This study was performed on 41 subjects including 10 control subjects aged 57.8+/-6.5 and 31 patients aged 62.5+/-7.4 with old myocardial infarction (OMI), using radionuclide ventriculography (RVG). In conclusion, RVG is a useful method to assess left ventricular systolic function in patients with OMI. Some parameters such as sensitivity, specificity, areas under ROC curve: EF% (93.55; 60.00; 0.912), PER (93.55; 70.00; 0.903) and 1/3ER (93.60; 80.00; 0.929) respectively are higher than those of RVG are. EF% (42.014.9), PER (2.30.7), 1/3ER (1.90.8) in patients with OMI decreased in comparing with the controls. There was a correlation between the classes of clinical heart failure and EF%, PER, 1/3ER respectively (r=-0.52; r=-0.56; r=0.38; p<0.05) in patients with OMI
Myocardial Infarction ; Radionuclide Ventriculography

38 participants of study were divided into two groups. There were 28 subjects (25 males, 3 females) in case group, who had former myocardial infarction (MI) and history of MI. The mean age of case group was 62.5+/-7.4 years. 10 healthy subjects were involved in the control group. It was found that radionuclide ventriculography is a reliable explorative method for evaluation of left ventricular function in the patients with former MI. Sensitivity, specificity and parameters of EFx% (40.3+/-14.0), PER (2.3+/-0.7), 1/3ER (1.9+/-0.8) all decreased significantly in comparison with those of the control group. Left ventricular dysfunction on ventriculography related to site of MI and clinical level of heart failure. In the patient with former MI, there was relative closed correlation between EFx%, 1/3ER and grade of heart failure and PER had modest negative correlation with grade of heart failure
Myocardial Infarction ; Radionuclide Ventriculography

35 cases of OMI (with an average of 12 months after acute MI) and 44 control subjects were studied by echo- and radionucleidoventriculography. Results shown a larger dilatation of the left ventricle of OMI patients in comparing with the controls. 81.1% of OMI patients had heart wall movement disorders and their location identified by echo was consistent with the MI location diagnosed by ECG. There is a positive proportional relation between WMSI and the severity of heart failure.
Myocardial Infarction ; Radionuclide Ventriculography

The study was conducted on 25 healthy subjects (15 males, 10 females) with age ranged from 15 - 60 years. None have heart disease that identified by physical examination, cardiogram and echocardiography. Method of R.A with SPECT and S.A.G.E - Cardiac software was used. Main measurements were emptying parameters, filling parameters and wall motion. Findings suggested that indices of EF, PFR and TPF were similar to that of other oversea studies. Indices of TES, PER, TPE, 1/3EF, 1/3ER, MFR, 1/3FF, 1/3FR were showed but could not compare with other authors because of data limitation in literature. Indices of REF and RRS of wall motion were lower than that of other studies.
Ventricular Function ; Radionuclide Ventriculography

Left ventricular(LV) diastolic filling is abnormal at rest in many patients with coronary arery disease, even in the presence of normal resting LV systolic function. To determine the effects of improved myocardial perfusion on impaired LV diastolic filling and to detect the most sensitive parameter to assess LV diastolic function, gated radionuclide ventriculography were performed in 14 patients with coronary artery disease before and after successful percutaneous transluminal coronary angioplasty(PTCA). All patients had no previous myocardial infarction and no abnormal wall motion in gated radionuclide and contrast ventriculography. The following results were obtained; 1) There were no significant differences in the parameters of LV systolic function, such as peak ejection rate(PER, time to peak ejection rate(TPER), ejection fraction(EF) after successful PTCA. 2) Peak filling rate(PFR) and time to peak filling rate(TPFR), indexes of LV diastolic function, had no significant changes after successful PTCA. 3) The percent contribution of late diastolic filling to stroke volume(%LDF/SV) decreased from 26.5+/-6.8% to 19.1+/-6.6%(p<0.005 by paired t-test). These data suggest that in many patients with angina and normal LV systolic function, impaired global diastolic filling is a reversible manifestation of impaired coronary flow, and percent contribution of late diastolic filling to stroke volume(%LDF/SV) can be a sensitive parameter to evaluate impaired LV diastolic filling in coronary artery disease.
Angina Pectoris* ; Angioplasty, Balloon, Coronary* ; Coronary Artery Disease ; Gated Blood-Pool Imaging ; Humans ; Myocardial Infarction ; Perfusion ; Radionuclide Ventriculography ; Stroke

No abstract available.
Humans ; Mitral Valve Stenosis* ; Radionuclide Ventriculography*

Ventricular performance was evaluated in 21 patients with uncomplicated acute transmural myocardial infarction (10 anterior and 11 inferior). Left ventricular global and regional ejection fraction, ejection rate and right ventricular ejection fraction were assessed using radionuclide ventriculography. The results were as follows : 1) In anterior infarction, left ventricular global ejection fraction was more significantly depressed than in inferior infarction(mean+/-SD : 33. 0+/-15.4% versus 48.6+/-7.0%, P<0.01). 2) In inferior infarction, right ventricular global ejection fraction was more depressed than in anterior infarction(33.3+/-9.8% versus 45.0+/-13.2%, P<0.05). 3) Regional ejection fraction of septal, apico-inferior and posterolateral wall were found to be depressed in anterior infarction than in inferior infarction, but no significant differences were present. It is concluded that the magnitude of right and left vnetricular dysfunction was affected by the location of acute transmural infarction.
Humans ; Infarction ; Myocardial Infarction* ; Radionuclide Ventriculography ; Stroke Volume

It has been known that dilated cardiomyopathy(DCM) is characterized by systolic dysfunction of left ventricle(LV), but there were few studies about correlation between LV systolic function, diameter and diastolic function measured by echocardiography and radionuclide ventriculography(RVG) The purpose of this study is to evaluate LV systolic and diastolic function as well as RV function using regional ejection fraction and functional images by RVG in 17 patients with DCM and to compare these variables with echocardiographic data. The results are as follows : 1) DCM showed diffuse systolic and diastolic dysfunction of LV. The systolic impairment is accounted for the diastolic impairment in DCM. 2) The increased standard deviation of phase angle of left ventricle(LVSDph) revealed LV asynchronous contraction in DCM. 3) LVSDph showed significant correlations with other RVG parameters such as LV ejection fraction, and peak ejection rate, peak filling rate and also with LV systolic and diastolic diameter measured by echocardiography. It is concluded that LVSDph may be useful in evaluation of LV systolic and diastolic function in patients with DCM as well as LV asynchronous contraction.
Cardiomyopathy, Dilated* ; Echocardiography* ; Humans ; Radionuclide Ventriculography* ; Ventricular Function, Right*

To evaluate left ventricular diastolic function in patients with coronary artery disease, gate radionuclide ventriculography was performed prospectively in 42 patients who were admitted to Seoul National University Hospital from November 1985 to August 1986 because of anterior chest pain. All patients had no valvular heart disease, congenital heart disease, cardiomyopathy and arrhythmia, and no abnormal vall motion in gated nuclide ventriculography and contrast left ventriculography. 25 patients with more than 50% of stenosis in coronary arteriography were compared with 17 control subjects without stenosis. The following results were obtained; 1) There were no significant differences between normal controls and patients with coronary artery disease in the analysis of the parameters of the left ventricular systolic function, such as ejection fraction (EF), peak ejection rate (PER), time to peak ejection rate (TPER) and ejection time (TES, TES/BCL). 2) Same results were found with those of the left vnetricular diastolic function, such as peak filling rate (PFR), diastolic time interval (DTI, DTI/BCL), rapid diastolic filling interval and time to late diastolic filling (TLDF). 3) The percent contribution of late diastolic filling to stroke volume (%LDF/SV) was more increased in patients with coronary artery disease than the normal control subjects (38.2+/-12.4% vs 28.3+/-7.8%, P<0.01). 4) As the results of above, it can be concluded that the percent contribution of late diastolic filling to stroke volume (%LDF/SV) obtained by using the non-invasive method of gated radionuclide ventriculography can be a sensitive parameter for early evaluation of the left ventricular diastolic dysfunction in coronary artery disease.
Angiography ; Arrhythmias, Cardiac ; Cardiomyopathies ; Chest Pain ; Constriction, Pathologic ; Coronary Artery Disease* ; Coronary Vessels* ; Gated Blood-Pool Imaging ; Heart Defects, Congenital ; Heart Valve Diseases ; Humans ; Prospective Studies ; Radionuclide Ventriculography ; Seoul ; Stroke Volume

To determine whether are significant diastolic left ventricular dysfunctions in mild to moderate hypertensive patients with normal systolic function, radionuclide ventriculography by in vivo red cell labelling technique using 20 mCi of (99m)Tc pertechnetate was performed in 24 hypertensive patients(mean age: 50.6+/-12.4, mean blood pressure: 156.9+/-11.8/100.6+/-7.1 mmHg) and in 11 normal subjects (mean age: 42.7+/-13.5, mean blood pressure: 123.2+/-6.8/82.3+/-3.9 mmHg). The results were as follows: 1) Ejection fraction was similar in both hypertensive and control groups (0.70+/-0.06 versus 0.70+/-0.08). 2) Mean of the peak filling rate (PFR) was significantly lower in hypertensive group (2.07+/-0.45 EDV/sec) than in control group (2.42+/-0.30 EDV/sec) (p<0.05). 3) Mean of the time to peak diastolic filling (TPDF) in hypertensive patients was 189.0+/-30.4 msec and which was significantly longer than that of control subjects (164.5+/-22.4 msec)(p<0.02). 4) Mean of the first third filling fraction (1/3 FF) in hypertensive patients was 0.22+/-0.07 and which was significantly lower than that of control subjects (0.32+/-0.09)(p<0.01). 5) Decreased PFR and delayed TPDF were also demonstrated with advances in age in both groups. Above results suggest that the diastolic evaluation of left ventricle might be necessary in the hypertensive patients with normal systolic function, and that diastolic dysfunction may precede the systolic dysfunction and clinical deterioration.
Blood Pressure ; Heart Ventricles ; Humans ; Hypertension* ; Radionuclide Ventriculography* ; Sodium Pertechnetate Tc 99m ; Ventricular Dysfunction, Left