Squamous cell carcinoma in situ or Bowens disease is a precancerous keratinocyte lesion with the potential to progress into invasive squamous cell carcinoma. Several treatment modalities exist. Imiquimod is a topical immune response modifier with antitumor effects through the induction of local production of cytokines, particularly interferon alfa (IFN-a), interleukins 1, 6, 8, and 12, and tumor necrosis factor-a (TNF-a) This is the case of a 54-year-old female with biopsy-proven, Bowens disease over the right lower quadrant of the abdomen treated with once-daily application of imiquimod 5 percent cream for 9 weeks. Posttreatment biopsy showed no histologic evidence of Bowens disease.
Human
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Female
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Middle Aged
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Aminoquinolines
;
Bowen's Disease
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Carcinoma, Squamous Cell
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Cytokines
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Interferon-alpha
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Keratinocytes
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Skin Neoplasms
;
Tumor Necrosis Factor-alpha