1.188Re - Labeled Radiopharmaceuticals.
Korean Journal of Nuclear Medicine 2001;35(5):293-300
No abstract available.
Radiopharmaceuticals*
2.PET Radiopharmaceuticals for Tumor Imaging.
Korean Journal of Nuclear Medicine 2002;36(1):8-18
No abstract available.
Radiopharmaceuticals*
3.PET Radiopharmaceuticals for Tumor Imaging.
Korean Journal of Nuclear Medicine 2002;36(1):8-18
No abstract available.
Radiopharmaceuticals*
4.Development of Therapeutic Radiopharmaceuticals and Their Clinical Applications.
Korean Journal of Nuclear Medicine 1997;31(3):299-309
No abstract available.
Radiopharmaceuticals*
5.Suggestions for Radiopharmaceutical Drug Development in Korea Focusing on FDA Exploratory IND Guideline.
Young Hoon RYU ; Tae Hyun CHOI
Nuclear Medicine and Molecular Imaging 2007;41(6):525-529
Regulation for the radiopharmaceuticals should be reasonably different from that of other drugs. Radiopharmaceuticals are always used by compounding based on the doctor's order, have short half life and very low administration dose. Its pharmacological effect is not from its chemical effect but from radiation. The background for exploratory IND (Investigational New Drug) explained by the FDA was to reduce the time and resources expended on candidate products that are unlikely to suceed, new tools are needed to distinguish earlier in the process those candidates that hold promise from those that do not. In this review, basic concept for exploratory IND and RDRC guideline is summarized and various suggestions for improving and expediting procedure for new radiopharmaceutical development would be described.
Half-Life
;
Korea*
;
Radiopharmaceuticals
6.Radiopharmaceuticals for Imaging of Cellular Proliferation.
Korean Journal of Nuclear Medicine 2002;36(4):209-223
No abstract available.
Cell Proliferation*
;
Radiopharmaceuticals*
7.Labelling with Rhenium-188.
Korean Journal of Nuclear Medicine 1999;33(2):193-198
There is considerable interest in 188Re due to its favorable properties as a therapeutic radionuclide. 188Re and 99mTc act as a matched pair because of their similar chemical properties, and therefore methods of labeling with 99mTc can be applied to the labeling with 188Re. With appropriately chosen agents as carriers of 188Re, the labeling can be readily carried out using 188ReO4- in the presence of a reducing agent. 188Re radio pharmaceuticals based on 99mTc complexes have been synthesized and are currently being studied for clinical use. Some of them are shown to be suitable for therapeutic use and promising for radiotherapy in nuclear medicine.
Nuclear Medicine
;
Radiopharmaceuticals
;
Radiotherapy
8.Application of automatic injection device based on automatic hemostasis in injection of radiopharmaceutical bolus injection.
Jin LI ; Wenhong FAN ; Jianxiong MA ; Wei ZHOU ; Xinxin PANG ; Cungui TIAN ; Guohui YANG ; Yan WANG ; Na ZHAO
Journal of Biomedical Engineering 2023;40(2):320-326
In clinical practice, radiopharmaceutical dynamic imaging technology requires the bolus injection method to complete injection. Due to the failure rate and radiation damage of manual injection, even experienced technicians still bear a lot of psychological burden. This study combined the advantages and disadvantages of various manual injection modes to develop the radiopharmaceutical bolus injector, and explored the application of automatic injection in the field of bolus injection from four aspects: radiation protection, occlusion response, sterility of injection process and effect of bolus injection. Compared with the current mainstream manual injection method, the bolus manufactured by the radiopharmaceutical bolus injector based on the automatic hemostasis method had a narrower full width at half maximum and better repeatability. At the same time, radiopharmaceutical bolus injector had reduced the radiation dose of the technician's palm by 98.8%, and ensured more efficient vein occlusion recognition performance and sterility of the entire injection process. The radiopharmaceutical bolus injector based on automatic hemostasis has application potential in improving the effect and repeatability of bolus injection.
Radiopharmaceuticals
;
Injections
;
Hand
9.Application of micro-bolus injection and piezoelectric sensors to improve the safety of radiopharmaceuticals bolus injection.
Jin LI ; Yan WANG ; Jianxiong MA ; Xinxin PANG ; Wei ZHOU ; Cungui TIAN ; Guohui YANG ; Na ZHAO
Journal of Biomedical Engineering 2023;40(5):982-988
Radiopharmaceutical dynamic imaging typically necessitates intravenous injection via the bolus method. However, manual bolus injection carries the risk of handling errors as well as radiological injuries. Hence, there is potential for automated injection devices to replace manual injection methods. In this study, the effect of micro-bolus pulse injection technology was compared and verified by radioactive experiments using a programmable injection pump, and the overall bubble recognition experiment and rat tail vein simulation injection verification were performed using the piezoelectric sensor preloading method. The results showed that at the same injection peak speed, the effective flushing volume of micro-bolus pulse flushing (about 83 μL/pulse) was 49.65% lower than that of uniform injection and 25.77% lower than that of manual flushing. In order to avoid the dilution effect of long pipe on the volume of liquid, the use of piezoelectric sensor for sealing preloading detection could accurately predict the bubbles of more than 100 μL in the syringe. In the simulated injection experiment of rat tail vein, when the needle was placed in different tissues by preloading 100 μL normal saline, the piezoelectric sensor fed back a large difference in pressure attenuation rate within one second, which was 2.78% in muscle, 17.28% in subcutaneous and 54.71% in vein. Micro-bolus pulse injection method and piezoelectric sensor sealing preloading method have application potential in improving the safety of radiopharmaceutical automatic bolus injection.
Animals
;
Rats
;
Radiopharmaceuticals/administration & dosage*
10.Production of 18FF2 Gas for Electrophilic Substitution Reaction.
Byung Seok MOON ; Jae Hong KIM ; Kyo Chul LEE ; Gwang Il AN ; Gi Jeong CHEON ; Kwon Soo CHUN
Nuclear Medicine and Molecular Imaging 2006;40(4):228-232
PURPOSE: Electrophilic 18F (T1/2=110 min) radionuclide in the form of [18F]F2 gas is of great significance for labeling radiopharmaceuticals for positron emission tomography (PET). However, its production in high yield and with high specific radioactivity is still a challenge to overcome several problems on targetry. The aim of the present study was to develop a method suitable for the routine production of [18F]F2 for the electrophilic substitution reaction. MATERIALS AND METHODS: The target was designed water-cooled aluminum target chamber system with a conical bore shape. Production of the elemental fluorine was carried out via the 18O(p,n)18F reaction using a two-step irradiation protocol. In the first irradiation, the target filled with highly enriched 18O2 was irradiated with protons for 18F production, which were adsorbed on the inner surface of target body. In the second irradiation, the mixed gas (1% [19F]F2/Ar) was loaded into the target chamber, following a short irradiation of proton for isotopic exchange between the carrier-fluorine and the radiofluorine absorbed in the target chamber. Optimization of production was performed as the function of irradiation time, the beam current and 18O2 loading pressure. RESULTS: Production runs was performed under the following optimum conditions: The 1st irradiation for the nuclear reaction (15.0 bar of 97 % enriched 18O2, 13.2 MeV protons, 30 micro A, 60-90 min irradiation), the recovery of enriched oxygen via cryogenic pumping; The 2nd irradiation for the recovery of absorbed radiofluorine (12.0 bar of 1% [19F]fluorine/argon gas, 13.2 MeV protons, 30 micro A, 20-30 min irradiation), the recovery of [18F]fluorine for synthesis. The yield of [18F]fluorine at EOB (end of bombardment) was achieved around 34+/-6.0 GBq (n>10). CONCLUSION: The production of 18F electrophilic agent via 18O(p,n)18F reaction was much under investigation. Especially, an aluminum gas target was very advantageous for routine production of [18F]fluorine. These results suggest the possibility to use [18F]F2 gas as a electrophilic substitution agent.
Aluminum
;
Fluorine
;
Oxygen
;
Positron-Emission Tomography
;
Protons
;
Radioactivity
;
Radiopharmaceuticals