blood Pressure and Urinary Albumin Excretion in Hypertensive Type 2 Diabetic Patients: An Open-Label, Multicenter Study.
Se Jun PARK ; Dae Jung KIM ; Hae Jin KIM ; Soo Yeon PARK ; Ji A SEO ; Nan Hee KIM ; Sung Hee CHOI ; Soo LIM ; Hak Chul JANG ; Seung Hyun KO ; Ki Ho SONG ; Yu Bae AHN ; Soo Kyoung KIM ; Yong Wook CHO ; Jun Goo KANG ; Sung Hee IHM ; Cheol Young PARK ; Sung Woo PARK ; Dong Hyun SHIN ; Yong Hyun KIM ; Kwan Woo LEE
Korean Diabetes Journal 2008;32(6):513-521
BACKGROUND: Activation of renin-angiotensin system (RAS) has been an important mechanism of microvascular and macrovascular complications in diabetic patients. It has been reported that RAS blockades reduce the development and progression of diabetic nephropathy. The aim of this study was to evaluate whether valsartan, an angiotensin II receptor blocker (ARB), reduced blood pressure and urinary albumin excretion rate (UAER) in hypertensive type 2 diabetic patients. METHOD: Three hundred forty-seven hypertensive type 2 diabetic patients who had not taken angiotensin converting enzyme inhibitors or ARB for 6 months prior to this study were enrolled. We measured blood pressure and UAER before and after 24 weeks of valsartan treatment. RESULT: Baseline mean systolic and diastolic blood pressure was 143 +/- 15 and 87 +/- 11 mmHg, respectively and the median albumin excretion rate was 27 ug/mg. Reduction in systolic and diastolic blood pressure was 16 mmHg/10 mmHg and the median UAER was 19.3 ug/mg after 24 weeks (P < 0.01, respectively). When we divided the subjects into three groups according to the UAER (normoalbuminuria, microalbuminuria and macroalbuminuria), significant changes were reported in the microalbuminuria and the macroalbuminuria groups. Thirty-eight (42%) patients with microalbuminuria improved to normoalbuminuria and twelve (41%) patients with macroalbuminuria improved to microalbuminuria. We found an association between the improvement of blood pressure and UAER (R = 0.165, P = 0.015). CONCLUSION: We concluded that valsartan reduces urinary albumin excretion and blood pressure in hypertensive type 2 diabetic patients.
Angiotensin-Converting Enzyme Inhibitors
;
Angiotensins
;
Blood Pressure
;
Diabetes Mellitus
;
Diabetic Nephropathies
;
Humans
;
Receptors, Angiotensin
;
Renin-Angiotensin System
;
Tetrazoles
;
Valine
;
Valsartan
7.Effect of Angiotensin II Receptor Blockers in Proteinuric IgA Nephropathy.
Jueng Hyeun NOH ; You Cheol HWANG ; Tae Won LEE ; Chun Gyoo IHM
Korean Journal of Nephrology 2001;20(2):277-282
Whether immunosuppressive therapy may have beneficial effects in the treatment of IgA nephropathy remains controversial. ACE inhibitor or angiotensin II receptor antagonist(AIIA) are suggested to reduce urinary protein excretion(Up) in patients with renal diseases. We therefore investigated the effects of the angiotensin II receptor antagonist losartan on the proteinuria and renal function in patients with IgA nephropathy. AIIA reduced blood pressure in patients with hypertension, but there were no significant differences statistically before and after therapy. AIIA reduced Up after 1-4 months(2.8+/-1.1 to 1.1+/-1.0g/24h, p=0.001) and 7-13 months(2.8+/-1.1 to 1.7+/-0.6g/24h, p=0.017). There were no significant changes of serum creatinine levels after AIIA treatment. Cough or angioedema were not observed during AIIA treatment. In conclusion, AIIA may be useful in the treatment of patients with IgA nephropathy and proteinuria.
Angioedema
;
Angiotensin II*
;
Angiotensin Receptor Antagonists*
;
Angiotensins*
;
Blood Pressure
;
Cough
;
Creatinine
;
Glomerulonephritis, IGA
;
Humans
;
Hypertension
;
Losartan
;
Proteinuria
;
Receptors, Angiotensin*
8.Clinical Study of Angiotensin Converting Enzyme Inhibitor and Angiotensin II Receptor Antagonist Combination Therapy in Renal Patients.
So Young LEE ; Young Sun KANG ; Sang Youp HAN ; Jong Woo YUN ; Sang Kyeng JO ; Dae Ryung CHA ; Won Yong CHO ; Hyoung Kyu KIM
Korean Journal of Nephrology 2000;19(6):1078-1085
BACKGROUND: Angiotensin-converting enzyme inhibitors(ACEi) do not decrease plasma angiotensin II levels in chronic use to the same extent as in acute use. this reincrease in angiotensin II level is explained either by a renin-mediated reactive rise in plasma angiotensin I or by non-ACE dependent angiotensin II generation. The aim of this study was to compare the additive effects of an ACEi and angiotensin II receptor antagonist(AT1a) in antiproteinuric effect, hyperkalemia, and hypotension. METHODS: 58 outpatients with chronic renal insufficiency were included and they were randomly classified into two groups : Group I(prescribed AT1a only), Group II(AT1a and ACEi combination therapy), and the changes of serum creatinine, the amount of proteinuria, the developement of hyperkalemia, and hypotension were evaluated. RESULTS: In group I, the amount of proteinuria decreased to 92.8% of initial amount at 1 month after the start of drugs. 2 of 28 patients(7.1%) developed hyperkalemia, and serum creatinine did not change (1.686+/-1.415mg/dL 1.821+/-1.301mg/dL, p=0.289). But in combination therapy group, serum creatinine level increased from baseline value of 1.466+/-0.619mg/dL to 1.800+/-0.881mg/dL(p=0.05), proteinuria did not change (101% of initial amount), and 7 of 30 patients(23.3%) developed hyperkalemia. CONCLUSION: Combination therapy seems to have no additive antiproteinuric effect, but serum creatinine and potassium levels should be closely monitered during the combination therapy.
Angiotensin I
;
Angiotensin II*
;
Angiotensins*
;
Creatinine
;
Humans
;
Hyperkalemia
;
Hypotension
;
Outpatients
;
Peptidyl-Dipeptidase A*
;
Plasma
;
Potassium
;
Proteinuria
;
Receptors, Angiotensin*
;
Renal Insufficiency, Chronic
9.Renoprotective Effect of the Combined Use of Steroid and Angiotensin II Receptor Blocker in IgA Nephropathy.
Young Ki KIM ; Sang Ho LEE ; Tae Won LEE ; Myung Jae KIM ; Moon Ho YANG ; Chun Gyoo IHM
Korean Journal of Nephrology 2005;24(1):71-79
BACKGROUND: Several studies have examined the role of angiotensin II receptor blocker (ARB) or steroid treatment in decreasing proteinuria and preserving renal function in IgA nephropathy (IgAN). METHODS: We designed a prospective, randomized trial to assess the effects of combination therapy of steroid (daily high-dose for 6 months) and ARB in IgAN patients with proteinuria >or=1.0 g/d and serum creatinine (SCr)
Angiotensin II*
;
Angiotensins*
;
Creatinine
;
Glomerulonephritis, IGA*
;
Humans
;
Immunoglobulin A*
;
Prednisolone
;
Prospective Studies
;
Proteinuria
;
Receptors, Angiotensin*
10.Tissue-Specific Regulation of Angiotensinogen and Angiotensin II Receptor Genes in Two-Kidney, One Clip Hypertensive Rats.
Jong Un LEE ; Mi Ra AN ; Sang Chae NAM ; Won Jae KIM
Korean Journal of Nephrology 1999;18(4):523-529
The present study was aimed at investigating the molecular regulation of the renin- angiotensin system (RAS) in two-kidney, one clip (2K1C) hypertension. The expression of renin, angiotensinogen and angiotensin II receptor genes was determined by Northern blot analysis in rats made 2K1C hypertensive for 2 or 4 weeks. The expression of renin gene was increased in the clipped kidney and decreased in the contralateral non-clipped kidney at weeks 2 and 4. The expression of angiotensinogen gene was not significantly altered at week 2, but increased at week 4 in the clipped kidney. However, it was not significantly altered in the contralateral kidney either at week 2 or 4. Nor was the expression of angiotensinogen gene significantly altered in the liver either at week 2 or 4. On the other hand, the expression of angiotensin II receptor gene was decreased at week 2, and increased at week 4 in the clipped kidney, whereas it was not significantly changed in the contralateral kidney either at week 2 or 4. In the liver, the expression of angiotensin II receptor gene was not significantly altered at week 2, but decreased at week 4. These results suggest that the components of RAS are transcriptionally regulated in 2K1C hypertension in a manner dependent on tissues and duration of hypertension.
Angiotensin II*
;
Angiotensinogen*
;
Angiotensins*
;
Animals
;
Blotting, Northern
;
Hand
;
Hypertension
;
Kidney
;
Liver
;
Rats*
;
Receptors, Angiotensin*
;
Renin