1.Historical control data from 13-week repeated toxicity studies in Crj:CD (SD) rats.
Jung Min LEE ; Min Ah LEE ; Hyeon Nam DO ; Yun Ik SONG ; Re Ji Na BAE ; Hye Yeong LEE ; Sun Hee PARK ; Jin Seok KANG ; Jong Koo KANG
Laboratory Animal Research 2012;28(2):115-121
Reference ranges of standard experimental parameters are useful for comparisons in toxicology. The aim of this study was to collect data from 13-week repeated toxicity studies in Crl:CD (SD) rats, a strain widely used for toxicity and efficacy research, for establishing domestic reference values. Data on body weight, food consumption; urinalysis, hematological, and blood biochemical parameters; and organ weights were collected from 11 toxicity studies in 220 Crl:CD (SD) rats (110 males and 110 females). The studies had been performed at a single testing facility over the last 5 years and involved animals sourced from a single breeder. The findings were collated as means, standard deviations, percentages, and ranges. Urine volume, uterus weight, eosinophil, and basophil counts, and triglyceride, total bilirubin, and gamma-glutamyl transpeptidase levels showed standard deviations of 30% or more. These historical control data would help to interpret the effects of test substances in routine toxicity and efficacy studies.
Animals
;
Basophils
;
Bilirubin
;
Body Weight
;
Eosinophils
;
gamma-Glutamyltransferase
;
Humans
;
Male
;
Organ Size
;
Rats
;
Reference Values
;
Sprains and Strains
;
Toxicology
;
Urinalysis
;
Uterus