1.Periodontopathogen profile of healthy and oral lichen planus patients with gingivitis or periodontitis.
Abdullah Seckin ERTUGRUL ; Ugur ARSLAN ; Recep DURSUN ; Sema Sezgin HAKKI
International Journal of Oral Science 2013;5(2):92-97
Oral lichen planus (OLP) is a chronic inflammatory disease that is frequently detected in oral tissues. The aim of our study was to identify the prevalence of the detection of periodontopathogenic microorganisms (Aggregatibacter actinomycetemcomitans, Porphyromonas gingivalis, Prevotella intermedia, Tannerella forsythia and Treponema denticola in OLP patients and to compare with this prevalence of periodontopathogenic microorganisms in healthy non-OLP patients. Our study included 27 (18 chronic periodontitis (OLPP) and 9 gingivitis (OLPG)) patients diagnosed with OLP along with 26 (13 chronic periodontitis (HP) and 13 gingivitis (HG)) healthy non-OLP patients. The multiplex polymerase chain reaction (PCR) with subsequent reverse hybridization method (micro-IDent) was used for identifying periodontopathogenic microorganisms present in subgingival plaque samples. The percentages of detection for A. actinomycetemcomitans, P. gingivalis, P. intermedia, T. forsythia and T. denticola in subgingival plaque samples taken from OLP patients (OLPG and OLPP) were 18.5%, 85.1%, 81.4%, 88.8% and 74%, respectively. Meanwhile, in the non-OLP patients (HG and HP), these values were 7.6%, 50%, 46.1%, 73% and 57.7%, respectively. Thus, comparing the non-OLP groups with the OLP groups, the periodontopathogens' percentages of detection in the OLP groups were higher than those in the non-OLP groups. According to our study results, OLP patients have higher levels of infection with A. actinomycetemcomitans, P. gingivalis, P. intermedia, T. forsythia and T. denticola than non-OLP patients. We argue that the high percentages in patients with OLP may help identify the importance of periodontopathogenic microorganisms in the progress of periodontal diseases of OLP.
Actinobacillus Infections
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diagnosis
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Adult
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Aggregatibacter actinomycetemcomitans
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isolation & purification
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Bacteroidaceae Infections
;
diagnosis
;
Bacteroides
;
isolation & purification
;
Bacteroides Infections
;
diagnosis
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Chronic Periodontitis
;
microbiology
;
Dental Plaque
;
microbiology
;
Dental Plaque Index
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Female
;
Gingivitis
;
microbiology
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Gram-Negative Bacteria
;
isolation & purification
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Humans
;
Lichen Planus, Oral
;
microbiology
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Male
;
Middle Aged
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Periodontal Attachment Loss
;
microbiology
;
Periodontal Index
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Periodontal Pocket
;
microbiology
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Porphyromonas gingivalis
;
isolation & purification
;
Prevotella intermedia
;
isolation & purification
;
Treponema denticola
;
isolation & purification
;
Treponemal Infections
;
diagnosis
2.Can Wideband Tympanometry Be Used as a Screening Test for Superior Semicircular Canal Dehiscence?
Emine DEMIR ; Nazife Nur AFACAN ; Metin CELIKER ; Fatma Beyazal CELIKER ; Mehmet Fatih İNECIKLI ; Suat TERZI ; Engin DURSUN
Clinical and Experimental Otorhinolaryngology 2019;12(3):249-254
OBJECTIVES: We explored whether wideband tympanometry (WBT) could be used as a screening test for superior semicircular canal dehiscence (SSCD), and obtained new WBT data (given that the test is not yet in common clinical use) on patients with SSCD. METHODS: We compared the WBT data of patients clinically and radiologically diagnosed with SSCD in our hospital between 2013 and 2018 to those of healthy volunteers. We compared the resonance frequency (RF), maximum absorbance frequency (MAF), and maximum absorbance ratio (MAR). The t-test was used for statistical analysis with the significance level set to P<0.05. In addition, we used receiver operating characteristic analysis to derive cutoff values for SSCD diagnosis in terms of sensitivity and specificity. RESULTS: Seventeen patients (four with bilateral and 13 with unilateral disease; 17 ears) diagnosed with SSCD and 27 healthy volunteers (47 ears) were included. The mean RFs of the SSCD patients and healthy subjects were 548.7 Hz (range, 243 to 853 Hz) and 935.1 Hz (range, 239 to 1,875 Hz), respectively (P<0.001). The mean MARs of the SSCD patients and healthy subjects were 89.4% (range, 62% to 100%) and 82.4% (range, 63% to 99%), respectively (P=0.005). The mean MAFs of the SSCD patients and healthy subjects were 1,706.3 Hz (range, 613 to 3,816 Hz) and 2,668 Hz (range, 876 to 4,387 Hz), respectively (P<0.001). In terms of SSCD diagnosis, a MAR above 86% afforded 81% sensitivity and 77% specificity; an RF below 728 Hz, 86% sensitivity and 81% specificity; and an MAF below 1,835 Hz, 79% sensitivity and 67% specificity. CONCLUSION: WBT may be a useful clinical screening test for SSCD. The RF and MAF were lower, and the MAR higher, in SSCD patients than in normal controls.
Acoustic Impedance Tests
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Diagnosis
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Healthy Volunteers
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Humans
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Mars
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Mass Screening
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ROC Curve
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Semicircular Canals
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Sensitivity and Specificity