1.Incidence of infusion-related reaction to monoclonal antibody rituximab: a national kidney and transplant institute experience.
Jose Enrique MONTOYA ; Herdee Gloriane LUNA ; Nunilon G VERGARA ; Jose Roberto AMPARO ; Gloria R CRISTAL-LUNA
Annals of the Academy of Medicine, Singapore 2012;41(3):125-126
Adult
;
Aged
;
Aged, 80 and over
;
Antibodies, Monoclonal, Murine-Derived
;
adverse effects
;
Antineoplastic Agents
;
adverse effects
;
Drug Hypersensitivity
;
etiology
;
Female
;
Humans
;
Incidence
;
Infusions, Intravenous
;
Male
;
Middle Aged
;
Premedication
;
adverse effects
;
Ranitidine
;
adverse effects
;
Retrospective Studies
;
Rituximab
2.Phytochemical Estimation and Therapeutic Amelioration of Aesculus hippocastanum L. Seeds Ethanolic Extract in Gastric Ulcer in Rats Possibly by Inhibiting Prostaglandin Synthesis.
Sahar IDRIS ; Anuradha MISHRA ; Mohammad KHUSHTAR
Chinese journal of integrative medicine 2023;29(9):818-824
OBJECTIVE:
To quantify phytochemicals using liquid chromatography and mass spectroscopy (LCMS) analysis and explore the therapeutic effect of Aesculus hippocastanum L. (AH) seeds ethanolic extract against gastric ulcers in rats.
METHODS:
Preliminary phytochemical testing and LCMS analysis were performed according to standard methods. For treatment, the animals were divided into 7 groups including normal control, ulcer control, self-healing, AH seeds low and high doses, ranitidine and per se groups. Rats were orally administered with 10 mg/kg of indomethacin, excluding the normal control group (which received 1% carboxy methyl cellulose) and the per se group (received 200 mg/kg AH seeds extract). The test group rats were then given 2 doses of AH seeds extract (100 and 200 mg/kg, respectively), while the standard group was given ranitidine (50 mg/kg). On the 11th day, rats in all groups were sacrificed, and their stomach was isolated to calculate the ulcer index, and other parameters such as blood prostaglandin (PGE2), tissue superoxide dismutase (SOD), catalase (CAT), malonyldialdehyde (MDA), and glutathione (GSH). All isolated stomach tissues were analyzed for histopathological findings.
RESULTS:
The phytochemical examination shows that the AH seeds contain alkaloids, flavonoids, saponins, phenolic components, and glycosides. LCMS analysis confirms the presence of quercetin and rutin. The AH seeds extract showed significant improvement in gastric mucosa conditions after indomethacin-induced gastric lesions (P<0.01). Further marked improvement in blood PGE2 and antioxidant enzymes, SOD, CAT, MDA and GSH, were observed compared with self-healing and untreated ulcer-induced groups (P<0.01). Histopathology results confirmed that AH seeds extract improved the mucosal layer and gastric epithelial membrane in treated groups compared to untreated ulcer-induced groups.
CONCLUSIONS
LCMS report confirms the presence of quercetin and rutin in AH seeds ethanolic extract. The therapeutic effect of AH seeds extract against indomethacin-induced ulcer in rat model indicated the regenerated membrane integrity, with improved cellular functions and mucus thickness. Further, improved antioxidant enzyme level would help to reduce PGE2 biosynthesis.
Rats
;
Animals
;
Stomach Ulcer/pathology*
;
Antioxidants/therapeutic use*
;
Ranitidine/adverse effects*
;
Aesculus
;
Ulcer/drug therapy*
;
Quercetin
;
Plant Extracts/chemistry*
;
Indomethacin/therapeutic use*
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Glutathione
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Superoxide Dismutase
;
Rutin/adverse effects*
;
Prostaglandins/adverse effects*
;
Phytochemicals/therapeutic use*
3.Clinical Features of Serious Adverse Drug Reactions in a Tertiary Care Hospital in Korea.
Yuri SEO ; Yeseul HAN ; Soo Hyun KIM ; Eun Sun SON ; Da Woon SIM ; Kyung Hee PARK ; Jung Won PARK
Korean Journal of Medicine 2017;92(4):392-400
BACKGROUND/AIMS: Several studies have reported on the clinical aspects of adverse drug reactions (ADRs). To date, no study has evaluated serious adverse drug reactions (SADRs) in Korea. The current study evaluates the clinical expression of SADRs in a Korean hospital. METHODS: We reviewed a total of 3,386 cases of SADR occurring between March 2012 and November 2015 in a single tertiary care institution (Regional Pharmacovigilance Center). RESULTS: When classified by organ system, the most common SADRs were white cell and reticuloendothelial system disorders (n = 511). Skin/appendage (n = 296) and gastrointestinal (n = 216) disorders were the fourth- and eighth-most common SADRs, respectively. The three most common single symptoms were leukopenia (n = 499 events), hypotension (n = 444) and anaphylaxis (n = 215). Leukopenia was mainly caused by anti-tumor drugs, followed by piperacilin/tazobactam (n = 28), vancomycin (n = 10) and methimazole (n = 6). Hypotension was most often caused by propacetamol injection (n = 145), while anaphylaxis was mainly caused by cefaclor (n = 19), ranitidine (n = 12), iopamidol (n = 10) and multi-vitamin infusion (n = 9). CONCLUSIONS: Significant differences were noted in the clinical aspects of ADRs and SADRs. Additional studies are warranted to further assess SADRs in response to frequently used causative drugs.
Anaphylaxis
;
Cefaclor
;
Drug Hypersensitivity
;
Drug-Related Side Effects and Adverse Reactions*
;
Hypotension
;
Iopamidol
;
Korea*
;
Leukopenia
;
Methimazole
;
Mononuclear Phagocyte System
;
Pharmacovigilance
;
Ranitidine
;
Tertiary Healthcare*
;
Vancomycin
4.Drug-Induced Anaphylaxis in a Single Korean Tertiary Hospital.
Il Joo MOON ; Hye Jung PARK ; Sung Ryeol KIM ; Beom Seok KOH ; Dong Woo LEEM ; Kyung Hee PARK ; Jae Hyun LEE ; Jung Won PARK
Korean Journal of Medicine 2015;88(3):281-287
BACKGROUND/AIMS: Drug-induced anaphylaxis (DIA) is a severe, acute, and potentially life-threatening condition. In Korea, only a few well-documented cases of DIA have been described. Therefore, the aim of this study was to investigate the clinical characteristics, causes, and management of DIA in a single Korean medical institute. METHODS: This was a retrospective medical record review of all DIA patients who visited the in-patient, out-patient, and emergency departments of our hospital from January 1 2006 to October 30 2013. RESULTS: Among 605 cases of anaphylaxis, 167 were drug-induced. The culprit drugs were contrast agents (43 cases, 25.7%), antibiotics (38, 22.8%), non-steroidal anti-inflammatory drugs (35, 21.0%), anti-cancer drugs (22, 13.2%), parenteral vitamins (9, 5.4%), ranitidine (6, 3.6%), and neuromuscular blockers (3, 1.8%). The most common organ-specific symptoms/signs were cardiovascular (74.3%), cutaneous (71.3%), respiratory (55.7%), and gastrointestinal manifestations (19.2%). In most cases, DIA was treated with antihistamines (77.2%) and systemic corticosteroids (76.5%); the use of epinephrine was considerably less frequent (35.3%). CONCLUSIONS: In our institution, contrast agents were the leading cause of DIA. Although epinephrine is the drug of choice in the treatment of acute anaphylaxis, fewer than 50% of the study patients received epinephrine to treat DIA.
Adrenal Cortex Hormones
;
Anaphylaxis*
;
Anti-Bacterial Agents
;
Contrast Media
;
Drug-Related Side Effects and Adverse Reactions
;
Emergency Service, Hospital
;
Epidemiology
;
Epinephrine
;
Histamine Antagonists
;
Humans
;
Korea
;
Medical Records
;
Neuromuscular Blockade
;
Neuromuscular Blocking Agents
;
Outpatients
;
Ranitidine
;
Retrospective Studies
;
Tertiary Care Centers*
;
Vitamins