This article summarizes recent evidence on the cortical bone trajectory (CBT) obtained from published anatomical, biomechanical, and clinical studies. CBT was proposed by Santoni in 2009 as a new trajectory that can improve the fixation of pedicle screws in response to screw loosening in osteoporotic patients. Recently, research interest has been growing with increasing numbers of published series and frequent reports of new applications. We performed an online database search using the terms “cortical bone trajectory,”“pedicle screw,”“CBT spine,”“CBT fixation,”“MISS CBT,” and “traditional trajectory.” The search included the PubMed, Ovid MEDLINE, Cochrane, and Google Scholar databases, resulting in an analysis of 42 articles in total. These covered three aspects of CBT research: anatomical studies, biomechanical parameters, and clinical cases or series. Compared to the traditional trajectory, CBT improves pullout strength, provides greater stiffness in cephalocaudal and mediolateral loading, and shows superior resistance to flexion/extension; however, it is inferior in lateral bending and axial rotation. CBT seems to provide better immediate implant stability. In clinical studies, CBT has shown better perioperative results for blood loss, length of stay in hospital, and surgery time; similar or better clinical postoperative scores; and similar comorbidity, without any major fixation system complications due to instrumentation failure or screw misplacement. In addition, advantages such as less lateral exposure allow it to be used as a minimally invasive technique. However, most of the clinical studies were retrospective case series or case-control studies; prospective evidence on this technique is scarce, making a definitive comparison with the traditional trajectory difficult. Nevertheless, we can conclude that CBT is a safe technique that offers good clinical results with similar biomechanical and perioperative parameters to those of the traditional trajectory. In addition, new applications can improve its results and make it useful for additional pathologies.
Case-Control Studies ; Comorbidity ; Humans ; Length of Stay ; Pathology ; Pedicle Screws ; Prospective Studies ; Retrospective Studies

STUDY DESIGN: Cadaveric study. PURPOSE: The purpose of this study was to assess the accuracy and feasibility of cervical pedicle screw (CPS) insertion into the subaxial cervical spine placed using a patient-specific drill guide template constructed from a stereolithographic model. OVERVIEW OF LITERATURE: CPS fixation is an invaluable tool for posterior cervical fixation because of its biomechanical advantages. The major drawback is its narrow corridor that allows very little clearance for neural and vascular injuries. METHODS: Fifty subaxial pedicles of the cervical vertebrae from five cadavers were scanned into thin slices using computed tomography (CT). Digital imaging and communications in medicine images of the cadaver spine were digitally processed and printed to scale as a three-dimensional (3D) model. Drill guide templates were manually moulded over the 3D-printed models incorporating pins inserted in the pedicles. The drill guide templates were used for precise placement of the drill holes in the pedicles of cadaveric specimens for pedicle screw fixation. RESULTS: The instrumented cadaveric spines were subjected to CT to assess the accuracy of our pedicle placement by an external observer. Our patient-specific drill guide template had an accuracy of 94%. CONCLUSIONS: The use of a patient-specific drill guide constructed using stereolithography improved the accuracy of CPS placement in a cadaveric model.
Cadaver ; Cervical Vertebrae ; Female ; In Vitro Techniques* ; Pedicle Screws* ; Printing, Three-Dimensional ; Spine* ; Vascular System Injuries

Thalidomide is an immunomodulatory drug (IMiD) with proven therapeutic action in several autoimmune/inflammatory diseases; however, its inherent high toxicity has led to the development of more powerful and safer thalidomide analogs, including lenalidomide and pomalidomide. These are new generation IMiDs that exhibit direct antitumor activity as well as anti-inflammatory/immunomodulatory properties, and are FDA-approved for the treatment of several hematological malignances. Here we investigated the potential therapeutic effects of lenalidomide and pomalidomide in several experimental murine models of autoimmune/inflammatory diseases: 2,4,6-trinitrobenzene sulfonic acid- and dextran sulfate sodium-induced inflammatory bowel disease and type II collagen-induced arthritis. Lenalidomide displayed a strong therapeutic effect in all these models of autoimmune/inflammatory diseases, while the effect of pomalidomide was less pronounced. In vitro experiments confirmed the immunosuppressive effect of both IMiDs on the proliferative response of stimulated human lymphocytes and on the balance of secreted cytokines toward an anti-inflammatory profile. We conclude that lenalidomide may offer a therapeutic opportunity against autoimmune/inflammatory diseases.
Arthritis, Experimental ; Arthritis, Rheumatoid* ; Cytokines ; Dextran Sulfate ; Humans ; In Vitro Techniques ; Inflammatory Bowel Diseases* ; Lymphocytes ; Models, Theoretical* ; Thalidomide ; Therapeutic Uses

Introduction: The maturation process of peloids has been the subject of many studies over time. Knowledge of the processes occurring during this time period, it is very interesting to know the applications of the final product. Material and Method: For preparation of extemporaneous peloids it has been used clay Bentonite Volcangel (Benesa) supplied by Süd Chemie, a mineral water hyperthermal (42°C), sulphurated, weak mineralization (261 mg/l) from Baños Montemayor (M) and water purified obtained by distillation and ion exchange (A).   Peloids were prepared by mixing in the ratio needed aiming to produce a product with 70% water and clay, in polymeric material containers. Water and clay were mixed slowly until total homogenization. The product was introduced into glass containers tightly closed and kept at a constant temperature of 42°C and 8°C.   The percentage of the solid components, water and ashes was determined by gravimetric techniques, drying the sample in oven and muffle furnace (850°C). The specific heat and calorific retentivity were calculated from these data.   　Every six weeks, the analysis of all parameters are repeated in samples maintained at 42°C and 8°C to study possible variations. Results: In Table 1 are shown values of the parameters of the initial peloids prepared with purified water and mineromedicinal water. Conclusion: There were no significant differences observed in the values of the analyzed parameters between the two initial peloids prepared with purified water and with medicinal mineral water of Montemayor spa and a slight diminution in the water percentage, and a small increase of the relaxation time six weeks later.

Recently, porous titanium granules (PTGs) have been indicated for the preservation of the dimensions of post-extraction sockets, as a filler in sinus lift procedures and for the treatment of peri-implant and periodontal defects, based on the osteoconductivity and dimensional stability of the titanium granules. However, there is a lack of information regarding the use of this material in larger defects and in conjunction with membranes. The objective of this study is to test the behavior of PTGs used to fill critical size defects in rabbit tibiae, with and without membranes. Critical defects were created in both tibiae of rabbits, divided randomly into three groups: Group A (defect filled with PTG), Group B (defect filled with PTG+collagen membrane) and a control group (empty defect). After six weeks, histomorphometric analysis was performed. The results showed more defect closures at the cortical area (87.37%±2.2%) and more bone formation at the marrow area (57.6%±1.3%) in Group B, in comparison with the other groups (P<0.05); the use of membranes improved the material stability expressed as more percentages of the original material when membranes were used (P<0.05). Finally, inflammatory reactions were observed when the granules were not protected by membranes. In spite of the limitations of this animal study, it may be concluded that PTG particles are osteoconductive and allow bone growth. The PTG particles must be covered by a membrane, especially when grafting larger defects, in order to control particle migration, promote clot stabilization and separate the PTG graft from undesired soft tissue cells.
Animals ; Male ; Membranes, Artificial ; Rabbits ; Tibia ; abnormalities ; Titanium ; chemistry