1.Choroidal melanoma treated with linear accelerator-based hypofractionated stereotactic radiotherapy: First case of globe conservation in uveal melanoma from the Philippines.
Raymund V. TANCHULING ; Andrei P. MARTIN
Philippine Journal of Ophthalmology 2025;50(1):64-71
OBJECTIVE
This is a case report of a 60-year-old woman with a juxtapapillary choroidal melanoma who underwent globe-sparing treatment using linear-accelerator (LINAC)-based hypofractionated stereotactic radiotherapy (FSRT).
METHODSClinical data, ophthalmologic findings, and imaging results were obtained through retrospective chart review.
RESULTSAt three months and nine months post-treatment, tumor thickness decreased by 20.5% (from 13.00 mm to 10.34 mm) and 33.2% (to 8.69 mm), respectively. Partial resolution of subretinal fluid and vitreous hemorrhage was confirmed clinically and by B-scan. No metastatic spread was detected on liver ultrasound and chest radiography. Best-corrected visual acuity in the treated eye remained stable at hand motion. Radiation-induced dry eye was managed effectively with preservative-free sodium hyaluronate eye drops.
CONCLUSIONLINAC-based hypofractionated FSRT achieved marked local control and tumor regression in this case of a medium-large, juxtapapillary choroidal melanoma, while preserving the globe and the baseline vision. In regions without access to plaque brachytherapy, this technique offers a practical, cost-efficient, and multidisciplinary approach to eye-conserving therapy.
Human ; Female ; Middle Aged: 45-64 Yrs Old ; Radiotherapy ; Melanoma

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