No abstract available.
Brain ; Radiation Injuries

Biomedical Research ; Humans ; Mouth ; radiation effects ; Radiation Injuries ; therapy

No abstract available.
Humans ; Radiation Injuries/etiology ; Radiation, Ionizing ; Radiotherapy Dosage ; *Societies, Scientific

Irradiation injuries anti-agents refer to drugs that can inhibit the initial stage of radiation injuries, or reduce the development of radiation injuries and promote the recovery of injuries when used early after irradiation exposure. According to the mechanism of action and the time of intervention, the irradiation injuries anti-agents are divided into four categories: radioprotectors, radiomitigators, radiation therapeutics for external radiation exposure, and anti-agents for internalized radionuclides. In this paper, the research progress of irradiation injuries anti-agents in recent years is reviewed.
Humans ; Radiation-Protective Agents/therapeutic use* ; Radiation Injuries/prevention & control*

Central Nervous System ; radiation effects ; Eye ; radiation effects ; Humans ; Immune System ; radiation effects ; Radiation ; Radiation Injuries ; prevention & control ; Radiation Protection ; methods ; Reproduction ; radiation effects

Ear Diseases ; etiology ; Humans ; Radiation Injuries

Injury is generally defined as morphological changes due to physical or chemical stress, inflammatory or repair process, or secondary events of the other disease. In the nontraumatic injuries of the lung, direct physical effects to the lung such as contusion or rupture of the lung must be excluded. So, the types of nontraumatic injuries of lung are all pathologic changes of lung except for congenital anomalies; infectious of inflammatory disease, aspiration induced injuries, environmental or occupational lung disease, postoperative pulmonary changes, poison or drug induced toxic injuries, radiation injury, etc...
Contusions ; Lung Diseases ; Lung* ; Radiation Injuries ; Rupture

To evaluate the influence of prior that treatment on the thermal enhancement of irradiation effect after hyperthermia, an experimental study was carried out using a total of 80 mice. Hyperthermia was carried out at 43 degrees C for 40 minutes and was repeated with various intervals. A single dose of 3,000 rad was delivered on skin of mouse tail innediately after the second hyperthermia. The Skin Changes of the irradiated mouse tail were observed from 7th to 35th post-irradiation days, and the skin scores were analyzed. The Results are as follows; 1. The radiation damage on mouse skin increased significantly when radiation was combined with hyperthermia. 2. The radiation damage after repeated hyperthermia is significantly less than that after single hyperthermia, when the interval is 1 to 6 days. 3. As a result, thermal tolerance persists from 1 throungh 6 days after the initial hyperthermia.
Animals ; Fever* ; Mice ; Radiation Injuries* ; Skin ; Tail

OBJECTIVE: To confirm the therapeutic effect of recombinant human thrombopoietin (rhTPO) on rhesus monkeys irradiated with 5.0 Gy ⁶⁰Co γ-ray, and provide experimental basis for clinical treatment of similar patients. METHODS: Fourteen adult rhesus monkeys were irradiated with ⁶⁰Co γ-ray on both sides at the dose of 5.0 Gy (dose rate 69.2 cGy/min) to establish the acute radiation sickness model. The monkeys were divided into irradiation group (n=5), rhTPO 5 μg/kg group (n=4) and rhTPO 10 μg/kg group (n=5). Two hours after irradiation, the three groups of monkeys were injected with saline 0.1 ml/kg, rhTPO 5 μg/kg（0.1 ml/kg） and rhTPO 10 μg/kg(0.2 ml/kg), respectively. The general signs, survival, peripheral hemogram and serum biochemistry of rhesus monkeys were observed before and after irradiation, and the differences between rhTPO group and irradiation control group were compared. RESULTS: After total body irradiation with 5.0 Gy⁶⁰Co γ-ray, rhesus monkeys successively showed fever, hemorrhage, sharp decrease of whole blood cell counts in peripheral blood and disorder of serum biochemical indexes. Compared with the irradiated control group, a single intramuscular injection of rhTPO 5 μg/kg or 10 μg/kg 2 hours after irradiation could improve the symptoms of fever and bleeding, increase the nadir of peripheral red blood cells and platelets counts, shorten the duration of hemocytopenia, and advance the time for blood cells to return to the pre-irradiation level. The serum biochemical results showed that rhTPO could improve the abnormality of serum biochemical indexes in rhesus monkeys induced by 5.0 Gy total body irradiation to some extent. Compared with the two administration groups, the therapeutic effect of rhTPO 10 μg/ kg was better. CONCLUSION A single injection of rhTPO 5 μg/ kg or 10 μg/ kg 2 hours after irradiation can alleviate the injury of multilineage hematopoiesis and promote the recovery in monkeys irradiated by 5.0 Gy γ-ray. It also improves animal signs and has obvious therapeutic effect on acute radiation sickness.
Humans ; Animals ; Macaca mulatta ; Radiation Injuries

Radiation exposure during fluoroscopy has been of consistent interest because fluoroscopy is used not only for diagnostic purposes such as upper gastrointestinal series but for many minimally-invasive treatments in various clinical fields. In 2000, the International Commission on Radiological Protection published the important report about the avoidance of radiation injuries from medical interventional procedures, and this report defined harm during fluoroscopic-guided interventional procedure and how to reduce the radiation dose of patients and staff. Two aspects of fluoroscopy exposure differ from other types of medical radiation exposure, including computed tomography. One is that the entrance surface dose during an interventional procedure may be very high, so the deterministic effects of radiation such as skin or corneal injury should be emphasized more than stochastic effects such as cancer risk. The other is that the variation in radiation exposure is great for the same kind of procedure, so it is very difficult to generate a reference level for the radiation dose. Therefore, it is necessary to develop a guideline for the use of fluoroscopy through a nationwide survey about irradiation during fluoroscopic examinations and fluoroscopy-guided intervention procedures. In conclusion, radiation exposure by fluoroscopic guided intervention is not negligible, and the practitioner should always aim to reduce radiation exposure during interventional procedures.
Fluoroscopy ; Humans ; Radiation Dosage ; Radiation Injuries ; Radiation Monitoring ; Radiography, Interventional ; Radiology, Interventional ; Skin