1.Rare bleeding disorders: spectrum of disease and clinical manifestations in the Pakistani population
Rafia MAHMOOD ; Asad MAHMOOD ; Maria KHAN ; Sadia ALI ; Saleem Ahmed KHAN ; Syed Raza JAFFAR
Blood Research 2020;55(3):146-150
Background:
Rare inherited coagulation factor deficiencies constitute an important group of bleeding disorders. A higher frequency of these disorders is seen in areas of high consanguinity.Our aim was to study the prevalence and spectrum of rare inherited bleeding disorders, characterize the severity of the deficiencies, identify different clinical manifestations, and evaluate different treatments provided.
Methods:
This cross-sectional study was conducted in the Department of Haematology, Armed Forces Institute of Pathology Rawalpindi, between January 2014 and December 2018.A detailed history was taken, and an examination was performed. The signs and symptoms were noted, and the patients were diagnosed on the basis of a coagulation profile. The disease severity was assessed using factor assays.
Results:
Among 2,516 patients with suspected coagulation disorders, 774 (30.8%) had an inherited bleeding disorder. Of the 774 patients, 165 (21.3%) had a rare bleeding disorder;91 (55.2%) of them were males, and 74 (44.9%) were females, with a male-to-female ratio of 1.2:1. The median patient age was 9 years 3 months. The most common disorder was factor VII deficiency (46 patients, 27.9%). The most common clinical presentation was bruising in 102 (61.8%) and gum bleeding in 91 (55.2%) patients.
Conclusion
The most common rare bleeding disorder in our population is factor VII deficiency. The prevalence of these bleeding disorders is high in our population due to a high number of consanguineous marriages.
2. Screening outcomes of household contacts of multidrug-resistant tuberculosis patients in Peshawar, Pakistan
Arshad JAVAID ; Anila BASIT ; Arshad JAVAID ; Mazhar Ali KHAN ; Sumaira MEHREEN ; Anila BASIT ; Muhammad IHTESHAM ; Irfan ULLAH ; Afsar KHAN ; Ubaid ULLAH ; Mir Azam KHAN ; Raza Ali KHAN
Asian Pacific Journal of Tropical Medicine 2016;9(9):909-912
Objective To assess the profile of TB/multidrug-resistant TB (MDR-TB) among household contacts of MDR-TB patients. Methods Close contacts of MDR-TB patients were traced in the cross-sectional study. Different clinical, radiological and bacteriological were performed to rule out the evidence of TB/MDR-TB. Results Between January 2012 and December 2012, a total of 200 index MDR-TB patients were initiated on MDR-TB treatment, out of which home visit and contacts screening were conducted for 154 index cases. Of 610 contacts who could be studied, 41 (17.4%) were diagnosed with MDR-TB and 10 (4.2%) had TB. The most common symptoms observed were cough, chest pain and fever. Conclusions The high incidence of MDR-TB among close contacts emphasize the need for effective contact screening programme of index MDR-TB cases in order to cut the chain of transmission of this disease.
3.A Longitudinal Survey for Genome-based Identification of SARS-CoV-2 in Sewage Water in Selected Lockdown Areas of Lahore City, Pakistan: A Potential Approach for Future Smart Lockdown Strategy.
Yaqub TAHIR ; Nawaz MUHAMMAD ; Z Shabbir MUHAMMAD ; A Ali MUHAMMAD ; Altaf IMRAN ; Raza SOHAIL ; A B Shabbir MUHAMMAD ; A Ashraf MUHAMMAD ; Z Aziz SYED ; Q Cheema SOHAIL ; B Shah MUHAMMAD ; Rafique SAIRA ; Hassan SOHAIL ; Sardar NAGEEN ; Mehmood ADNAN ; W Aziz MUHAMMAD ; Fazal SEHAR ; Hussain NADIR ; T Khan MUHAMMAD ; M Atique MUHAMMAD ; Asif ALI ; Anwar MUHAMMAD ; A Awan NABEEL ; U Younis MUHAMMAD ; A Bhattee MUHAMMAD ; Tahir ZARFISHAN ; Mukhtar NADIA ; Sarwar HUDA ; S Rana MAAZ ; Farooq OMAIR
Biomedical and Environmental Sciences 2021;34(9):729-733