1.Esophagogastric Junction Outflow Obstruction Caused by Gabapentin
Maximilien BARRET ; Marie Anne GUILLAUMOT ; Chloé LÉANDRI ; Raphael GAILLARD ; Stanislas CHAUSSADE
Journal of Neurogastroenterology and Motility 2019;25(2):334-335
No abstract available.
Esophagogastric Junction
2.Immune Activation and Deficit in Neurotransmitters Synthesis in Treatment Resistant Depression: About a Case of Hashimoto Encephalopathy
Pierre ELLUL ; Matthieu GASNIER ; Vincent TREBOSSEN ; Raphael GAILLARD
Clinical Psychopharmacology and Neuroscience 2020;18(3):463-466
We report a case of Hashimoto encephalopathy initially presented as a drug-resistant depression with predominant apathy and asthenia, successfully treated with cyclophosphamide. We suspected that the psychiatric symptoms were due to a deficit in neurotransmitter synthesis related to immune activation. We hypothesized that the immunomodulatory treatment helped to restore the neurotransmitter synthesis and thus decreased the patient’s depressive symptoms. In this case report we propose an innovative model in which immunity might disturbs neurotransmitters synthesis leading to depressive symptoms.
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