80% subjects among 50 bitten by dogs/cats were fully injected 4-6 doses of rabies vaccine. By ELISA (platelia Rage kit of Diagnostic Pasteur), we found that 42.5% of serum samples taken after injection 4 doses of rabies vaccine have titer 0.5IU/ml, it met WHO's minimum requirement. The GMT was 2.71 EU/ml. 62.5% of serum samples taken after injection 6 doses of rabies vaccine have titer 0.5IU/ml. The GMT was 3.14UE/ml.
Vaccines ; Rabies

This is a study on establishing the National References for inactivated rabies vaccine for human produced in ViÖt Nam. The results showed that the ViÖt Nam National References for Rabies Vaccine met the requirements of WHO
Vaccines ; Rabies

Standard lyophylized rabid vaccine produced from CVS strain of Biopharma-Indonesia has met the criterion in terms of sterility, safety, efficacy (14.24 IU/ml), thermo-stability 37oC/month (5.4 IU/ml) and residual humidity (3.34%). Immune responsivity of the standard sample vaccine was determined by neutralizing method reaching 1/5 = 3.8 IU/ml; 1/25 = 1.7 IU/ml and 1/125 = 0.7 IU/ml
Rabies Vaccines ; Vaccines ; immunization

A purified rabie vaccine was prepared from mouse brain of CVS/P II from the Institute Bipharma-Indonesia. After refrigerating centrifuged, the vaccine was more pure and more efficacy. The sterility, innocuity and potency were perfect
Rabies Vaccines ; Vaccines ; immunization

21,933 people were bitten by mad suspected cattles had been vaccinated and 171 patients died due to rabies during 1990-1997 in Hai Phong city. The mortality rate due to no vaccination was 76%, inadequate vaccination 12,9%. There wasn't death following the results of 100 cases who had been selected for study to evaluate the effect of Fuenzalida vaccine
vaccines ; Rabies ; death

Vnukovo-32 a cell culture rabies is used to study the vaccine strain technology of inactivated culture rabies vaccine production in primary hamster kidney cells. The master and working seeds meet the criteria of rabies vaccine strain titer (5.5 log LD 50 - 7.1 log LD 50/ml) according to WHO standard. During the study, we have used the procedure for inactivated, non concentrated rabies vaccine production of Russia and other countries procedures as references. The result was we constructed the procedure for inactivated, concentrated cell culture rabies vaccine production at laboratory scale.
Rabies Vaccines ; Cells, Laboratories

Vnukovo-32 (cell culture rabies virus vaccine strain) was propagated experimentally in primary hamster kidney cell (PHKC), primary Chick embryo fibroblast cell (CEF) and human diploid cell (WI-38). These 3 cell lines were infected with Vnukovo-32 by the same mount of infection (MOl) - lLD50/l000 cells. The result showed that the Vnukovo-32 was adapted on all experimental cell lines, met the criteria of master seed (the titer ranging 6.4-7.5 log LD50/ml), and reached the highest titer on the 7th - 9th day postinfection in three cell groups. Moreover, the highest titer of Vnukovo-32 was met in human diploid cell (WI-38), then in PHCK, and the lowest was in CEF. From these results, it is suitable to use WI-38 to propagate Vnukovo-32 for master and working seed. The procedure for propagation of Vnukovo-32 is set up.
Rabies Vaccines ; Cells

An effective strategy for preventing rabies consists of controlling rabies in the host reservoir with vaccination. Rabies vaccine has proven to be the most effective weapon for coping with this fatal viral zoonotic disease of warm-blooded animals, including human. Natural rabies infection of an individual is always associated with exposure to rabid animals, and the duration of clinical signs can vary from days to months. The incubation period for the disease depends on the site of the bite, severity of injury, and the amount of infecting virus at the time of exposure. The mortality of untreated cases in humans is 100%. Over the last 100 years, various rabies vaccines have been developed and used to prevent or control rabies in animals, such as modified live vaccine, inactivated rabies vaccine, and oral modified live vaccine. These have proved safe and efficacious worldwide. New-generation rabies vaccines, including recombinant rabies virus-based vaccines, vectored vaccines, DNA-based vaccines, and plant vaccines, have been explored to overcome the limitations of conventional rabies vaccines. This article discusses current and next-generation rabies vaccines in animals.
Animals ; Bites and Stings ; Plants ; Rabies ; Rabies Vaccines ; Vaccination ; Vaccines ; Viruses

40 out of 50 subjects bitten by dog/cat were injected completely 4- 6 doses of rabies vaccine. Using ELISA, the authors found that 42.5% of serum samples that taken after injecting 4 doses of rabies vaccine had antibody titer 0.5IU/ml, met the WHO’s minimum requirement. The GMT was 2.71IU/ml. 62.5% of serum samples taken after injecting 6 doses of rabies vaccine had antibody titer 0.5IU/ml. The GMT was 3.14EU/ml
Immune System ; Vaccines ; Rabies ; Autoimmunity

40 out of 50 subjects bitten by dog/cat were injected completely 4- 6 doses of rabies vaccine. Using ELISA, the authors found that 42.5% of serum samples that taken after injecting 4 doses of rabies vaccine had antibody titer ³0.5IU/ml, met the WHO’s minimum requirement. The GMT was 2.71IU/ml. 62.5% of serum samples taken after injecting 6 doses of rabies vaccine had antibody titer ³0.5IU/ml. The GMT was 3.14EU/ml.
Immune System ; Vaccines ; Rabies ; Autoimmunity