AIM: To introduce a new kind of wrist-hand orthosis.METHODS: The major frame of wrist-hand orthosis is composed of dorsal carpal guard plate and carpal bracket; while, a U-shaped anterior bracket is fixed on the anterior side of the major frame. Ferrules of index finger, middle finger, fourth finger and little finger respectively connect to dorsal carpal guard plate of the major frame via elastic brace; ferrule of thumb is fixed on one side of ferrule of index finger by using steel wires; an abduct elastic sleeve is designed on the lateral dorsal carpal guard plate of ferrule of little finger by using steel wires. According to experimental demands, wrist with the palms upward or downward puts into the major frame, which is composed of dorsal carpal guard plate and carpal bracket. The hand is anterior to the major frame; ferrules are located over rolling sleeve by forward and fingers are located below the rolling sleeve by forward; ferrules are respectively rang the index, middle, fourth and little fingers; ferrule of thumb is rang the thumb. Continuously, wrist rotates based on orthopaedic demands to realize various orthopaedic functions.RESULTS: The wrist-hand orthosis is used to help the hand maintain extension after extensor tendon injury operation in order to restrict active areas of fingers and promote healing of injured side. On the other hand, this new orthosis is also used to help wrist joint and digital joint maintain flexion after extensor tendon injury operation in order to improve flexion and extension of wrist joint, enlarge active area of flexion of wrist joint, enlarge drifting active area of radialis of wrist joint, and increase muscle strength of radial flexor muscle, ulnar flexor muscle, extensor carpi radialis muscle, extensor carpi ulnaris muscle, extensor carpi ulnaris muscle, flexor carpi ulnaris muscle, extensor digitorum communis muscle, superficial flexor muscle and deep flexor muscle.CONCLUSION: The wrist-hand orthosis refers to protection of wrist and hand after operations of nerve, tendon, muscle and vessel injuries and recovery of motor dysfunction of wrist joint and digital joint induced by wrist-hand fracture; on the other hand, this new orthosis can improve active area of wrist joint and strengthen muscle force.

Capillary leak syndrome (CLS) is a common and life-threatening disorder in children.The common pathogenies are sepsis,severe trauma,shock,asphyxia,extracorporeal circulation,ischemical reperfusion injury and so on.It is characterized by shock resulting from leakage of plasma,which is refected by accompanying hemoconcentration,hypoalbuminemia and edema,sometimes followed by multiple organ dysfunction syndrome.Clinicians should consider the diagnosis in patients with unexplained edema and hypotension.To know the pathophysiology and clinical course will be benefit to proper medicine choosen.

Objective To investigate the clinical effect of the MBT straight wire technique for treatment of angle class Ⅱ 1 patho-occlusion.Methods 62 cases of adult class Ⅱ division 1 patients were randomly divided into the observation group (32 cases) and the control group (30 cases).The observation group was treated with MBT straight wire appliance therapy,the control group received the traditional straight wire appliance therapy.The two groups were given cephalometric film before and after treatment,and the clinical effect was observed and recorded.Results In the observation group,there were no significant differences in SNA,SNB,ANB,LI-MP,MP-SN after treatment compared with before treatment (t =0.46,0.73,0.24,1.05,P ＞ 0.05),while there were statistically significant differences in ANB,U1-SN,U1-L1 after treatment compared with before treatment (t =1.58,6.32,7.43,P ＜ 0.05).Before treatment 7 mm of openbite,OB 2 mm after treatment,returned to normal overbite and overjet,there was statistically significant difference(t =3.26,P ＜ 0.05).The mean treatment time was (22.0 ± 2.5) months in the observation group,it was significantly lower than(3 1.0 ± 3.8)months in the control group,there was statistically significant difference (t =7.47,P ＜ 0.05).After treatment,U1-SN,U1-L1 and OB in the observation group were significantly better than those of the control group,there were statistically significant differences(t =5.47,3.43,5.41,1.67,all P ＜ 0.05).Conclusion MBT straight wire appliance has the advantages of simple operation,accurate positioning of teeth,simplified correction procedure and short treatment time,it is worth the clinical promotion.

Objective To explore the expression of Pokemon protein and p53 protein in ovarian carcinoma and assure the relationship with clinicopathologic parameters.Methods 52 cases of ovarian cancer were enrolled as the observation group,60 cases of benign ovarian tissue as the control group.Expression of Pokemon protein and p53 protein were detected by immunohistochemistry.Results The positive rate of Pokemon protein were respectively 69.2％ (36/52) in the observation group and 11.7％ (7/60) in the control group,a significant differences between the two groups (x2 =12.74,P ＜0.01).The positive rate of p53 protein were respectively 78.8％ (41/52) in the observation group and 15.0％ (9/60) in the control group,a significant differences between the two groups(x2 =22.71,P ＜ 0.01).Pokemon protein expression were associated with ovarian cancer tumor invasion depth (x2 =9.16,P ＜ 0.05),clinical stage(x2 =5.86,P ＜ 0.05),lymph node metastasis (x2 =32.28,P ＜ 0.01) and recurrence (x2 =27.08,P ＜ 0.01) and no significant relationship with tumor differentiation (x2 =0.82,P ＞ 0.05).p53 protein expression were associated with ovarian cancer tumor invasion depth (x2 =8.24,P ＜ 0.05),clinical stage (x2 =9.24,P ＜ 0.05),lymph node metastasis (x2 =19.62,P ＜ 0.01) and recurrence (x2 =21.16,P ＜ 0.01) and no significant relationship with tumor differentiation(x2 =0.77,P ＞0.05).By correlation analysis,Pokemon protein expression had a significant positive correlation and p53 protein(r =0.297,P ＜ 0.05).Conclusion Pokemon protein and p53 protein had closely related with diagnosis,lesion degree and prognosis in ovarian cancer.

Objective:To study acute toxicity of Xidan suspensions in mice.Methods:To measure the LD50 and to observe the response to machinery stimulation and the autonomic activity of the experimental animals when Xidan suspensions is taken orally into the mice.Results:The LD_(50) of Xidan suspensions is 148.08g(crude medicinal materials)/kg in the mice by ig.When it is taken orally(ig)into the mice at the dosage of LD_(50) or more [180g(crude medicinal materials)/kg],it is found that the response to machinery stimulation,the autonomic activity the muscle tone and the regulation of balance ability decreased obviously.Conclusion:It is indicated that Xidan suspensions could be toxic to the nervous system of mice.

Recent advances in carbohydrate metabolism in cancer stem cells were obtained by analyzing the key words in relation with carbohydrate metabolism in cancer stem cells, which are covered in cluster-derived databases ( GoPubMed, XplorMed, AnneO'Tate, MEDSUM, PubReMiner) , with the basic strategies and use characteristics of these 5 databases compared, in order to provide the effective retrieval tools for embedded subject service in li-brary.

Objectives: To find out influencing factors of quality of life(QOL) of staffs in Centers for Disease Prevention and Control(CDC),whose results would be taken as theoretical evidence for government policy-makers to work out strategy of health human resources.Methods: The WHO Quality of Life Brief Scale(WHOQOL-BREF) was employed as the assessing tool for staffs of CDC who were in a city and its neighborhood counties.Each subject was asked to complete a spot self-assessment.Results: There is no significant difference of QOL of staffs between city and neighborhood county.Working at different departments was one of the influencing factors on psychological and social domains.Harmonious family relationship,good appetite,agreement to work competition,and confidence in working institutes were influencing factors to the total score of QOL.Conclusions: Scores of QOL of CDC staffs were relatively low with various influencing factors.It is necessary for leaders of related departments to take countermeasures to improve the QOL of CDC staffs.

In medical researches,large-scale collaborations spanning institutions and disciplines have emerged a key pattern for tackling major research subjects.Contract writing for medical research collaboration,as a legal means to address the rights and obligations of the parties,should be fair,reasonable,scientific and strict as much as possible.The author probed into problems found in current writing of medical research contracts,and came up with corresponding remedies.

Objective To explore the clinical significance of detecting serum interleukin (IL)-6 in patients with esophageal squamous cell carcinoma(ESCC).Methods We detected the serum level of IL -6 in 35 patients with ESCC(observation group)and 35 healthy controls (control group)by double antibody sandwich enzyme -linked immunosorbent assay(ELISA),and then analyzed its clinical value.Results The serum levels of IL -6 in the observation group (27.66 ±2.30)ng/L was significantly higher than (17.72 ±3.62)ng/L in the con-trol group (t =11.63,P <0.01).There was significant difference in the serum level of IL -6 in the observation group preoperation and postoperation [(27.66 ±2.30)ng/L vs (23.62 ±3.27)ng/L,t =5.12,P <0.01].The serum level of IL -6 in the observation group preoperation was relevant with clinical stages(χ2 =11.15,P <0.01).Conclusion The change of serum IL -6 level in patients with ESCC is related to the occurrence and development of ESCC,which is an important indication for diagnosis and prognosis.

Objective:To investigate the false alarm rate of electrocardiogram monitor, and to develop methods to exclude interference. Methods:A total of 52 patients in emergency room in hospital in March 2014 were in the control group. The frequency and causes of false alarms of the electrocardiogram monitor were recorded. At the meantime, the improvements were analyzes. A total of 52 patients in emergency room in hospital in May 2014 were chose to be the experimental group. The frequency and causes of false alarms of the electrocardiogram monitor were recorded after some improvements. Results: In control group, the total of alarms rate were 5376 times, including 2208 times of false alarms. The false alarm rate was 41.07%. While in the experimental group, there were 2634 alarms, including 798 times of false alarms. The false alarm rate was 30.29%. Compared to the control group(x2=25.77, P<0.05). It was statistically significant difference. Conclusion:Intervention on Mindray electrocardiogram monitor can reduce the false alarm rate, help to improve the efficiency of nurses and ensure safety to patients.