1.Tc‑99 m Ubiquicidin Imaging in Orbital Aspergilloma: an Illustration
Meivel ANGAMUTHU ; Nishikant DAMLE ; Dikhra KHAN ; Rachna MEEL ; Sanjay SHARMA ; Chandrasekhar BAL
Korean Journal of Nuclear Medicine 2023;57(3):162-163
Aspergillus infection is relatively rare disease, and we present a case of orbital aspergillus infection who presented with right orbital pain and swelling. Right orbital lesion was identified on CT, MRI, and PET-CT imaging followed by confirmation of aspergillus on histopathological examination. We demonstrate that Tc-99 m ubiquicidin scan can yield positive results in aspergillosis too, enabling its differentiation from non-infective pathologies.
2.Orbital IgG4 Disease: Imaging Findings on 68Ga-DOTANOC PET/CT
Saurabh ARORA ; Nishikant A DAMLE ; Rachna MEEL ; Sanjay SHARMA ; Seema SEN ; Chandrasekar BAL ; Kanak LATA ; Sneha PRAKASH ; Divya YADAV ; Meivel ANGAMUTHU
Korean Journal of Nuclear Medicine 2019;53(6):432-435
Immunoglobulin G4 (IgG4)–related diseases are a spectrum of systemic inflammatory conditions of unknown etiology, which are characterized by infiltration of tissues by IgG4 plasma cells and sclerosing inflammation (Cheuk and Chan Adv Anat Pathol 17:303-32, 2010). Although this condition was initially described in relation to autoimmune pancreatitis, now it has been reported in almost every organ system of body (Zen and Nakanuma Am J Surg Pathol 34:1812-9, 2010, Masaki et al. Ann Rheuma Dis 68:1310-5, 2009). Orbital involvement by IgG4 disease can involve extraocular muscles (EOM), lacrimal glands, conjunctiva, eyelids, infraorbital nerve, orbital fat, and nasolacrimal system (McNab and McKelvie. Ophthal Plast Reconstr Surg 31:167-78, 2015, Katsura et al. Neuroradiology 54:873-82, 2012). The basis of using â¶â¸Ga-DOTANOC PET/CT in IgG4 orbital disease is the known expression of somatostatin receptors in chronic inflammatory cells (Cuccurullo et al. Indian J Radiol Imaging 27:509-16, 2017) and also avidity shown previously in other IgG4-related diseases (Cheng et al. Clin Nucl Med 43:773-6, 2018).
3.Orbital IgG4 Disease: Imaging Findings on 68Ga-DOTANOC PET/CT
Saurabh ARORA ; Nishikant A DAMLE ; Rachna MEEL ; Sanjay SHARMA ; Seema SEN ; Chandrasekar BAL ; Kanak LATA ; Sneha PRAKASH ; Divya YADAV ; Meivel ANGAMUTHU
Korean Journal of Nuclear Medicine 2019;53(6):432-435
Immunoglobulin G4 (IgG4)–related diseases are a spectrum of systemic inflammatory conditions of unknown etiology, which are characterized by infiltration of tissues by IgG4 plasma cells and sclerosing inflammation (Cheuk and Chan Adv Anat Pathol 17:303-32, 2010). Although this condition was initially described in relation to autoimmune pancreatitis, now it has been reported in almost every organ system of body (Zen and Nakanuma Am J Surg Pathol 34:1812-9, 2010, Masaki et al. Ann Rheuma Dis 68:1310-5, 2009). Orbital involvement by IgG4 disease can involve extraocular muscles (EOM), lacrimal glands, conjunctiva, eyelids, infraorbital nerve, orbital fat, and nasolacrimal system (McNab and McKelvie. Ophthal Plast Reconstr Surg 31:167-78, 2015, Katsura et al. Neuroradiology 54:873-82, 2012). The basis of using ⁶⁸Ga-DOTANOC PET/CT in IgG4 orbital disease is the known expression of somatostatin receptors in chronic inflammatory cells (Cuccurullo et al. Indian J Radiol Imaging 27:509-16, 2017) and also avidity shown previously in other IgG4-related diseases (Cheng et al. Clin Nucl Med 43:773-6, 2018).
Conjunctiva
;
Eyelids
;
Immunoglobulin G
;
Immunoglobulins
;
Inflammation
;
Lacrimal Apparatus
;
Muscles
;
Orbit
;
Orbital Diseases
;
Pancreatitis
;
Plasma Cells
;
Positron-Emission Tomography and Computed Tomography
;
Receptors, Somatostatin