Receptors, Adrenergic

No abstract available.
Humans* ; Receptors, Adrenergic* ; Steroids*

No abstract available
Cardiovascular System* ; Receptors, Adrenergic*

Adrenergic beta-Antagonists ; therapeutic use ; Consensus ; Humans ; Receptors, Adrenergic, beta

No abstract available.
Animals ; Cerebral Cortex* ; Imipramine* ; Rats* ; Receptors, Adrenergic*

Effects of several autonomic drugs on the responses of the isolated rabbit detrusor muscle strips to electrical stimulation were investigated. Electric stimulation of the detrusor muscle strips elicited two different responses; (a) contraction followed by relaxation in 14 cases out of 22 experiments, and (b) contraction only in 8 cases. The contraction responses to electrical stimulation were significantly reduced in the presence of either atropine or regitine, respectively The relaxation response to electrical stimulation was abolished in the presence of propranolol. Addition of norepinephrine evoked one of following three responses: (a) relaxation in 10 cases out of 19 experiments, (b) contraction in 6 cases, and (c) contraction followed by relaxation in 4 cases. The relaxation response to norepinephrine was reversed. in the presence of propranolol, to a contraction response which was then abolished after administration of regitine. The contraction response to norepinephrine was reversed, in the presence of regitine, to a relaxation response which was then abolished after administration of propranolol. Acetylcholine elicited contraction of the isolated detrusor muscle strip, and this was abolished in the presence of atropine These results suggest that the rabbit detrusor muscle is innervated by both cholinergic and adrenergic fibers and that the detrusor muscle contains cholinergic receptors as well as adrenergic a-and b-ones. Contrary to the popular opinion that the detrusor muscle predominantly contains adrenergic b-receptors, it seems likely that the adrenergic receptors differ in predominancy of either a or b which elicits contraction or relaxation, respectively, according to different areas of the muscle.
Acetylcholine ; Adrenergic Fibers ; Atropine ; Autonomic Agents* ; Electric Stimulation* ; Norepinephrine ; Phentolamine ; Propranolol ; Receptors, Adrenergic ; Receptors, Cholinergic ; Relaxation

BACKGROUND: The beta2 adrenergic receptor (beta2 AR) polymorphisms occurring at amino acid position 16 (Arg to Gly), 27 (Gln to Glu), 34 (Val to Met), and 164 (Thr to Ile) are known to be functionally relevant and also disease-modifying in subjects with asthma. However the contribution of these polymorphisms to the development of the asthmatic phenotype or other markers for allergic disease remains to be established. METHODS: 109 patients with bronchial asthma and 42 healthy person were included. Serum total IgE, allergen specific IgE, and skin prick test were performed to all of the subjects. beta2 AR polymorphisms were checked by mutated allele specific amplification (MASA) method. RESULTS: The results were as follows. The frequencies of beta2 AR polymorphisms in asthmatic patients and healthy person were not statistically different(p>0.05). There was no association between beta2 AR polymorphisms of amino acid position 16, 27, 34 and the existence of atopy among asthmatic patients (p>0.05). Between asthmatic patients with or without elevated IgE level and beta2 AR polymorphisms of amino acid position 16, 27, 34, there was no statistically significant association(p>0.05). CONCLUSION: There was no difference in frequency of the beta2 AR polymorphism between asthmatic patients and healthy person. In the bronchial asthma, association of beta2 AR polymorphism and atopy/serum total IgE was not found.
Alleles ; Asthma ; Humans ; Immunoglobulin E* ; Phenotype ; Receptors, Adrenergic ; Receptors, Adrenergic, beta-2 ; Skin

BACKGROUND AND PURPOSE: The purpose of this meta-analysis was to determine the precise association between beta-2 adrenergic receptor (beta2AR) polymorphism and Ischemic stroke. METHODS: Published case control studies on association between beta2AR and ischemic stroke were searched from electronic databases. Pooled Odds ratio and 95% Confidence interval were calculated by using software RevMan version 5.2. RESULTS: A total of three studies involving 1,642 cases and 1,673 controls, which were published from 2007 to 2014, were subjected to meta-analysis for allelic association and 518 cases and 510 controls for genotypic association. Pooled analysis of two studies for genotypic association suggested that subjects carrying Gln27Glu polymorphism of beta2AR had an increased risk for Ischemic stroke under recessive model (OR 2.09; 95% CI; 1.20 to 3.64) and under dominant model (OR 1.47; 95% CI 1.14 to 1.90). Pooled analysis of three studies for allelic association showed a significantly higher Glu27 allele of beta2AR in the patients with ischemic stroke (OR 1.58; 95% CI; 1.38 to 1.81). CONCLUSIONS: The present meta-analysis suggests that Gln27Glu polymorphism of beta2AR gene is associated with increased risk for ischemic stroke.
Alleles ; Case-Control Studies ; Cerebral Infarction ; Humans ; Odds Ratio ; Receptors, Adrenergic* ; Receptors, Adrenergic, beta-2 ; Stroke*

Recent reports suggest that the responses of the detrusor muscle to the hypogastric nerve stimulation and some autonomic drugs may not be identical among various species. In this study, the responses of the isolated detrusor muscle strips of the Amyda Japonica and the rabbit to catecholamines were compared, and the type of the adrenergic-receptors was investigated. The results obtained were as follows : 1. Catecholamines (norepinephrine and epinephrine) evoked only contraction in the isolated detrusor muscle of the Amyda Japonica and relaxation in the preparation of the rabbit. 2. The contraction-response in the Amyda Japonica was blocked in the presence of regitine, an adrenergic alpha-receptor blocking agent. 3. The relaxation-response in the rabbit was abolished by pre-treatment with propranolol, an adrenergic beta-receptor blocking agent. 4. Acetylcholine elicited contraction in both of the isolated detrusor muscle strips of the Amyda japonica and the rabbit, and the response was completely blocked in the presence of atropine. 5. The results described above suggest that catecholamines exert excitatory effect on the detrusor muscle of the Amyda japonica as it contains adrenergic alpha-receptors and inhibitory effect on the same preparation of the rabbit as it contains the adrenergic beta-receptors. Key Word : amyda japonica,alpha receptor, beta receptor.
Acetylcholine ; Atropine ; Autonomic Agents* ; Catecholamines ; Phentolamine ; Propranolol ; Receptors, Adrenergic, alpha ; Receptors, Adrenergic, beta ; Relaxation

Adrenergic receptors are members of the G-protein coupled receptor superfamily. Recent studies revealed that these adrenergic receptors are playing an important role in the growth and metastasis of prostate cancer cells. The expression of adrenergic receptors rises significantly in prostate cancer cells and tissues. Agonists of these receptors promote the growth and mobility of prostate cancer cells, while antagonists may suppress their proliferation, trigger their apoptosis, and inhibit their metastasis. Clinically, receptor antagonists can significantly reduce the risk of prostate cancer and improve its prognosis after androgen depravation therapy. This article presents an overview on the roles of adrenergic receptors in prostate cancer.
Adrenergic Agonists ; pharmacology ; Adrenergic Antagonists ; pharmacology ; Apoptosis ; Humans ; Male ; Prostatic Neoplasms ; metabolism ; pathology ; Receptors, Adrenergic ; drug effects ; physiology