Acetylcysteine ; therapeutic use ; Animals ; Liver Cirrhosis, Experimental ; drug therapy ; Magnesium Compounds ; therapeutic use ; Rats ; Rats, Sprague-Dawley

Objective To study the effects of acetylcysteine magnesium on the vasoactive substances and hepatic fibrosis indexes in liver cirrhosis and portal hypertension of rats.Methods The rat liver cirrhosis model was made with 12 μg/kg dimethylnitrosamines.Then acetylcysteine magnesium was injected respectively with 25,50,and 100 mg· kg-1 dose daily into abdominal cavity.After 8 weeks treatment,pathological section,TGF-β1,NO,TNOS and iNOS of hepatic tissue were detected to assess the effect of acetylcysteine magnesium against cirrhosis portal hypertension.Results After the DMNA modeling was completed,the HE and Sweet reticulocyte staining of liver pathological section showed that cirrhosis of the liver was in the Ⅲ-Ⅳ phase,the infiltration of lymphocytes and formation of pseudolobuli in liver were alleviated in three acetylcysteine magnesium treatment groups (low,medium,and high dose),and the degree of liver fiber sclerosis in three groups was significantly lower than control group.Compared with control group,TGF-β1,NO,TNOS and iNOS were significantly reduced in all treatment groups(P ＜0.05).Conclusion Acetylcysteine magnesium is probably a distinctive antioxidant which can remove various free radical in body and modulate ligand-dependent signal transduction and the growth of cell.It also have protection in the liver cirrhosis and portal hypertension of rats induced by dimethylnitrosamine.

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