2.Plasmacytoma of the pancreas: an unusual manifestation of multiple myeloma.
Susan Swee Shan HUE ; Rafay AZHAR
Singapore medical journal 2013;54(5):e105-7
Extramedullary plasmacytoma of the pancreas is a rare entity. Although this condition is uncommon, it should be considered in the differential diagnosis of solid mass in the pancreas, especially in patients with underlying multiple myeloma. We report a case of pancreatic plasmacytoma in a 56-year-old woman with newly diagnosed multiple myeloma. We highlight this rare manifestation of multiple myeloma among other better recognised presentations.
Diagnosis, Differential
;
Female
;
Humans
;
Immunohistochemistry
;
Keratins
;
metabolism
;
Middle Aged
;
Multiple Myeloma
;
diagnosis
;
pathology
;
Pancreas
;
pathology
;
Pancreatic Neoplasms
;
diagnosis
;
pathology
;
Plasmacytoma
;
diagnosis
;
pathology
;
Syndecan-1
;
metabolism
3.Single centre experience of transjugular liver biopsy in 152 patients.
Ankur PATEL ; Apoorva GOGNA ; Farah Gillan IRANI ; Terence K B TEO ; Tow Non YEOW ; Deepak JAIN ; Richard H G LO ; Kiang Hiong TAY ; Bien Soo TAN ; Rafay AZHAR ; Jason P E CHANG ; Manish TANEJA
Annals of the Academy of Medicine, Singapore 2014;43(3):160-165
INTRODUCTIONLiver biopsy is considered the definitive investigation in the diagnosis and management of liver disease. This study describes the experience of performing transjugular liver biopsy (TJLB) over the last 9 years in a local single centre.
MATERIALS AND METHODSA retrospective review of consecutive TJLB procedures performed at our institution was conducted. A total of 152 patients (74 males and 78 females), with a mean age of 47.4 years (range, 13 to 83 years) underwent a total of 154 TJLB procedures at our institution between March 2003 and November 2011. The principal indication for TJLB was severe coagulopathy in over 80% of patients. The technical success, number of passes, histological adequacy and complication rates were analysed.
RESULTSThe procedural success rate was 98.7% (152 out of 154 procedures). Adequate material for diagnosis was obtained in 149 out of 152 (98.0%) technically successful procedures. There was procedure related morbidity in 8 patients (5.2%) of which all but one were self-limiting requiring no further intervention. We also performed hepatic venous pressure gradient (HVPG) measurements in 19% of patients at the time of TJLB.
CONCLUSIONTJLB performed at our institution is a safe and reliable technique in patients in whom traditional percutaneous liver biopsy may be hazardous. TJLB has a high technical success rate as well as a high diagnostic yield with a low complication rate. TJLB also has the added benefit of performing HVPG, which is of increasing importance in management and prognostication of chronic liver disease.
Adolescent ; Adult ; Aged ; Aged, 80 and over ; Biopsy ; methods ; Female ; Humans ; Jugular Veins ; Liver ; pathology ; Liver Diseases ; pathology ; Male ; Middle Aged ; Retrospective Studies ; Young Adult