1.A Comparison of Inhalation Anesthesia with Enflurane and Intravenous Anesthesia with Ketamine Hydrochloride in Lung Surgery of Patients with Decreased Pulmonary Function.
Do Hyun KWON ; Hee Kwon PARK ; Keun Seok MO ; Kyung Cheon LEE ; Young Rae CHO
Korean Journal of Anesthesiology 1997;33(3):447-452
BACKGROUND: Serious pulmonary complications after lung surgery increase morbidity and mortality in perioperative period. Ketamine hydrochloride produces strong analgesic effect in spite of the psychomimetic effects. Intravenous anesthesia with ketamine was performed in lung surgery of patients with decreased pulmonary function and compared with inhalation anesthesia with enflurane. METHODS: Sixty patients, scheduled for elective lung surgery, were randomly assigned to two groups. Patients received either enflurane (Group 1, n=30) or ketamine (Group 2, n=30) as main anesthetic drug. Blood pressure and heart rate were compared in preinduction, postinduction, postintubation, postincision, intraoperative period (30 minutes, 60 minutes) and recovery room between groups, and in each group. Arterial blood gas analysis was compared in preoperative period, intraoperative period and recovery room between groups. Postoperative psychological complications evaluated in group 2. RESULTS: Blood pressure and heart rate were significantly different in postinduction, postintubation and recovery room between groups. PaO2 in group 2 was higher than in group 1 during intraoperative period and recovery room. Postoperative psychological complications occured in 4 patients (13%) in group 2. CONCLUSIONS: Ketamine affords advantage over enflurane anesthesia in terms of PaO2 during intraoperative period and recovery room in lung surgery of patients with decreased pulmonary function.
Anesthesia
;
Anesthesia, Inhalation*
;
Anesthesia, Intravenous*
;
Blood Gas Analysis
;
Blood Pressure
;
Enflurane*
;
Heart Rate
;
Humans
;
Inhalation*
;
Intraoperative Period
;
Ketamine*
;
Lung*
;
Mortality
;
Perioperative Period
;
Preoperative Period
;
Recovery Room
2.A case of giant nasopharyngeal malignant fibrous histiocytoma(MFH) causing acute respiratory distress.
Uk LIM ; Chan Sik SHIN ; Kyung Rae KIM ; Hyung Seok LEE
Korean Journal of Otolaryngology - Head and Neck Surgery 1993;36(1):150-155
No abstract available.
3.Study of nasal resistance by rhinomanometry.
Uk LIM ; Chang Sik SHIN ; Kyung Rae KIM ; Hyung Seok LEE ; Sun Kon KIM
Korean Journal of Otolaryngology - Head and Neck Surgery 1993;36(4):672-682
No abstract available.
Rhinomanometry*
4.Labial salivary gland biopsy in Sjogren's syndrome.
Hye Ok KIM ; Hyeon Jo KIM ; Jong Il CHOI ; Kyung Rae KIM ; Hyung Seok LEE
Korean Journal of Otolaryngology - Head and Neck Surgery 1991;34(1):136-142
No abstract available.
Biopsy*
;
Salivary Glands*
;
Sjogren's Syndrome*
5.The midfacial degloving approach to the nose and paranasal sinuses.
Hyeon Jo KIM ; Jong Il CHOI ; Kyung Rae KIM ; Hyung Seok LEE
Korean Journal of Otolaryngology - Head and Neck Surgery 1992;35(1):75-79
No abstract available.
Nose*
;
Paranasal Sinuses*
6.Retrograde Tracheal Intubation.
Youn Woo LEE ; Young Seok LEE ; Jong Rae KIM
Yonsei Medical Journal 1987;28(3):228-230
Endotracheal intubation is especially necessary for ventilatory care in Positive End Expiratory Pressure (PEEP) therapy. In many circumstances it is difficult to obtain an adequate view of the vocal cords, and thus various technics have been used for airway management. Retrograde tracheal intubation was performed on a 73-year old male patient suffering from postoperative noncardiogenic pulmonary edema who needed ventilatory PEEP therapy. This procedure was successful and a tracheostomy was not needed. Following improvement he was discharged with out complication.
Aged
;
Human
;
Intubation, Intratracheal/methods*
;
Male
7.A clinical survey of tongue cancer.
Seung Hwan LEE ; Kyung Rae KIM ; Chyl Won PARK ; Hyung Seok LEE ; Sun Kon KIM ; Jeung Yop HAN
Korean Journal of Otolaryngology - Head and Neck Surgery 1993;36(6):1299-1306
No abstract available.
Tongue Neoplasms*
;
Tongue*
8.The Effects of Divided Doses of Neostigmine on Reversal of Vecuronium Block.
Young Seok LEE ; Jin Su KIM ; Jong Rae KIM
Korean Journal of Anesthesiology 1990;23(1):47-50
The hypothesis that administration of neostigmine in divided doses might accelerate the antagonism of nuromuscular blockade was investigated. Neostigmine 0.05mg/kg was adminsitered either in a single bolus dose (Group I, n=10) or in an initial dose of 0.01 mg/kg 1 minute later (Group II, n=10), 2 minutes later (Group III, n=10) and 3 minutes later (Group IV, n=10) for antagonism of vecuronium- induced blockade. Reversal was attepted at 10 percent spontaneous recovery of twitch height. The mean time (+/-SE) from the first injection of the drug until the train-of-four(TOF) ratio value had reached 0. 75 was signifincantly longer in Group II and IV (594.8+/-63.9 seconds and 555.6+/-22.2 seconds respectively) than Group I and III (380.6+36.0 seconds and 357.8+/-44.2 seconds respectively). It is concluded that adminstration of neostigmine in divided doses with 0. 01 mg/kg and 0.04 mg/kg did not produce a significantly faster reversal of residual vecuronium-induced neuromuscular blockade as compared to a single bolus administration.
Neostigmine*
;
Neuromuscular Blockade
;
Vecuronium Bromide*
9.Dissecting Aneurysm of Intracranial Vertebral Artery: Report of Two Autopsy Cases.
Sang Yong LEE ; Gap Rae JO ; Joong Seok SEO
Korean Journal of Legal Medicine 2000;24(1):75-81
Two autopsied cases of dissecting aneurysms of intracranial vertebral artery are reported and the appropriate literature is reviewed to investigate the pathological characteristics and pathogenesis. The location and pathological features of the aneurysms are similar in the two cases. The aneurysms in both cases are confined to the intracranial vertebral artery and massive subarachnoid hemorrhage in basal cistern develop caused by the rupture of the arterial wall. And the aneurysms show mainly subadventitial dissection and display intimal thickening, disruption of internal elastic lamina, and degeneration of the media. Based on their pathological investigation of these two cases and a review of reported cases, the authors propose that weakness of internal elastic lamina may be responsible for initiating dissection in susceptible individuals and hypertention is one of contributing factors that result in weakness of internal elastic lamina.
Aneurysm
;
Aneurysm, Dissecting*
;
Autopsy*
;
Rupture
;
Subarachnoid Hemorrhage
;
Vertebral Artery*
10.Toll-like Receptor 1/2 Agonist Pam3CSK4 Suppresses Lipopolysaccharide-driven IgG1 Production while Enhancing IgG2a Production by B Cells
Immune Network 2018;18(1):e10-
Interaction between pathogen-associated molecular patterns and pattern recognition receptors triggers innate and adaptive immune responses. Several studies have reported that toll-like receptors (TLRs) are involved in B cell proliferation, differentiation, and Ig class switch recombination (CSR). However, roles of TLRs in B cell activation and differentiation are not completely understood. In this study, we investigated the direct effect of stimulation of TLR1/2 agonist Pam3CSK4 on mouse B cell viability, proliferation, activation, Ig production, and Ig CSR in vitro. Treatment with 0.5 µg/ml of Pam3CSK4 only barely induced IgG1 production although it enhanced B cell viability. In addition, high-dosage Pam3CSK4 diminished IgG1 production in a dose-dependent manner, whereas the production of other Igs, cell viability, and proliferation increased. Pam3CSK4 additively increased TLR4 agonist lipopolysaccharide (LPS)-induced mouse B cell growth and activation. However, interestingly, Pam3CSK4 abrogated LPS-induced IgG1 production but enhanced LPS-induced IgG2a production. Further, Pam3CSK4 decreased LPS-induced germline γ1 transcripts (GLTγ1)/GLTε expression but increased GLTγ2a expression. On the other hand, Pam3CSK4 had no effect on LPS-induced plasma cell differentiation. Taken together, these results suggest that TLR1/2 agonist Pam3CSK4 acts as a potent mouse B cell mitogen in combination with TLR4 agonist LPS, but these 2 different TLR agonists play diverse roles in regulating the Ig CSR of each isotype, particularly IgG1/IgE and IgG2a.
Animals
;
B-Lymphocytes
;
Cell Proliferation
;
Cell Survival
;
Hand
;
Immunoglobulin Class Switching
;
Immunoglobulin E
;
Immunoglobulin G
;
In Vitro Techniques
;
Mice
;
Pathogen-Associated Molecular Pattern Molecules
;
Plasma Cells
;
Receptors, Pattern Recognition
;
Recombination, Genetic
;
Toll-Like Receptors