Objective To evaluate the efficacy of ginkgo biloba extract injection combined mecobalamine treatment of diabetic peripheral neuropathy.Methods CNKI, CBM, VIP, Wanfang, PubMed, Cochrane library and Google academic search and other databases were searched, the RCT related ginkgo biloba extract injection combined mecobalamine treatment of diabetic peripheral neuropathy were collected.Meta analysis, drawing forest map and funnel plot by using Rev.Man 5 software.Results A total of 21 RCTs involving 1745 patients were obtained, 905 cases in experimental group and 840 cases in control group.Meta analysis showed that the total effective rate of the experimental group was better than that of control group ( RR=1.40, 95%CI:1.31-1.48), the conduction velocity of motor nerve median nerve(MD=5.39, 95%CI:3.90-6.87), common nerve(MD =5.33, 95%CI:3.82-6.83), sensory nerve median nerve (MD =4.31, 95%CI: 2.89-5.74)and common nerve (MD =4.10, 95%CI: 2.67-5.54)in experimental group were better than those of control group, the difference was statistically significant (P<0.05).Conclusion Ginkgo biloba extract injection plus cobalt-amine peripheral neuropathy in patients with diabetes treatment RCT design flaws, affecting the results of the authenticity and reliability; ginkgo biloba extract injection combined mecobalamine can improve the clinical efficacy and improve nerve conduction speed;due to less number of included studies, research quality is not uniform, still need to carry out more high quality randomized controlled trials to further validate the results.