There are rapid advancements in AI-driven diagnostics and wearable technologies, which are enabling early disease prediction, especially in conditions like Parkinson's disease. Precision medicine, underpinned by molecular biology and genomic data, allows clinicians to tailor treatment based on patient phenotypes, significantly enhancing personalized healthcare. AI complements this by processing vast datasets, from health records to biomarker evaluations, supporting more precise diagnostics and treatment recommendations.

Kennedys disease (KD) is a rare, slowly progressive neurodegenerative disorder of motor neurons in the spinal cord and brain stem. Most of the cases of KD in clinical practice are misdiagnosed. The knowledge of the initial presentation, the range of age within which the disease would manifest and the clinical course of the disease would be very helpful to better manage and anticipate the outcome of such cases. This report highlights the typical earliest presentation of KD and the clearcut clinical picture of KD that differentiates it from other motor neuron diseases of grave scenario and prognosis We report clinical details of 4 male patients with KD seen in our center. Diagnosis of these four patients were based on their clinical picture the time they were first seen. Common features in their history and presentation were the onset of prolonged and intermittent muscle cramps followed by weakness and atrophy of the muscles involved. All of them developed gynecomastia. Three of them have concomitant diabetes, and one has thyroid problem. All of them were initially diagnosed as Amyotrophic lateral Sclerosis.

Human ; Male ; Middle Aged ; Amyotrophic Lateral Sclerosis ; Bulbo-spinal Atrophy, X-linked ; Muscle Cramp ; Gynecomastia ; Motor Neuron Disease ; Nerve Degeneration ; Brain Stem ; Diabetes Mellitus

Islands ; Philippines ; Sequence Analysis, Dna ; Movement Disorders ; Dystonia ; Parkinsonian Disorders

I see clinicians often and when time is kind, a conversation about research ensues. There is always interest but to actually engage in research, many shake their heads and sigh “no time.” I wonder about lost opportunities to learn and study diseases when clinicians are not inclined to or not supported in research. At every stage of medical education, training, and professional practice whether in academia or in clinic or hospital, physicians inevitably encounter a fork in the road. The paths of clinician and/or academician are large lanes in the highway, yet at a junction, the highway becomes two roads, one to remain as clinician or academicians and the other to pursue research and publication. As well-known, many choose to remain in clinic or in classroom.
Research ; Publications

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