1.Seasonal or Gender Effects on Cord Serum Insulin-like Growth factor-I Concentrations in Newborn Infants.
Ran NAMGUNG ; Chul LEE ; Dong Gwan HAN
Korean Journal of Perinatology 1997;8(1):27-31
Possible seasonal differences in serum Insulin-Like Growth Factor-I (IGF-I) concentrations have not been studied in newborn infants. Recently we demonstrated sea- sonal differences in bone mineral content (BMC) in newborn infants: lower BMC was present in summer vs. winter-born infants (J Pediatr Gastroenterol Nutr 1992; 15: 285). In a second stduy, higher serum osteocalcin, an index of bone formation, and lower BMC were found in summer vs. winter (J Pediatr Gastroenterol Nutr 1994; 19: 2207). We speculated that increased serum osteocalcin in summer could be an adaptive response to decreased bone mass. Since growth factors such as IGFs are local regulators of bone formation, we hypothesized that in summer-born infants, serum IGF-I will be higher than in winter, associated with high bone formation activity. Fifty-nine healthy, term appropriate for gestational age (AGA) infants were studied prospectively in winter (Jan-Mar, 29) and in summer (July-Sept., 30). Thirty infants were male, and 29 infants were female. Gestational ages and birth weights were not different by season(in summer, mean+SD, 39.61.1 wk, 3,471360 g,' in winter, 39.31.4 wk, 3,402 392 g). Cord serum IGF-I was measured by radioimmunoassay, modified from Furlanetto et al (1977), after acidification and sep-pack extraction of serum, and osteocalcin concentrations were determined by a kit radio-immunoassay. Cord serum IGF-I concentrations were not different by season of birth(summer vs. winter, 20.11.83 vs. 16.5 1.75 ng/mL, p=0.2). No gender differences were found: 18.21.8 vs. 18.2+1.8 ng/ mL in males vs. females. Serum osteocalcin was higher in summer vs. winter-born infants (8.22.3 vs. 4.951.58 ng/mL, p=0.009). BMC was different by season (87.2+ 14.5 vs. 94.1+16.4 mg/cm, p=0.02). Cord serum IGF-I was not related to serum osteocalcin and BMC. We conclude that serum IGF-I concentrations are not different by season or gender, and are not related to bone formation activity and BMC. Thus, IGF -I concentrations in serum are not seasonally regulated, nor associated with an index of bone formation activity.
Birth Weight
;
Bone Density
;
Female
;
Gestational Age
;
Humans
;
Infant
;
Infant, Newborn*
;
Insulin-Like Growth Factor I
;
Intercellular Signaling Peptides and Proteins
;
Male
;
Osteocalcin
;
Osteogenesis
;
Prospective Studies
;
Radioimmunoassay
;
Seasons*
2.Exogenous Surfactant Replacement Therapy of Hyaline Membrane Disease: A controlled clinical trial.
Ran NAMGUNG ; Chul LEE ; Kook In PARK ; Dong Gwan HAN
Journal of the Korean Pediatric Society 1990;33(1):22-35
No abstract available.
Humans
;
Hyalin*
;
Hyaline Membrane Disease*
;
Infant, Newborn
3.A Study on the Blood Pressure Measurements in Newborn.
Ran NAMGUNG ; Ki Soo PAI ; Chul LEE ; Dong Gwan HAN
Journal of the Korean Pediatric Society 1988;31(5):541-546
No abstract available.
Blood Pressure*
;
Humans
;
Infant, Newborn*
4.Postnatal Weight Curve in Low Birth Weight(Appropriate for Gestational Age) Infants.
Kyoung Mi PARK ; Ran NAMGUNG ; Chul LEE ; Dong Gwan HAN
Journal of the Korean Pediatric Society 1989;32(5):606-619
No abstract available.
Humans
;
Infant*
;
Parturition*
5.7 Cases of Group B Streptococcal Meningitis and Sepsis.
Young Wan KIM ; Ran NAMGUNG ; Chul LEE ; Dong Gwan HAN
Journal of the Korean Pediatric Society 1988;31(7):873-880
No abstract available.
Meningitis*
;
Sepsis*
6.The Result of Intensive Care on the very Low Birth Weight Infants(1001~1500gm).
Seo Jeong KIM ; Ran NAMGUNG ; Chul LEE ; Dong Gwan HAN
Journal of the Korean Pediatric Society 1988;31(1):29-39
No abstract available.
Humans
;
Infant, Very Low Birth Weight*
;
Critical Care*
7.Clinical observation in the Clavicle Fracture in Newborn.
Kee Hyuck KIM ; Ran NAMGUNG ; Chul LEE ; Dong Gwan HAN
Journal of the Korean Pediatric Society 1986;29(12):35-39
No abstract available.
Clavicle*
;
Humans
;
Infant, Newborn*
8.Clinical observation in the Clavicle Fracture in Newborn.
Kee Hyuck KIM ; Ran NAMGUNG ; Chul LEE ; Dong Gwan HAN
Journal of the Korean Pediatric Society 1986;29(12):35-39
No abstract available.
Clavicle*
;
Humans
;
Infant, Newborn*
9.Effect of fluid restriction on postnatal weight and outcome in very low birth weight infants.
Chul LEE ; Hyeon Soo LEE ; Ran NAMGUNG ; Dong Gwan HAN
Journal of the Korean Pediatric Society 1991;34(3):348-354
No abstract available.
Humans
;
Infant*
;
Infant, Very Low Birth Weight*
10.Effect of fluid restriction on postnatal weight and outcome in very low birth weight infants.
Chul LEE ; Hyeon Soo LEE ; Ran NAMGUNG ; Dong Gwan HAN
Journal of the Korean Pediatric Society 1991;34(3):348-354
No abstract available.
Humans
;
Infant*
;
Infant, Very Low Birth Weight*