2.Application of real world study in neonatal medicine.
Yuan SHI ; Yan-Ru CHEN ; Long CHEN
Chinese Journal of Contemporary Pediatrics 2018;20(3):169-173
Real world study (RWS) has attracted more and more attention of neonatologists since it involves less clinical intervention and is closer to actual clinical conditions. Generally speaking, RWS means to select treatment measures based on the internal efficacy and safety verified by randomized controlled trials (RCTs), more representative samples, and patients' actual conditions and their guardians' will and conduct follow-up evaluation of short- and long-term outcomes, in order to further evaluate the external efficacy and safety of interventional measures. Most guidelines for clinical practice are based on RCTs and lack the support of real world data. Strengthening of neonatal RWS helps to make these guidelines more practical and thus promotes the development of neonatal medicine.
Humans
;
Infant, Newborn
;
Neonatology
;
Noninvasive Ventilation
;
Practice Guidelines as Topic
;
Pragmatic Clinical Trials as Topic
;
Randomized Controlled Trials as Topic
;
methods
4.Concealing Block Sizes Is Not Sufficient.
Clinics in Orthopedic Surgery 2015;7(3):422-423
No abstract available.
Humans
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Randomized Controlled Trials as Topic/*methods
5.Controlling methods of clinical research on acu-moxibustion commonly used of abroad.
Chinese Journal of Integrated Traditional and Western Medicine 2006;26(6):569-572
With the application of scientific studying methods, the level of clinical study has been improved greatly, and people has been paid more attention to scientific evaluation of the clinical effect of Chinese medicine and acu-moxibustion. Formerly, because of lack in acceptance and application of modern scientific studying methods in Chinese clinical acu-moxibustion researchers, their achievements weren't approved by the international academy for the faulty model of study. Randomized Control Trial (RCT) is the golden standard method widely accepted at present, so it is of great importance for clinical acu-moxibustion researchers to exert control methods correctly and effectively. The commonly used controlling methods of overseas clinical acu-moxibustion studies were discussed in this article in order to give some suggestion and benifits to the internal acu-moxibustion clinical researchers.
Acupuncture Therapy
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Humans
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Randomized Controlled Trials as Topic
7.Clinical study on the indications of 33 acupoints.
Yuan-Yuan ZHENG ; Zeng-Bin MA ; Liang-Xiao MA ; Nan-Nan GUO ; Chun LI ; Yan-Ping WANG ; Kai CHENG ; Huan YANG ; Wan-Ning LIU ; Lü-Wei JIN ; Jiang ZHU
Chinese Acupuncture & Moxibustion 2008;28(6):417-422
Multi-central randomized controlled method was used to scientifically verify indications of 33 acupoints and provide definite clinical basis for the indications of single acupoint. Of the 52 studies, 40 studies showed that the therapeutic effect in acupuncture observation groups were better than the control group; 11 studies showed similar therapeutic effect of the two groups, and 1 study showed the acupuncture observation group was worse than the control group. Therefore, results indicate that in a certain observation cycle, acupuncture at single acupoint have different effects on diseases.
Acupuncture Points
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Humans
;
Randomized Controlled Trials as Topic
9.Selection and application of explanatory and pragmatic randomized controlled trials in clinical research of acupuncture.
Rui-Min JIAO ; Wei-Juan GANG ; Yu-Qing ZHANG ; Xiang-Hong JING
Chinese Acupuncture & Moxibustion 2022;42(9):1073-1077
In the view of the controversy that there is no efficacy difference between true and sham acupuncture in acupuncture randomized controlled trials (RCTs), it is analyzed that one of the reasons is that many clinical studies do not properly understand the design of RCT research and interpret the research results. Starting from the concept and coverage of explanatory RCT and pragmatic RCT, this study lists the application examples of two types of RCTs in the field of acupuncture from five aspects: research purpose and trial environment, subject selection, intervention measures, control measures and outcome evaluation, so as to provide some ideas for their application in clinical trials.
Acupuncture Therapy/methods*
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Randomized Controlled Trials as Topic
10.Approach to Assess Adequacy of Acupuncture in Randomized Controlled Trials: A Systematic Review.
Lan-Jun SHI ; Zi-Yu TIAN ; Xiao-Yi HU ; Wen-Cui XIU ; Rui-Min JIAO ; Xiang-Yu HU ; Nicola ROBINSON ; Wei-Juan GANG ; Xiang-Hong JING
Chinese journal of integrative medicine 2023;29(8):730-737
OBJECTIVE:
To summarize and identify the available instruments/methods assessing the adequacy of acupuncture in randomized controlled trials (RCTs) for proposing a new improved instrument.
METHODS:
A systematic literature search was carried out in 7 electronic databases from inception until 21st November 2022. Any study evaluating the adequacy or quality of acupuncture, specifying specific acupuncture treatment-related factors as criteria of subgroup analysis, or developing an instrument/tool to assess the adequacy or quality of acupuncture in an RCT was included. Basic information, characteristics and contents of acupuncture adequacy assessment were presented as frequencies and percentages.
RESULTS:
Forty studies were included in this systematic review. Thirty-five studies (87.50%) were systematic reviews, none of which used formal methods to develop the assessment instruments/methods of acupuncture adequacy; of 5 methodological studies, only 1 study used a relatively formal method. Thirty-two studies (82.05%) assessed the components of acupuncture, while 7 (17.95%) assessed the overall quality of acupuncture. An independent assessment instrument/method was used to assess acupuncture adequacy in 29 studies (74.35%), whereas as one part of a methodological quality assessment scale in 10 (25.65%). Only 9 (23.00%) studies used the assessment results for subgroup analysis, sensitivity analysis or the criteria for inclusion in the meta-analysis.
CONCLUSION
Assessment contents for adequacy or quality of acupuncture in RCTs hadn't still reached consensus and no widely used assessment tools appeared. The methodology of available assessment instruments/scales is far from formal and rigorous. A new instrument/tool assessing adequacy of acupuncture should be developed using a formal method.
Acupuncture Therapy/methods*
;
Randomized Controlled Trials as Topic