PURPOSE: The purpose of this study was to verify the effectiveness of the model based on the TPB, behavior-related theories, and exercise-related empirical studies in predicting exercise intention and behavior. METHODS: The subjects who participated in this study were 152 middle-aged women. The data were analyzed by use of SAS PC program and LISREL 8.12a program. RESULTS: 1) The overall fit of the hypothetical model to the data was acceptable(x2 24.01(p=0.0043), x2/df 2.67, RMSEA 0.11, standardized RMR 0.04, GFI 0.97, AGFI 0.84, NFI 0.95, NNFI 0.85). 2) Affect, subjective norm, perceived behavioral control and habit were significant determinants of the exercise intention. Attitude and facilitating conditions were not significant determinants. These six variables explained 43% of the total variance of the exercise intention. 3) Perceived behavioral control and habit were significant determinants of the exercise behavior. Intention and facilitating conditions were not significant determinants. These four variables explained 95% of the total variance of the exercise behavior. CONCLUSION: This study shows the model's applicabiltiy in explaining exercise behavior of middle-aged women, and suggests that we should focus on perceived behavioral control and habit rather than intention to improve exercise behavior of middle-aged women.
Female ; Humans ; Intention

This study has been undertaken in order to 1) test the effect of health education on the performance of health promoting lifestyle, self efficacy, control and perceived health status in college students, 2) assess whether pretreatment level of self-efficacy, control, and perceived health status predict post-treatment health promoting lifestyle, 3) assess whether pre-to post-treatment changes in self-efficacy, control, and perceived health status predict post-treatment health promoting lifestyle, and 4) examine the correlation between changes in subscales of health promoting lifestyle. One-group pretest-posttest design was used. Fifty eight college students at T college in T city were studied. They attended a health education, which is composed of 13 sessions(one session per week, 130 minutes per one session). This study was conducted from August 26 to December 2. The instrument used for this study included a survey of general characteristics, self-efficacy, control, perceived health status and health promoting behavior. Analysis of data was done by use of mean, percentage, paired t-test, pearson correlation coefficient and stepwise regression. The results of this study are summarized as follows : 1) The average item score for the health promoting lifestyle was low at 2.301. In the sub-categories, the highest degree of performance was interpersonal support(2.87), following self actualization, nutrition, stress management, exercise, and the lowest degree was health responsibility(1.67). Female students had lowest degree in exercise subscale(1.48). A significant correlation between self-efficacy and control, self-efficacy and perceived health status, self-efficacy and health promoting lifestyle, control and health promoting lifestyle. Self-efficacy was the highest factor predicting health promoting lifestyle of college students(38.31%). 2) No significant difference among total health promoting lifestyle and subcategories of health promoting lifestyle. Self-efficacy was increased after health education than that of before education(T=2.33, P=.023). Control was decreased after education than that of before education(T=-2.03, P=.046). 3) Pretreatment self-efficacy, control, and health status did not predict post-treatment health promoting lifestyle. 4) Pre-to post-treatment changes in self-efficacy predicted post-treatment stress management subscore. 5) Pre-to post-treatment changes in control predicted post-treatment self actualization and exercise subscale. A significant correlation between changes in self-actualization and changes in exercise, changes in self-actualization and changes in nutrition, changes in health responsibility and changes in exercise, changes in exercise and changes in interpersonal support, changes in exercise and changes in stress management, changes in nutrition and changes in interpersonal support, and changes in interpersonal support and changes in stress management.
Education ; Female ; Health Education* ; Humans ; Life Style* ; Self Efficacy

This study was undertaken in order to examine the effect of hardiness on future stress-related physical symptoms in the female students in a longitudinal design. The subjects who participated in this study were 97 female nursing students (in the analysis of data after 1 year). The instruments used for this study were a survey of general characteristics, stress (43 items), hardiness(25 items), and physical symptoms(35 items). Analysis of data was done by use of mean and hierarchical multiple regression with the SAS program. The results of this study were as follows. 1) Main effects of hardiness on future stress-related physical symptoms was found. 2) The stress buffering effects of hardiness were not found.
Female ; Humans ; Longitudinal Studies* ; Nursing* ; Students, Nursing*

Hydrocephalus is a common malformation of the central nervous system and its cause may be either congenital or acquired. The imbalance between CSF formation and absorption, obstruction of CSF pathways, impaired venous absorption, and over secretion of CSF results in excessive accumulation of the fluid in the ventricles, leading to hydrocephalus. Although ventriculo-peritoneal shunt is regarded as the main and definitive therapy for rapidly progressive hydrocephalus, shunts in newborns have a high failure rate and thus there have been a search for alternative non-invasive techniques. Acetazolamide is a carbonic anhy- drase inhibitor, which acts by reducing production of CSF in the choroid plexus. Admini- stration of acetazolamide will decrease the rate of CSF production, preventing progressive ventricular enlargement. We experienced three cases of neonatal hydrocephalus successfully treated by long-term administration of acetazolamide. Brief review and related literatures were also presented.
Absorption ; Acetazolamide* ; Carbon ; Central Nervous System ; Choroid Plexus ; Humans ; Hydrocephalus* ; Infant, Newborn ; Ventriculoperitoneal Shunt

PURPOSE: To examine the expression of Connective Tissue Growth Factor (CTGF) in osteosarcoma and to evaluate its role in osteosarcoma invasion and proliferation. MATERIALS AND METHODS: The mRNA expression of CTGF from 23 patient-derived osteosarcoma cell lines was examined, and the role of CTGF in cell invasion and proliferation was examined using siRNA transfection. RESULTS: The over-expression of CTGF mRNA was observed in 17 cell lines (74%). CTGF-specific siRNA transfection into SaOS-2 and MG63 cell lines resulted in efficient knockdown of CTGF expression on Western blot analysis. siRNA transfected cells showed decreased migration on Matrigel invasion assay and decreased cell proliferation on WST-1 assay. CONCLUSION: These results indicated that the CTGF expression may play an important role in osteosarcoma progression, and may be a therapeutic target of osteosarcoma.
Blotting, Western ; Cell Line ; Cell Proliferation ; Connective Tissue Growth Factor ; Osteosarcoma* ; RNA, Messenger ; RNA, Small Interfering ; Transfection

No abstract available.
Mass Screening*

The present study was aimed at investigating the effect of cyclosporine A (CsA) on the renal renin-angiotensin systems. In rats chronically treated with CsA, the intrarenal expression of various genes of the renin-angiotensin system was assessed by Northern blot analysis. Along with the increases in plasma and renal renin activities, chronic CsA-treatment differentially affected the renal expression of renin-angiotensin system. The treatment with CsA for one week did not significantly alter the expression of either type 1 angiotensin II receptor (AT1A) or angiotensinogen gene, but increased the renin mRNA level. The three-week-treatment caused increases in the expression not only of renin but also of AT1A and angiotensinogen genes. Supplementation with L-arginine kept the expression of renin mRNA normal in the one-week-treated, but failed to prevent the alterations of the gene expression in the three-week-treated. Feedback control among components of the renin-angiotensin system also influences angiotesinogen. In the liver, the expression of angiotensinogen mRNA was decreased by the CsA-treatment for either one- or three-weeks. In conclusion, chronic CsA-treatment is associated with a differential expression of various genes for the renin-angiotensin system. L-Arginine may be effective in maintaining the normality of renin-angiotensin system only during early period after beginning the use of CsA.
Angiotensinogen ; Animals ; Arginine ; Blotting, Northern ; Cyclosporine* ; Gene Expression ; Liver ; Plasma ; Rats ; Receptors, Angiotensin ; Renin ; Renin-Angiotensin System* ; RNA, Messenger

PURPOSE: This study was done to develop the concept of grief focusing on the process of spousal bereavement in Korea. METHODS: The Hybrid model was used for analysis according to the 3 phases. An extensive literature review was done for the Theoretical phase. In-depth interviews were conducted with 15 participants whose spouses died within the past 3 years in the Field phase. In the Final analytic phase, the results in the Theoretical and the Field phases were compared, analyzed, and integrated according to the process of grief. RESULTS: The antecedent of the concept of spousal grief was spousal death. The dimensions of grief were classified to inner dimensions related to oneself, relational dimensions related to family and others, and existential dimensions related to the meaning of being. The attributes of grief were physical suffering, decline of cognitive ability, heartbreaking sorrow, expectations and conflicts of a new life, social stigma, dependence on or resentment towards God, etc. The empirical referent of grief was physical, psychological, social, and spiritual health status. The grieving progressed through 3 phasesshock-emancipation, suffering, and integration. CONCLUSION: Nurses should recognize the importance of their unique position as supporters for grievers, and try to assess individual characteristics and to provide tailored nursing interventions.
Adaptation, Psychological ; Attitude to Death ; Attitude to Health ; *Bereavement ; *Concept Formation ; Family/psychology ; Female ; *Grief ; Health Status ; Humans ; Interviews as Topic ; Life Change Events ; Male ; Nursing Methodology Research ; Social Support ; Spouses/*psychology ; Widowhood/*psychology

Bullous pemphigoid(BP) and herpes gestationis(HG) are subepidermal bullous diseases which show clinical and immunological similarities. Both diseases show immune deposits along the basement membrane zone and their autoantibodies bind a common antigenic site within the non-collagenous stretch of the 180 kDa BPAG2 ectodomain. Besides its association with pregnancy, HG has some characteristic features that distinguish it from BP. The serum of patients with HG often contains an IgG that avidly fixes complement, and showes IgG1 subclass predominance. We report here two cases of non-pregnant young women presenting clinical and histological features of bullous pemphigoid or herpes gestationis. The immunopathology, IgG subtyping and immunoblotting studies showed that the autoantibodies in the patients were the characteristic ones of herpes gestationis. The patients might be a subtype of BP that have characteristics of autoantibodies of HG patients.
Autoantibodies* ; Basement Membrane ; Complement System Proteins ; Female ; Humans ; Immunoblotting ; Immunoglobulin G ; Pemphigoid Gestationis* ; Pemphigoid, Bullous* ; Pregnancy

PURPOSE: The purpose of this study was identify the influences of occupational stress and burnout on turnover intention of caregivers in geriatric hospitals. METHODS: The data were collected from 176 caregivers working at three geriatric hospitals located in Gyeonggi province. A self-reported questionnaires was used to assess the level of occupational stress, burnout and turnover intention. The data were analyzed with descriptive statistics, t-test, ANOVA and Pearson correlation coefficients and multiple regression by SPSS/WIN 18.0 program. RESULTS: The turnover intention was positively correlated with occupational stress(r=.438, p<.01) and burnout(r=.418, p<.01). The influencing factors of turnover intention were occupational stress(beta=.290, p<.001), burnout(beta=.253, p=.001) and education level(beta=.182, p=.006). CONCLUSION: The results of this study indicate that it is necessary to develop stress management program so that caregivers in geriatric hospitals can reduce occupational stress and burnout.
Caregivers ; Humans ; Intention ; Surveys and Questionnaires