Objective To investigate the effect of comprehensive nursing intervention in transcervical fracture after operation. Methods A total of 64 cases of transcervical fracture were retrospectively analyzed from the ward of depart-ment of orthopedics in our hospital, from February 2010 to February 2014, with thirty-two patients in each group. The control group adopted routine postoperative nursing in department of orthopedics and the intervention group adopted comprehensive nursing intervention. Then the postoperative mental state, joint function, complications and quality of life were compared between the two groups. Results Four weeks after operation, 12 patients happened pressure sores, 13 patients happened constipation, 11 patients happened infection in control group, and 3 patients happened pressure sores, 4 patients happened constipation, 3 patients happened infection in intervention group, there were significantly differences between the two groups (χ2=5.12~6.40, P<0.05). The psychological state of anxiety and depression was compared between the two groups after 4 weeks, in control group, anxiety and depression was (43.69±5.47) and (42.34± 5.24), while in intervention group, anxiety and depression was (37.26 ±6.18) and (36.36 ±4.87), there were significantly difference between two groups (t=4.40, 4.72, P<0.01). The joint function was compared between the two groups after 4 weeks, Harris score in intervention group and control group was (64.35±9.27) and (56.26±8.35) respectively, there was significantly difference between the two groups (t=3.67, P<0.01), and HSS score in intervention group and control group was (88.67±12.26) and (81.33±13.31) respectively, there was significantly difference between the two groups (t=3.67, P<0.01). 4 weeks after operation, activities, sleep, pain, self-care was compared between the two groups, the score was (37.42±4.62), (39.62±3.13), (29.25±3.15), (29.32±3.14) respectively in the control group, while the score was(41.13±6.73), (43.34±4.28), (31.61±3.57), (32.57±4.32) in the intervention group, there were significantly differences between the two groups (t=2.80~3.96, P<0.01). Conclusion Comprehensive nursing intervention can effectively reduce the postoperative complications of femoral neck fracture, improve the psychological state and joint function, and it can also improve the quality of life.

Objective To explore the changes and clinical significance of joint fluid TNF-α and TNF-β1 levels in patients with knee osteoarthritis (KOA). Methods A total of 90 patients with KOA hospitalized in our hospital were selected. They were assigned to group A with 30 patients at early stage, group B with 30 patients at medium stage,and group C with 30 patients at advanced stage according to the stage of X ray; 30 healthy volunteers were in the con-trol group. Levels of joint fluid TNF-αand TNF-β1 were tested in four groups of patients. Results Levels of joint fluid TNF-β1 at medium and advanced stages of KOA were significantly lower than those in the control group, and the dif-ferences were significant (P<0.01); Levels of joint fluid TNF-α at medium and advanced stages of KOA were signifi-cantly higher than those in the control group, and the differences were significant(P<0.01); the difference of levels of joint fluid TNF-α and TNF-β1 at early stage of KOA was not significant compared with those in the control group(P>0.05);levels of TNF-α/TNF-β1 at early,medium and advanced stage of KOA were significantly higher than those in the control group(P<0.01);TNF-αwas positively correlated with KOA stage(r=0.930,P<0.01);TNF-β1 was nega-tively correlated with KOA stage(r=-0.849,P<0.01);TNF-α/TNF-β1 was positively correlated with KOA stage(r=0.828,P<0.01). Conclusion TNF-α and TNF-β1 are involved in the formation and progression of OA, and levels of joint fluid TNF-α and TNF-β1 are able to reflect the severity of KOA lesions; joint fluid TNF-α/TNF-β1 is able to detect KOA early.